Homologous serum hepatitis following transfusion in an infant

RELATION OF HOMOLOGOUS SERUM HEPATITIS TO PROPHYLACTIC INJECTION OF HUMAN BLOOD FRACTIONS<subtitle>A Study of 13,755 Cases with Injections</subtitle>

“…Three of the patients whose cases were reported by Bruyn,26 Wood and Black 2T and Moloshok 23 (case 4) had been treated for hemolytic anemia of the newborn and icterus gravis. Liver damage is known to be an integral part of this condition,28 and Rosenblatt29 reported three cases of massive necrosis of the liver in infants with erythroblastosis fetalis after exchange transfusions.…”

Neonatal Hepatitis and Its Relation to Viral Hepatitis of Mother

“…X-rays of chest were normal. Liver function tests showed : Total protein, 6 Two weeks after the patient's admission the biliary passages were explored, and a wedge biopsy specimen of the liver was taken. The biliary pass¬ ages were normal, the gallbladder was filled with thin bile, but the liver was enlarged and finely granular.…”

“…There are now several instances reported in the literature where liver damage, including giantcell hepatitis, has been seen in the offspring of mothers suffering from viral hepatitis during preg¬ nancy. 6. In several instances of giant-cell hepatitis of the newborn the mother of the affected infants was known to have suffered at one time from an attack of viral hepatitis.…”

Homologous Serum Jaundice in Infancy

“…We have been able to discover only one possible case in the literature (Scheinberg et al, 1947), though another more fully substantiated case, following not plasma but blood transfusion in an infant, has recently been described (Bruyn, 1947). In later childhood, however, jaundice has followed the use of convalescent serum in several instances (Propert, 1938 ;Beeson et al, 1944), while in adults it is a common complication of plasma therapy (British Medical Journal, 1946, 2, 423), Dccurring in 7.3% of cases in one large series (Spurling et al, 1946).…”