Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus

Signorello, Maria Grazia; Viviani, Giorgio Luciano; Armani, U; Cerone, R.; Minniti, G.; Piana, A; Leoncini, Giuliana

doi:10.1016/j.thromres.2006.11.008

Cited by 45 publications

(61 citation statements)

References 43 publications

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“…Several effects produced by Hcy on vascular cells have been described, such as diminished NO (nitric oxide) released from endothelial cells [11], increased ROS [12], potentiation of low-density lipoproteins oxidation [13]. Also, it was shown that Hcy decreases NO content enhancing ROS generation [14]. In addition, certain antioxidants, such as vitamin E (vit E), a fat-soluble vitamin and potent chain-breaking antioxidant helps to prevent damage to the lipids by the free oxygen radicals mediated tissue injuries in diabetes [15] and it acts as the first line of defense against lipid peroxidation, protecting the cell membranes from free radical attack [16].…”

Section: Protective Effects Of Vitamin E On Diabetes-induced Oxidativmentioning

confidence: 99%

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Beyramzadeh¹,

Ansari²,

Azimzadeh³

et al. 2017

JPP

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Abstract:Objective: We aimed to investigate protective effects of vit E on oxidative stress status and homocysteine (Hcy) in cardiac tissue of diabetic rats. Methods: Sixteen Wistar male rats were treated with STZ (streptozotocin) (60 mg/kg) to induce diabetes. Diabetic rats were divided into two groups: NTD (non-treated diabetic) and V E TD (vit E-treated diabetic) rats. The V E TD group received 300 mg/kg vit E with daily feeding. Eight normal rats of the same age were used as the control group. After 6 weeks, the rats were anesthetized, their cardiac tissue was removed, and homogenated supernatant was separated. Samples were assayed for TAC (total antioxidant capacity), LPO (lipid peroxidation), nitrite (NO 2 -), nitrate (NO 3 -), and Hcy. Key Findings: The contents of LPO, NO 3 -and Hcy in NTD compared to control group indicate a significant increase, but the levels of these parameters decreased in V E TD (p < 0.05). There was a significant decrease in the amount of TAC in the NTD group but in V E TD group, that significantly increased (p < 0.05). The amount of NO 2 -in NTD and V E TD groups, compared to the control group, did not show any significant changes (p > 0.05).Conclusions: Significant decrease of oxidative stress and Hcy in the cardiac tissue caused by vit E supplementation strongly indicated that this radical scavenger may promote a protective effect on diabetic cardiomyopathy through the attenuation of oxidative stress and increase antioxidant defense mechanism.

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Section: Protective Effects Of Vitamin E On Diabetes-induced Oxidativmentioning

confidence: 99%

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Beyramzadeh¹,

Ansari²,

Azimzadeh³

et al. 2017

JPP

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“…NO azalması endotel disfonksiyonuna, endotel kan akımında azalma ve KON'a yol açan sinir lifi iskemisi ile sonuçlanabilecek vazomotor tonus bozukluğuna sebep olabilir (9) . Hiperhomosisteinemisi olan tip 2 diyabetik hastalarda endotelden bağımsız vazodilatasyonun hiperhomosisteinemisi olmayan diyabetiklere göre daha fazla azaldığı gösterilmiştir (14) . Ancak, homosistein aracılı NO azalması sonucu gelişen sinir lifi iskemisive KON gelişimi arasında-ki nedensellik ilişkisinin yeterince aydınlatılması için çok sayı-da çalışmaya ihtiyaç vardır.…”

Section: Discussionunclassified

Association between Cardiac Autonomic Neuropathy and Homocysteine Level in Patients with Type 2 Diabetes Mellitus

Avcı¹,

Tabakçı²,

Toprak³

et al. 2016

Kosuyolu Heart Journal

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Giriş: Kardiyak otonomik nöropati (KON) diyabetik hastalarda artmış morbidite ve mortalitenin önemli bir sebebidir. Bu çalışmadaki amacımız diyabetik hastalarda plasma homosistein seviyesi ve anormal kalp hızı toparlanma indeksiyle belirlenen KON arasındaki ilişkiyi incelemektir. Hastalar ve Yöntem:Bu çalışmaya koroner arter hastalığı şüphesiyle efor testi istenen 35 diabetes mellitus (DB) hastası alındı. KON tanısı için kalp hızı toparlanma indeksinin ≤ 21 olması kabul edildi.Bulgular: Çalışmaya dahil edilen tip 2 diyabetik hastalar normal kalp hızı toparlanma indeksi olanlar (> 21, n= 19) ve anormal kalp hızı toparlanma indeksi olanlar (≤ 21, n= 16) olmak üzere 2 gruba ayrıldı. Gruplar arasında klinik değişkenler, laboratuvar verileriyle yaş, hipertansiyon, hiperlipidemi ve sigara gibi risk faktör-leri açısından farklılık yoktu. Ancak anormal kalp hızı toparlanma indeksi olan hasta grubunda homosistein seviyesi ve diyabet süresi normal kalp hızı toparlanma indeksi olan gruba göre anlamlı derecede yüksek bulundu (17.94 ± 5.91 umol/L'e karşı 13.27 ± 2.75 umol/L, p= 0.009 ve 10.06 ± 6.20'ye karşı 6.21 ± 4.87, p= 0.048, sırasıyla). Homosistein seviyesi ve anormal kalp hızı toparlanma indeksi arasındaki ilişki diğer değişkenlerden bağımsızdı [Odds oranı 1.319 (%95 CI: 1.011-1.721), p= 0.041]. Homosistein seviyesi ve kalp hızı toparlanma indeksi arasında istatistiksel olarak anlamlı negatif korelasyon izlendi (r= -0.382, p= 0.024). ≥ 15.02 umol/L homosistein değerinin anormal kalp hızı toparlanma indeksini belirlemede sensitivitesi %75, spesifi tesi ise %63.2 olarak bulundu.Sonuç: Tip 2 diyabetik hastalarda plasma homosistein seviyesi ve kalp hızı toparlanma indeksi arasında negatif korelasyon gösteren anlamlı bir ilişki mevcuttur. Diyabetik hastalarda KON'un gelişimi ve takibinde homosistein seviyesinin değerlendirilmesi yardımcı olabilir.Anahtar Kelimeler: Tip 2 diabetes mellitus; kardiyak otonomik nöropati; kalp hızı toparlanma indeksi Association between Cardiac Autonomic Neuropathy and Homocysteine Level in Patients with Type 2 Diabetes MellitusABSTRACT Introduction: Cardiac autonomic neuropathy is an important cause of increased morbidity and mortality in patients with diabetes mellitus. The aim of this study was to investigate the association between plasma homocysteine level and cardiac autonomic neuropathy assessed using the abnormal heart rate recovery index in patients with type 2 diabetes mellitus. Patients and Methods:Thirty-fi ve patients with type 2 diabetes mellitus who underwent an exercise stress test were included in the study. Abnormal heart rate recovery index was defi ned as ≤ 21 beat/min, which indicated cardiac autonomic neuropathy. Results:Patients with type 2 diabetes mellitus were divided into two groups, that is, patients with a heart rate recovery index of > 21 beat/min and those with a heart rate recovery index of ≤ 21 beat/min. Clinical variables, laboratory variables and risk factors, such as age, hypertension, hyperlipidemia and smoking, were not different between the groups. However...

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“…Several studies have identified elevated plasma HCYS as a risk factor for cardiovascular disease (CVD) [1][2]. In particular, hyperhomocysteinemia appears to stimulate oxidative stress and inhibit nitric oxide formation, which could explain the atherogenic effects described in type 2 diabetics [3]. Furthermore, the HCYS level is affected by age, and multiple studies suggest a relationship between HCYS levels and establish risk factors for CVD in elderly subjects [4][5].…”

Section: Introductionmentioning

confidence: 99%

Homocysteinemia, hypertension, and family history of diabetes in a smoking male population in Saudi Arabia

Al-Daghri

Al‐Attas

2008

Open Medicine

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AbstractArabs have a lower incidence of atherosclerosis than other ethnicities, but few studies have examined homocysteine (HCYS) as a risk factor for cardiovascular disease in this population. Here, we investigated the association between serum HYCS levels and risk factors for cardiovascular disease (smoking, hypertension, and family history of diabetes) in Saudi males. A total of 50 smokers and 72 nonsmokers completed a general health questionnaire. In addition, their lipid profiles were measured using routine methods and HCYS levels by high-performance liquid chromatograph with electrochemical detection. Regression analysis showed negative associations between HCYS and glucose (r = −0.22; P < 0.05) as well as family history of diabetes (r = −0.21; P < 0.05). HCYS levels were similar between hypertensive and nonhypertensive smokers, but they were significantly elevated in hypertensive nonsmokers (P = 0.027) and lower in smokers with family history of diabetes (P = 0.01). Levels of HCYS among nonsmokers inversely correlated with history of diabetes and elevated glucose. Nonsmokers’ HCYS levels were significantly elevated in the presence of hypertension and correlated with diastolic blood pressure. Thus, HCYS may be a predictor of hypertension among nonsmokers. Until further trials are conducted, we recommend vitamin B6/folic acid supplementation for the Saudi hypertensive population as an adjuvant therapy.

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Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus

Cited by 45 publications

References 43 publications

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Association between Cardiac Autonomic Neuropathy and Homocysteine Level in Patients with Type 2 Diabetes Mellitus

Homocysteinemia, hypertension, and family history of diabetes in a smoking male population in Saudi Arabia

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