Hollow mesoporous hydroxyapatite nanostructures; smart nanocarriers with high drug loading and controlled releasing features

Munir, Muhammad Usman; Ihsan, Ayesha; Sarwar, Yasra; Bajwa, Sadia Z.; Bano, Khizra; Tehseen, Bushra; Zeb, Neelam; Hussain, Irshad; Ansari, Muhammad Tayyab; Saeed, Madiha; Li, Juan; Iqbal, M. Zubair; Wu, Aiguo; Khan, Waheed S.

doi:10.1016/j.ijpharm.2018.04.029

Cited by 40 publications

(27 citation statements)

References 51 publications

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“…The bands at 563 and 603 cm −1 came from v 4 bending vibrations of PO 4 3− , and the bands at 873 cm −1 came from v 1 symmetrical stretching vibration of PO 4 . The strong band at 1035 cm −1 also belongs to the stretching vibration of PO 4 [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The broad peaks at 3448 cm −1 and 1635 cm −1 belong to the adsorbed water in HAP samples.…”

Section: Preparation Of Micro/nano-sized Hap By Tea Cappingmentioning

confidence: 99%

“…In addition to the above advantages, HAPs have the following advantages: (1) HAPs usually have a long biodegradation time and can be retained for a long time after administration without the transient release of the drug, so that the drug release can be controlled at the lowest effective concentration for a long time, avoiding the issues of repeated administration and high-dose side effects [12]; (2) the crystal structure of a HAP is hexagonal and it has two different binding sites, namely the negatively-charged P site and the positively-charged Ca site. These characteristics make HAPs a good adsorbent that can bind to many substances, including proteins, antitoxins, and growth factors [13]; (3) by applying doping techniques, HAPs can be prepared as particles with good electrical properties (such as ferroelectric and dielectric properties) [14], mechanical properties (such as piezoelectric property, ultrahigh hardness) [15], magnetic properties (such as superparamagnetism) [16] and optical properties (such as photothermal effect, electroluminescence) [17]. It is rare for polymer particles to possess these properties; (4) The mesoporous structure of HAPs can protect and maintain the conformation of protein molecules, preventing protein molecules from denaturation and agglomeration in certain extreme environments [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improvement of Drug-Loading Properties of Hydroxyapatite Particles Using Triethylamine as a Capping Agent: A Novel Approach

Wen

Lin

et al. 2021

Crystals

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Particles that modify delivery characteristics are a focus of drug-loading research. Hydroxyapatite particles (HAPs) have excellent biocompatibility, shape controllability, and high adsorption, making them a potential candidate for drug-delivery carriers. However, there are still some defects in the current methods used to prepare HAPs. In order to avoid agglomeration and improve the drug-loading properties of HAPs, the present study provides a novel triethylamine (TEA)-capped coprecipitation template method to prepare HAPs at room temperature. In addition, pure water and anhydrous ethanol were used as solvents to investigate the capping effect of the small-molecule capping agent TEA during the synthesis of HAPs. The results showed that the HAPs prepared in the TEA ethanol system had a smaller particle size (150–250 nm), better dispersion and higher crystallinity. The results were significantly different from those of the conventional preparation methods without TEA. However, the hydroxyapatite crystal would agglomerate to a certain extent after being stored for a period of time, forming micro/nano-sized agglomerates of nanocrystals. FITR analysis and SEM observation showed that the capping effect of TEA promoted the formation of a smaller template and dispersed HAPs were quickly formed by dissolution and reprecipitation processes. The drug-loading experiments showed that the HAPs prepared in the TEA ethanol system had high drug-loading capacity (239.8 ± 13.4 mg·g−1) as well as an improved drug-release profile demonstrated in the drug-release experiment. The larger specific surface area associated with the smaller particle size was beneficial to the adsorption of drugs. After drying at 60 °C, TEA was evaporated from the HAPs which agglomerated into larger micron particles with more drug encapsulated. Thus, the effect of a sustained release was achieved. In the present research, a novel approach was developed by using triethylamine as the capping agent to prepare micro/nano-sized agglomerates of HAP nanocrystals with improved drug loading, which is predicted to have potential application in drug delivery.

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Section: Preparation Of Micro/nano-sized Hap By Tea Cappingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvement of Drug-Loading Properties of Hydroxyapatite Particles Using Triethylamine as a Capping Agent: A Novel Approach

Wen

Lin

et al. 2021

Crystals

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“…The inner space of M-HANPs contains a large number of voids, which can serve as drug storage sites; at the same time, the hollow shell acts as a permeation barrier to limit the burst release of drugs [28,[54][55][56]. Munir et al (2018) compared the effect of hollow and solid M-HANPs loaded with ciprofloxacin (CFC) [57]. The pore size distribution of the hollow M-HANP is narrow, about 3.6 nm, while the pore size distribution of the solid M-HANP is wider, about 22.58 nm.…”

Section: Effect Of Ha Structure On Drug Adsorptionmentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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“…64,65 Similarly, resistance development can be prevented by encapsulating various antibiotics within same NMs. 66,67 Existing tolerance mechanisms like lower uptake and higher drug efflux, intracellular bacteria and development of biofilm can also be inhibited through NMs. 16 Antimicrobial drugs aimed at infectious area via NMs and assisting larger amount of dose to reach the diseased site.…”

Section: Nanomaterials Mechanisms To Combat Bacterial Resistancementioning

confidence: 99%

“…182 NMs Targeting Antimicrobials at the Infected Site Lastly, NMs target antimicrobials at the infectious area, consequently more drugs can reach the target area and overwhelming the resistance methods. 19,66 Similar to the NMs targeting intracellular bacteria, NMs targeting infectious site may release a high amount of antimicrobials at infectious area keeping the total drug dose administered low. Intracellular microbe not survived before developing resistance by high local dose at the infectious area.…”

Section: Nms Combating Intracellular Bacteriamentioning

confidence: 99%

<p>Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes</p>

Munir

Ahmed

Usman

et al. 2020

IJN

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The ongoing escalation of drug-resistant bacteria creates the leading challenges for human health. Current predictions show that deaths due to bacterial illness will be more in comparison to cancer in 2050. Irrational use of antibiotics, prolonged regimen and using as a prophylactic treatment for various infections are leading cause of microbial resistance. It is an emerging approach to introduce evolving nanomaterials (NMs) as a base of antibacterial therapy to overcome the bacterial resistance pattern. NMs can implement several bactericidal ways and turn into a challenge for bacteria to survive and develop resistance against NMs. All the pathways depend on the surface chemistry, shape, core material and size of NMs. Because of these reasons, NMs based stuff shows a critical role in advancing the treatment efficiency by interacting with the cellular system of bacteria and functioned as an antibiotic substitute. We divided this review into two sections. The first part highlights the development of microbial resistance to antibiotics and their mechanisms. The second section details the NMs mechanisms to combat antibiotic resistance. In short, we try to summarize the advances in NMs role to deal with microbial resistance and giving solution as antibiotics substitute.

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Hollow mesoporous hydroxyapatite nanostructures; smart nanocarriers with high drug loading and controlled releasing features

Cited by 40 publications

References 51 publications

Improvement of Drug-Loading Properties of Hydroxyapatite Particles Using Triethylamine as a Capping Agent: A Novel Approach

Improvement of Drug-Loading Properties of Hydroxyapatite Particles Using Triethylamine as a Capping Agent: A Novel Approach

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

<p>Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes</p>

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