“…The absorption band of h-ZnS-CdS NC material shifted to more positive (about 500 nm) in comparison with h-ZnS NC (about 350 nm). This positive absorbance shift was corresponded to CdS incorporation into h-ZnS NC [26].…”
Section: Characterization Of Zif-8 Rds Yolk-shelled Zif-8 Rds H-znsmentioning
confidence: 90%
“…After that, ZIF-8 RDs (100.0 mg) was transferred into methanol solution containing TA (2.0 g) under stirring treatment for 10 min. After yolk-shelled ZIF-8 RDs was washed with methanol (50.0 mL), the product was collected via centrifugation at 10,000 rpm [26]. After TAE (1.00 g) solution preparation in ethanol (100.0 mL), this solution was mixed with yolk-shelled ZIF-8 RDs (100.0 mg).…”
Section: Anti-il-6-ab 1 and Antigen Il-6 Immobilization On Qcm Sensormentioning
h i g h l i g h t s g r a p h i c a l a b s t r a c t QCM based immunosensor is developed for Interleukin-6 detection.The prepared immunosensor is characterized by several methods. The prepared immunosensor shows high stability and selectivity. The prepared immunosensor is advantageous in comparison with the other analytical methods.
“…The absorption band of h-ZnS-CdS NC material shifted to more positive (about 500 nm) in comparison with h-ZnS NC (about 350 nm). This positive absorbance shift was corresponded to CdS incorporation into h-ZnS NC [26].…”
Section: Characterization Of Zif-8 Rds Yolk-shelled Zif-8 Rds H-znsmentioning
confidence: 90%
“…After that, ZIF-8 RDs (100.0 mg) was transferred into methanol solution containing TA (2.0 g) under stirring treatment for 10 min. After yolk-shelled ZIF-8 RDs was washed with methanol (50.0 mL), the product was collected via centrifugation at 10,000 rpm [26]. After TAE (1.00 g) solution preparation in ethanol (100.0 mL), this solution was mixed with yolk-shelled ZIF-8 RDs (100.0 mg).…”
Section: Anti-il-6-ab 1 and Antigen Il-6 Immobilization On Qcm Sensormentioning
h i g h l i g h t s g r a p h i c a l a b s t r a c t QCM based immunosensor is developed for Interleukin-6 detection.The prepared immunosensor is characterized by several methods. The prepared immunosensor shows high stability and selectivity. The prepared immunosensor is advantageous in comparison with the other analytical methods.
“…54,55 A Co-MOF@TPN-COF nanoarchitecture has been developed and exploited as novel platforms for an oxytetracycline aptasensor, giving an extremely low LOD of 0.217 fg mL −1 detected by the electrochemical technique, 54,55 much lower than the biosensors for detecting oxytetracycline using other nanomaterials as platforms. 56,57 Thus far, however, there is no report on the construction of the dual-mode PEC−EC biosensors for the detection of HIV-1 based on the core−shell MOF@COF hybrids with π−π stacking interaction and sizable specific surface.…”
Section: Introductionmentioning
confidence: 99%
“…The MOF@COF hybrids can effectively integrate unique advantages of their parents, producing novel porous nanomaterials with outperformed physicochemical properties. , By integrating the aromaticity of MOFs and the ordered pillar–columnar structure characteristics of COFs, the fabricated MOF@COF hybrid materials display a strong π–π stacking interaction, overcoming the inherent disadvantages of sole MOFs and COFs and resulting in a synergistic effect to provide multifunctional properties for specific and personalized applications. Diverse MOF@COF heterostructures have been developed and used as catalysts, − gas adsorbents, supercapacitors, and biosensors. , A Co-MOF@TPN-COF nanoarchitecture has been developed and exploited as novel platforms for an oxytetracycline aptasensor, giving an extremely low LOD of 0.217 fg mL –1 detected by the electrochemical technique, , much lower than the biosensors for detecting oxytetracycline using other nanomaterials as platforms. , Thus far, however, there is no report on the construction of the dual-mode PEC–EC biosensors for the detection of HIV-1 based on the core–shell MOF@COF hybrids with π–π stacking interaction and sizable specific surface.…”
We
developed a novel metal–organic framework (MOF)@covalent–organic
framework (COF) hybrid with a hierarchical nanostructure and excellent
photoactivity, which further acted as the bifunctional platform of
a dual-mode photoelectrochemical (PEC) and electrochemical (EC) biosensor
for detecting HIV-1 DNA via immobilizing the HIV-1 DNA probe. First,
the presynthesized Cu-MOF nanoellipsoids were used as the template
for the in situ growth of the COF network, which was synthesized using
copper-phthalocyanine tetra-amine (CoPc-TA) and 2,9-bis[p-(formyl)phenyl]-1,10-phenanthroline as building blocks through the
Schiff base condensation. In view of the large specific surface area,
abundant reserved amino group, excellent electrochemical activity,
and high photoactivity, the obtained Cu-MOF@CuPc-TA-COF heterostructure
not only can serve as the sensitive platform for anchoring the HIV-1
DNA probe strands but also can be utilized as the signal transducers
for PEC and EC biosensors. Thereby, the constructed biosensor shows
the sensitive and selective analysis ability toward the HIV-1 target
DNA via the complementary hybridization between probe and target DNA
strands. The dual-mode PEC and EC measurements revealed that the Cu-MOF@CuPc-TA-COF-based
biosensor displayed a wide linear detection range from 1 fM to 1 nM
and an extremely low limit of detection (LOD) of 0.07 and 0.18 fM,
respectively. In addition, the dual-mode PEC–EC biosensor also
demonstrated remarkable selectivity, high stability, good reproducibility,
and preferable regeneration ability, as well as acceptable applicability,
for which the detected HIV-1 DNA in human serum showed good consistency
with real concentrations. Thereby, the present work can open a new
dual-mode PEC–EC platform for detecting HIV-1 DNA based on
the porous–organic framework heterostructure.
“…As a new adsorbent, MIPs possessed the advantages of high mechanical stability, good physical and chemical stability, strong selectivity, low cost, and easy preparation. They have been widely used in chemical sensors, − chemical analysis and detection, − chromatographic separation, − and other fields. At present, MIPs are mostly used in the adsorption and separation of various kinds of heavy metals, organics, and sulfur pollutants and other small molecules. − The research is becoming mature.…”
To develop multifunctional protein
imprinted materials, a cobalt-iron
double ion-BSA directional chelation-assisted thermo-sensitive surface-imprinted
hollow nanocage (Co-Fe@CBMA-MIPs) with excellent specificity is developed
on the surface of ZIF-67@Co-Fe in this study by synergizing the advantages
of surface imprinting, metal ion chelation, anti-protein adsorption
segments, and thermo-sensitive components. Beyond previous research,
well-designed multifunctional protein-imprinted materials possess
high binding capacity, fast adsorption kinetics, and outstanding selectivity.
When the adsorption is carried out at 32 °C, the adsorption capacity
of Co-Fe@CBMA-MIPs for BSA reaches 520.35 mg/g within 50 min. The
imprinting factor is 8.55. The selectivity factors of Co-Fe@CBMA-MIPs
for HSA, Bhb, OVA, and Lyz are 3.72, 6.09, 4.10, and 8.41, respectively.
More significantly, Co-Fe@CBMA-MIPs could specifically recognize BSA
from mixed proteins and actual samples and exhibit excellent repeated
use stability. Based on the above advantages, the development of this
research provides an effective means to improve the recognition specificity
of molecularly imprinted polymers.
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