Aqueous normal phase chromatography improves quantification and qualification of homocysteine, cysteine and methionine by liquid chromatography–tandem mass spectrometry

Hellmuth, Christian; Koletzko, Berthold; Peißner, Wolfgang

doi:10.1016/j.jchromb.2010.11.016

Cited by 42 publications

(24 citation statements)

References 34 publications

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“…In the EarlyNutrition project, a targeted quantitative metabolomics approach platform was established combining liquid chromatography mass spectrometry approaches and an approach using flow injection analysis coupled to triple mass spectrometry, facilitating the analysis of amino acids, acylcarnitines, phospholipids, and nonesterified fatty acids [9,10,11,12,13,14,15,16]. Using this technology, Wahl et al [17] previously identified 14 serum metabolites with altered concentrations in obese children compared to children of normal weight.…”

Section: Exploration Of Mechanismsmentioning

confidence: 99%

The Power of Programming and the EarlyNutrition Project: Opportunities for Health Promotion by Nutrition during the First Thousand Days of Life and Beyond

et al. 2014

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At The Power of Programming 2014 Conference, researchers from multiple disciplines presented and discussed the effects of early nutrition and other environmental cues during the first thousand days of life and beyond on the lifelong risk of noncommunicable diseases. This paper aims to summarize the concepts and some of the first achievements of the EarlyNutrition research project that initiated the conference.The EarlyNutrition consortium is a multinational, multidisciplinary research collaboration of researchers from Europe, the USA, and Australia. A focus is placed on exploration of the developmental origins of obesity, adiposity, and related health outcomes. Here we report on the first findings of experimental approaches, cohort studies, randomized clinical trials, and systematic reviews of current information, as well as position papers, which have all been developed with the involvement of project partners. We conclude that the EarlyNutrition project has successfully established itself during the first 2 project years as a very strong platform for collaborative research on early programming effects. The first results, available already at this early stage of the project, point to great opportunities for health prevention strategies via the implementation of dietary and lifestyle modifications, with large effect sizes. Further results are expected which should support improved recommendations and related policies for optimized nutrition and lifestyle choices before and during pregnancy, in infancy, and in early childhood.

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Section: Exploration Of Mechanismsmentioning

confidence: 99%

The Power of Programming and the EarlyNutrition Project: Opportunities for Health Promotion by Nutrition during the First Thousand Days of Life and Beyond

et al. 2014

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“…This approach has now become feasible with established high-throughput, precise analytical tools for targeted metabolomic profiling from minimal sample volumes using flow injection analysis with triple-quad mass spectrometry, which is extremely powerful [43,44,45,46,47,48,49]. Application of these sophisticated tools bears the very promising potential to detect relevant but as yet unidentified regulatory substrates involved in the modulation of growth and body composition.…”

Section: Metabolic Mechanismsmentioning

confidence: 99%

Regulation of Early Human Growth: Impact on Long-Term Health

et al. 2014

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Growth and development are central characteristics of childhood. Deviations from normal growth can indicate serious health challenges. The adverse impact of early growth faltering and malnutrition on later health has long been known. In contrast, the impact of rapid early weight and body fat gain on programming of later disease risk have only recently received increased attention. Numerous observational studies related diet in early childhood and rapid early growth to the risk of later obesity and associated disorders. Causality was confirmed in a large, double-blind randomised trial testing the ‘Early Protein Hypothesis'. In this trial we found that attenuation of protein supply in infancy normalized early growth and markedly reduced obesity prevalence in early school age. These results indicate the need to describe and analyse growth patterns and their regulation through diet in more detail and to characterize the underlying metabolic and epigenetic mechanisms, given the potential major relevance for public health and policy. Better understanding of growth patterns and their regulation could have major benefits for the promotion of public health, consumer-orientated nutrition recommendations, and the development of improved food products for specific target populations.

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“…For the unambiguous identification the RT and a qualifier ion ratio (QIR) were used since the ratio between fragments of an analyte is known to be a steady property of the molecule [20,21]. In Table 1 the transitions for each group of analytes are shown.…”

Section: Identificationmentioning

confidence: 99%

Reversed phase LC/MS/MS method for targeted quantification of glycerophospholipid molecular species in plasma

Uhl¹,

Glaser

Demmelmair

et al. 2011

Journal of Chromatography B

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Aqueous normal phase chromatography improves quantification and qualification of homocysteine, cysteine and methionine by liquid chromatography–tandem mass spectrometry

Cited by 42 publications

References 34 publications

The Power of Programming and the EarlyNutrition Project: Opportunities for Health Promotion by Nutrition during the First Thousand Days of Life and Beyond

The Power of Programming and the EarlyNutrition Project: Opportunities for Health Promotion by Nutrition during the First Thousand Days of Life and Beyond

Regulation of Early Human Growth: Impact on Long-Term Health

Reversed phase LC/MS/MS method for targeted quantification of glycerophospholipid molecular species in plasma

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