Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

“…In addition to the promising imaging property, theranostic nanoparticles have been produced to carry a single therapeutic agent or the combination of two or more drugs [80,81], including chemotherapy drugs, small-molecule agents, photosensitizers and siRNAs. Significant advantages of nanoparticle-formulated drug delivery include: first, increasing the effective drug dose by selective delivery of a large amount of drug molecules, especially highly insoluble drug-loaded nanoparticles, into the tumor while reducing systemic side effects [82]; second, protecting drug molecules or biological therapeutic agents (siRNAs or peptides) from degradation before reaching target tissues and cells [83] and third, targeted delivery through cell receptors that bypasses multidrug-resistant mechanisms on the tumor cell membrane [84]. For example, gold-coated IONPs with cisplatin were used to treat human ovarian cancer cell lines and tested for the drug delivery efficiency [85].…”

“…Recent studies have demonstrated the ability of overcoming drug-resistant mechanism on the tumor cell membrane by nanoparticle-mediated internalization of nanoparticle-drug complexes. It has been shown that hollow IONPs modified with human serum albumin and incorporated with DOX had a significantly higher level of intratumoral cell nanoparticle-DOX delivery compared with conventional DOX treatment in a multidrug-resistant human ovarian cancer OVCAR8-ADR cell line [84]. This might be a result of decreased efflux of nanoparticle-drugs by P-glycoprotein that locates on the cellular membrane and transports drug molecules out of cells.…”

Chemical synthesis and characterization of hollow dopamine coated, pentagonal and flower shaped magnetic iron oxide nanoparticles

“…Hollow, porous and core shell iron oxide nanoparticles have been synthesized by the thermal decomposition method that has been reported elsewhere [6,22,23]. 13nm core/shell nanoparticles were synthesized.…”

pH‐Responsive Drug‐Delivery Systems

“…Xing et al [85] used the dopamine plus human serum albumin method to modify hollow iron oxide nanoparticles and load DOX within them, and this system could load more drug than solid iron oxide nanoparticles of the same core size by using the same coating strategy. The hollow iron oxide nanoparticle drug-delivery system had a pH-dependent drug release behavior with faster release kinetics at lower pH values.…”