A novel QCM immunosensor development based on gold nanoparticles functionalized sulfur-doped graphene quantum dot and h-ZnS-CdS NC for Interleukin-6 detection

Atar, Necip; Yola, Mehmet Lütfi

doi:10.1016/j.aca.2021.338202

Cited by 60 publications

(27 citation statements)

References 63 publications

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“…Regardless the obvious different protocols used to attach antibodies and aptamers to the different transducer substrates, it is worthy notable that the sensitivity of these devices are really high. Besides, in this recent literature is not rare to observe a trend in using label-free molecules to optimize the fabrication step and to allow accessible in-situ measurements [91][92][93][94][95][96][97][98]. Nonetheless, it is also evident that many authors have employed electrochemical techniques to ensure accuracy and high performance of biosensors, corroboration the previous discussion brought to this minireview in the section "Recent trends in biosensors for detection of analytes of medical interest".…”

Section: Efficiency Of Immunosensors and Aptasensorssupporting

confidence: 59%

Mof@Mos2-Based Electrochemical Biosensor for Ca125 Detection

Weifeng¹

2020

BJSTR

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Antibodies and aptamers play a crucial role to improve the analytical performance of biosensors for medical applications. Besides their natural compatibility with many antigens and pathogens, their biochemical structure selectively binds the analyte providing high sensitivity and selectivity. Accordingly, this minireview presents the recent approaches in the field of immunosensors and aptasensors for clinical diagnoses with a focus on the key features of sensors over the conventional diagnostic assays and the trends in this field of knowledge (point-of-care devices for in situ applications, label-free bioreceptors, real-time monitoring of analytes and outstanding transduction techniques).

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Section: Efficiency Of Immunosensors and Aptasensorssupporting

confidence: 59%

Mof@Mos2-Based Electrochemical Biosensor for Ca125 Detection

Weifeng¹

2020

BJSTR

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“…The quartz crystal microbalance (QCM) has been widely used in many fields, including analytical chemistry, − immunology, , and drug development, , due to its high-quality factor and high sensitivity. However, in practical applications, the sample to be tested cannot be uniformly and rigidly distributed on the entire electrode surface of the QCM, which leads to low repeatability of the measurement results.…”

Section: Introductionmentioning

confidence: 99%

Uniform Mass Sensitivity Distribution of Elliptically Designed Electrodes Based on a Quartz Crystal Microbalance

Jiang

Tang

2021

ACS Omega

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Uniformization of mass sensitivity distribution is conducive to the application of the quartz crystal microbalance (QCM) in some fields. However, the sensitivity of the QCM sensor surface perpendicular to the displacement direction is higher that of the displacement direction in the mass sensitivity distribution of ring and double-ring QCMs, which leads to poor reproducibility of the sensor. Considering the effect of the electrode structure on the mass sensitivity distribution, we found that for ring- and double-ring-type QCMs, when the elliptical single ring and double-ring electrode structures are combined, an approximately uniform mass sensitivity can be obtained in all directions. Therefore, this study proposes the elliptical single-ring and elliptical double-ring electrode structure design. Through theoretical calculations and three-dimensional finite element analysis verification, a systematic investigation is carried out to quantify the effect of the ratio of the minor axis to the major axis of the elliptical electrode on the mass sensitivity distribution in different directions, and the optimal ratio is found to be 0.8. Comparing the mass sensitivity of the new type of electrodes and the original electrodes, the result shows that the mass sensitivity distribution of the elliptical double-ring electrode structure is more uniform. Hence, these specially designed electrodes are conducive to improving the repeatability.

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“…Finally, ester groups were replaced by amine groups of primary antibodies (Ab1), which resulted in the immobilization of Ab1 on the SAW surface as a SAM layer. The immobilization of Ab1 on the sensor surface was characterized by QCM frequency measurements based on previous reports [28]. Figure 4A The elemental composition of MoS 2 @Cu 2 O-Au was characterized by SEM-EDS elemental mapping, as shown in Figure S1.…”

Section: Preparation and Characterization Of Self-assembled Monolayer (Sam)mentioning

confidence: 99%

“…To date, a wide variety of signal amplification systems have been reported for immunosensors, including strategies based on metal oxides, enzymes, noble metal nanoparticles, and nanocomposite materials [26][27][28]. Among the metal oxides, Cu 2 O has attracted significant attention as a promising candidate for the fabrication of biosensors owing to its environmental compatibility, low cost, and large surface area [29].…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Leaky Surface Acoustic Wave Immunosensor for Real-Time Detection of Alpha-Fetoprotein in Biological Fluids

et al. 2021

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We propose an ultrasensitive leaky surface acoustic wave (LSAW) immunosensor based on molybdenum disulfide @ cuprous oxide—gold (MoS2@Cu2O-Au) nanoparticles and subsequent gold staining for the detection of alpha-fetoprotein (AFP). MoS2@Cu2O-Au nanoparticles, with their large specific surface area and good biocompatibility, not only capture the secondary antibodies (Ab2) but also amplify the mass loading effect of the acoustic wave sensor in the detection of AFP. The immunosensor signals are further amplified upon injection of gold staining solution. The developed immunosensor achieved a low detection limit of 5.5 and 25.0 pg/mL with and without gold staining, respectively. The immunosensor demonstrated its efficiency for the quantitative detection of AFP in complex biological fluids, including human serum and saliva samples, with excellent selectivity and long-term stability, showing great potential for the quantification of AFP in clinical diagnosis.

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A novel QCM immunosensor development based on gold nanoparticles functionalized sulfur-doped graphene quantum dot and h-ZnS-CdS NC for Interleukin-6 detection

Cited by 60 publications

References 63 publications

Mof@Mos2-Based Electrochemical Biosensor for Ca125 Detection

Mof@Mos2-Based Electrochemical Biosensor for Ca125 Detection

Uniform Mass Sensitivity Distribution of Elliptically Designed Electrodes Based on a Quartz Crystal Microbalance

Ultrasensitive Leaky Surface Acoustic Wave Immunosensor for Real-Time Detection of Alpha-Fetoprotein in Biological Fluids

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