Homocysteine in breast cyst fluid

Tallová, Jaroslava; Tomandl, Josef; Bičı́ková, Marie; Šimíčková, Marta

doi:10.1046/j.1365-2362.2001.00857.x

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Adrenal stimulation in children increased PregS parallel to cortisol levels enabling the usage of PregS in diagnosis of various adrenal and pituitary diseases in children [27,42]. A more general role of PregS became evident by reports of changed PregS levels in disease states [43,44,45,46,47]. For example, PregS serum concentrations are reduced in hypothyroidism and 7fold increase in hyperthyroidism [46].…”

Section: Pregnenolone Sulfate Levels In Serum and Tissuesmentioning

confidence: 99%

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

Harteneck

2013

Molecules

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Pregnenolone sulfate is a steroid metabolite with a plethora of actions and functions. As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes. Interestingly, as a sulfated steroid, pregnenolone sulfate is not the final-or waste-product of pregnenolone being sulfated via a phase II metabolism reaction and renally excreted, as one would presume from the pharmacology textbook knowledge. Pregnenolone sulfate is also the source and thereby the starting point for subsequent steroid synthesis pathways. Most recently, pregnenolone sulfate has been functionally "upgraded" from modulator of ion channels to an activating ion channel ligand. This review will focus on molecular aspects of the neurosteroid, pregnenolone sulfate, its metabolism, concentrations in serum and tissues and last not least will summarize the functional data.

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Section: Pregnenolone Sulfate Levels In Serum and Tissuesmentioning

confidence: 99%

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

Harteneck

2013

Molecules

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“…In fact, protein ubiquitination may be important to understand the proteolytic cascade during breast carcinogenesis [230], improving the knowledge of the proteolytic/antiproteolytic ratio (e.g., MMP/TIMPs balance) [229]. Enterolactone [210] Homocysteine and thiol compounds [223,224] Mitogenic peptides [99,204,225,226] Mutagens [227,228] (2) a cytometric analysis of phenotypic markers of floating cells in BCFs through the identification of peculiar surface antigens (e.g., CD10 and 13 for metalloproteinases, CD11 for integrins, CD30 and 40 for growth factors, CD66 for CEA, etc.) may help to distinguish apocrine metaplasia or different types of apocrine cysts or the relationship between various apocrine cysts and the precancerous epithelial proliferation of the mammary gland.…”

Section: Conundrums Controversies and Future Perspectivesmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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“…Hyperhomocysteinemia has also been related to nutritional deficiency (folate or cobalamin) [13], disease (diabetes) or genetic factors [9,14]. In addition to increased cardiovascular disease risk [6,7], hyperhomocysteinemia is also a risk factor for stroke, tumor [15], Alzheimer's disease and dementia [16].…”

Section: Introductionmentioning

confidence: 99%