Hodgkin's disease‐like lesions in the dog

Wells, G. A. H.

doi:10.1002/path.1711120103

Cited by 20 publications

(9 citation statements)

References 5 publications

(4 reference statements)

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“…Hodgkin's lymphoma (HD) in humans is a slowly progressive neoplasm of lymphocytic origin that arises in a single, axial group of nodes and spreads via contiguous nodes; extranodal involvement is uncommon 2 . Isolated cases of Hodgkin's‐like lymphoma have been described in the veterinary literature 3–8 . One report of 20 cats suggests that Hodgkin's‐like lymphoma in this species appears to involve primarily the lymph nodes of the head and neck 1 …”

Section: Discussionmentioning

confidence: 99%

“…2 Isolated cases of Hodgkin's-like lymphoma have been described in the veterinary literature. [3][4][5][6][7][8] One report of 20 cats suggests that Hodgkin's-like lymphoma in this species appears to involve primarily the lymph nodes of the head and neck. 1 In the cat reported here, multiple peripheral enlarged lymph nodes and a solitary conjunctival mass were present.…”

Section: Discussionmentioning

confidence: 99%

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Extranodal conjunctival Hodgkin's‐like lymphoma in a cat

Holt

Goldschmidt

Skorupski

2006

Veterinary Ophthalmology

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A seven-year-old female spayed Domestic Short-haired cat was brought for examination following a four-month history of conjunctivitis in the right eye. The superior palpebral conjunctiva was diffusely swollen and firm, displacing the right globe ventrally and preventing full closure of the eyelids. The right popliteal lymph node was enlarged as were several other peripheral lymph nodes. An incisional biopsy of the conjunctival swelling revealed a lymphoid neoplasm, the cellular make up of which suggested features of feline Hodgkin's-like lymphoma. Although the neoplasm was poorly responsive to standard chemotherapeutic protocols for lymphoma, radiation therapy rapidly reduced its size. Three years following the initial diagnosis, there has been no recurrence of the conjunctival neoplasm. To the authors' knowledge, there are no previous reports of extranodal or adnexal (conjunctiva, eyelid, orbit) Hodgkin's-like lymphoma in the veterinary literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extranodal conjunctival Hodgkin's‐like lymphoma in a cat

Holt

Goldschmidt

Skorupski

2006

Veterinary Ophthalmology

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“…Hodgkin's lymphoma is a common neoplasm in young adult humans and a similar condition has been reported sporadically in the cat, dog, killer whale, skunk and rat. 1,[3][4][5][6][7][8] Hodgkin's lymphoma in people arises from transformed germinal-center B cells or post-germinalcenter B cells, i.e., memory B cells that no longer undergo somatic mutation of their Ig gene. This was demonstrated by the detection of clonal IgV gene rearrangements in isolated neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Cervical mass in a cat

Steinberg¹,

Keating²

2008

Veterinary Clinical Pathol

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An 8-year-old female spayed domestic shorthair cat was presented for several months of weight loss, decreased appetite, and 2 bilateral, ventral cervical masses. Initial cytologic samples were interpreted as reactive lymphoid hyperplasia. Evaluation of subsequent mass aspirates revealed small numbers of large binucleated and multinucleated cells resembling Reed-Sternberg cells admixed with more numerous small and intermediate-sized lymphocytes. In histopathologic sections, the normal architecture of the lymph node was largely effaced by a slightly heterogeneous mass composed of round cells arranged in densely cellular sheets with a minor population of large (25-microm diameter) mononuclear cells and a few very large (30-40-microm diameter) binucleated or multinucleated cells interpreted as Reed-Sternberg-like cells. Immunohistochemically, the large neoplastic (Reed-Sternberg-like) cells were negative for CD18, CD3, CD20, and CD79a while the background population consisted of about 70% T cells and 30% B cells. This pattern of immunohistochemical staining along with cytologic and histopathologic findings supported a diagnosis of Hodgkin's-like lymphoma, specifically, the lymphocyte-rich subtype. Hodgkin's-like lymphoma has been reported previously in cats and should be suspected when Reed-Sternberg-like cells are observed in cytologic preparations of lymph node aspirates. Histopathology and immunohistochemistry are necessary for a definitive diagnosis.

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“…A doença de Hodgkin é diagnosticada pela presença da célula de Reed-Sternberg, que é multinucleada, às vezes com núcleo com imagem em espelho, sendo que cada núcleo possui um nucléolo gigante (RAPAPORT, 1990a;BAIN, 1995). Essa forma ainda é insuficientemente descrita em cães (WELLS, 1974;MAEDA et al, 1993). Uma classificação de linfoma bastante utilizada em medicina veterinária é baseada na localização das massas tumorais, isto é: multicêntrico, mediastínico, alimentar e misto (MOULTON & HARVEY, 1990).…”

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