Hollow hierarchical hydroxyapatite/Au/polyelectrolyte hybrid microparticles for multi-responsive drug delivery

Xu, Shungang; Shi, Jun; Feng, Desheng; Yang, Lijun; Cao, Shaokui

doi:10.1039/c4tb01066c

Cited by 53 publications

(32 citation statements)

References 41 publications

(64 reference statements)

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“…A popular and productive approach to multiresponsive materials is to integrate different reactive moieties into individual polymer chains, often taking advantage of controlled and living polymerization techniques . Films prepared by the LbL technique can also respond to multiple stimuli, such as polymer/clay LbL films, polymer/gold nanoparticles multilayers, composites of poly(ethylene glycol)‐functionalized nanoparticles and photochromic polymers, and capsules comprising star polyelectrolytes . This communication describes several examples of an approach to designing multiresponsive LbL films that relies on compartmentalizing chemistry in stratified polyelectrolyte multilayer (PEM) films such that different external stimuli perform different functions.…”

Section: Methodssupporting

confidence: 86%

Stimuli‐Responsive Free‐Standing Layer‐By‐Layer Films

McIntosh

Simon

et al. 2015

Advanced Materials

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Free-standing, stimuli-responsive polyelectrolyte multilayer films enabled by light-induced degradation of sacrificial compartments are introduced. Two examples are described: i) a triple responsive film that uses light, redox, and pH for different functions, and ii) different wavelengths of light for different functions. This approach to multiresponsive materials offers simple design and chemical synthesis while enabling different stimuli to perform separate functions in the same material.

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Section: Methodssupporting

confidence: 86%

Stimuli‐Responsive Free‐Standing Layer‐By‐Layer Films

McIntosh

Simon

et al. 2015

Advanced Materials

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“…The generation mechanism of pseudocapacitance performance by N‐5 and N‐6 can be described as follows according to the possible following faradic reactions [Eqs. (6) and ]:

true^{*} CH - NH_{2} + 2 OH^{-} \leftrightarrow^{*} normalC = NH + 2 H_{2} normalO + 2 e^{-}

true^{*} normalC - NH_{2} + 2 OH^{-} \leftrightarrow^{*} normalC - NHOH + normalH_{2} normalO + 2 e^{-}

…”

Section: Resultsmentioning

confidence: 99%

Nitrogen‐Doped Hierarchical Porous Carbon Framework Derived from Waste Pig Nails for High‐Performance Supercapacitors

Zhou

Ren

et al. 2017

ChemElectroChem

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In situ nitrogen‐doped hierarchical porous carbon was synthesized by using waste protein‐rich pig nails as precursors in a facile KOH activation method. The microstructure and electrochemical characteristics of the materials were investigated by tuning the amount of KOH. When the weight ratio of KOH to pig nails is 1 : 1, the obtained nitrogen‐doped hierarchical porous carbon (NHPC‐1) exhibits the largest specific surface area (2569 m2 g−1) with interconnected porous network structure, which are beneficial to ion/electron storage and transfer. In addition, abundant nitrogen of 2.8 at % in the NHPC‐1 also contributes to the high electrochemical activity of the supercapacitor during the charging/discharging process. As a result, the NHPC‐1 electrode in the supercapacitor exhibits a high specific capacitance of 231 F g−1 at 1 A g−1 and superior retention of 98 % after 5000 cycles at 1 A g−1 in 6 M KOH electrolyte. Additionally, the assembled symmetric device based on NHPC‐1 exhibits a high energy density of 7 Wh kg−1 at a power density of 500 W kg−1. Our study suggests that waste pig nails can act as low‐cost and renewable carbon precursors for high performance supercapacitor.

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“…It could be found that the surface of MnCO 3 microparticles was very coarse. [35][36][37] It should also be noted that the total released DOX amount were relatively low for all studied pH conditions. Prior to laser irradiation, the microcapsules were spherical in solution but resembled deflated balloons after being dried for microscopic analysis [ Figure 3( microparticles, indicating the incorporation of polyelectrolyte multilayers around the MnCO 3 template.…”

Section: Aggregation Of Au Nanoparticlesmentioning

confidence: 83%

Hollow PUA/PSS/Au microcapsules with interdependent near‐infrared/pH/temperature multiresponsiveness

Shi

Liu

et al. 2015

J of Applied Polymer Sci

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In this work, smart hollow microcapsules made of thermal-/pH-dual sensitive aliphatic poly(urethane-amine) (PUA), sodium poly(styrenesulfonate) (PSS), and Au nanoparticles (AuNPs) for interdependent multi-responsive drug delivery have been constructed by layer-by-layer (LbL) technique. The electrostatic interactions among PUA, PSS, and AuNPs contribute to the successful self-assembly of hollow multilayer microcapsules. Thanks to the shrinkage of PUA above its lower critical solution temperature (LCST) and the interaction variation between PUA and PSS at different pH conditions, hollow microcapsules exhibit distinct pHand thermal-sensitive properties. Moreover, AuNPs aggregates can effectively convert light to heat upon irradiation with near-infrared (NIR) laser and endow the hollow microcapsules with distinct NIR-responsiveness. More importantly, the NIR-responsive study also demonstrates that the microcapsule morphology and the corresponding NIR-responsive drug release are strongly dependent on the pH value and temperature of the media. The results indicate that the prepared hollow PUA/PSS/Au microcapsules have the great potential to be used as a novel smart drug carrier for the remotely controllable drug delivery. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym.Sci. 2016, 133, 43008.

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Hollow hierarchical hydroxyapatite/Au/polyelectrolyte hybrid microparticles for multi-responsive drug delivery

Abstract: Hollow hierarchical hydroxyapatite/Au/polyelectrolyte hybrid microparticles with a hollow HAP core and polymer multilayer/Au nanoparticle shell for multi-responsive drug delivery have been prepared via an LbL technique.

Cited by 53 publications

References 41 publications

Stimuli‐Responsive Free‐Standing Layer‐By‐Layer Films

Stimuli‐Responsive Free‐Standing Layer‐By‐Layer Films

Nitrogen‐Doped Hierarchical Porous Carbon Framework Derived from Waste Pig Nails for High‐Performance Supercapacitors

Hollow PUA/PSS/Au microcapsules with interdependent near‐infrared/pH/temperature multiresponsiveness

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