Neonatal Hepatitis and Its Relation to Viral Hepatitis of Mother

Cirrhosis Associated with the Australia Antigen in an Infant Who Acquired Hepatitis from Her Mother

“…Though the infant appeared well after the attack of acute viral hepatitis, there was persistent hepatosplenomegaly with raised transaminase and bilirubin levels, indicating active hepatitis during the progression to cirrhosis associated with giant cells. Aterman (1963) reported two siblings who died with giant cell hepatitis after an attack of infective hepatitis in the mother, and strongly favoured the view that giant cell hepatitis of the newborn is a form of viral hepatitis acquired from the mother. The detection of the Au antigen in the mother and infant here described provides evidence to support this view, and since the mother has become a chronic carrier her future children will presumably be at high risk of developing neonatal hepatitis.…”

Postinfantile Giant Cell Hepatitis Due to Hepatitis E Virus Along with the Presence of Autoantibodies

“…Giant hepatocytes are not infrequently associated with neonatal and infantile liver pathologies but are rarely seen in adult liver disease [7][8][9]. The combination of hepatitis and extensive giant cell transformation in adult liver has been referred to as "postinfantile GCH" or "syncytial GCH" [2].…”

Bioassay of Thyroid Stimulating Hormone Using the Goldfish

“…Aterman (1963) reported two siblings who died with giant cell hepatitis after an attack of infective hepatitis in the mother, and strongly favoured the view that giant cell hepatitis of the newborn is a form of viral hepatitis acquired from the mother. The detection of the Au antigen in the mother and infant here described provides evidence to support this view, and since the mother has become a chronic carrier her future children will presumably be at high risk of developing neonatal hepatitis.…”