pH‐Responsive Drug‐Delivery Systems

Zhu, Yingjie; Chen, Feng

doi:10.1002/asia.201402715

Cited by 161 publications

(106 citation statements)

References 117 publications

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“…A. Entezami (&) Laboratory of Polymer, Faculty of Chemistry, University of Tabriz, Tabriz, Iran e-mail: aentezami@tabrizu.ac.ir assists the release of drug either in relatively acidic extracellular fluids or, after endocytosis in endosomes or lysosomes of tumor cells. Hence, it is anticipated that the pH-responsive drug-delivery systems will show a main role in applications in new horizons of cancer therapy (Zhu and Chen 2015). In addition, the temperature of tumor tissues have been reported to be a bit more than normal cells around 40°C.…”

Section: Introductionmentioning

confidence: 99%

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

et al. 2015

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In this work, a thermo and pH-responsive poly-N-isopropylacrylamide-co-itaconic acid containing thiol side groups were successfully synthesized to prepare Doxorubicin-loaded polymer@Au/ Fe 3 O 4 core/shell nanoparticles (DOX-NPs). Copolymer and NPs were fully characterized by FT-IR, HNMR, photo-correlation spectroscopy, SEM, X-ray diffraction, vibrating-sample magnetometer, thermal gravimetric analysis, and UV-Vis spectroscopy. The stimuli-responsive characteristics of NPs were evaluated by in vitro release study in simulated cancerous environment. The biocompatibility and cytotoxic properties of NPs and DOX-NPs are explored by MTT method. The prepared NPs with the size of 50 nm showed paramagnetic characteristics with suitable and stable dispersion at physiological medium and high loading capacity (up to 55 %) of DOX. DOX-NPs yielded a pH-and temperaturetriggered release of entrapped drugs at tumor tissue environment (59 % of DOX release) compared to physiological condition (20 % of DOX release) during 48 h. In vitro cytotoxicity studies indicated that the NPs showed no cytotoxicity on A549 cells at different amounts after incubation for 72 h confirming its suitability as a drug carrier. DOX-NPs, on the other hand, caused an efficient anticancer performance as verified by MTT assay test. It was concluded that developed NPs by us in this study may open the possibilities for targeted delivery of DOX to the cancerous tissues.

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Section: Introductionmentioning

confidence: 99%

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

et al. 2015

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“…We published a review article to discuss some recent progress obtained for pH-responsive drug delivery systems and future perspectives. [109] …”

Section: Drug Deliverymentioning

confidence: 99%

Nanostructured Materials of Calcium Phosphates and Calcium Silicates: Synthesis, Properties and Applications

Zhu

2017

Chin. J. Chem.

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4-) and sometimes hydrogen or hydroxide ions. Calcium phosphates can be widely found in nature as well as in hard tissues (bone and tooth) of the vertebrate. Owing to similar chemical composition and structure to the main inorganic constituents of bone and tooth, calcium phosphate-based materials are promising biomaterials with high biocompatibility, and have been investigated for applications in various biomedical areas. Calcium silicate-based materials have attracted much attention on their potential applications in various biomedical fields such as bone defect repair and drug delivery. In recent years, this research group has been focusing on the research in this exciting and rapidly evolving research field, and has published many papers. This article will provide a brief review on our main research work on the synthesis, characterization, properties and applications of nanostructured materials of calcium phosphates and calcium silicates. Finally, future perspectives and challenges for the research and applications of nanostructured materials of calcium phosphates and calcium silicates are discussed.

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“…Target proteins such as herceptin can be conjugated on the surface of MNPs to facilitate their active delivery to breast tumors [15][16][17][18]. The design and fabrication of elaborate and advanced MNP-based DDSs is a promising approach to controlled loading and accurate multistep delivery [19].…”

Section: Introductionmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

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pH‐Responsive Drug‐Delivery Systems

Cited by 161 publications

References 117 publications

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

Nanostructured Materials of Calcium Phosphates and Calcium Silicates: Synthesis, Properties and Applications

Magnetic drug delivery systems

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