Extranodal conjunctival Hodgkin's‐like lymphoma in a cat

Holt, Elaine; Goldschmidt, Michael H.; Skorupski, Katherine A

doi:10.1111/j.1463-5224.2006.00451.x

Cited by 19 publications

(15 citation statements)

References 12 publications

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“…60 Data for dogs and cats in the present study should be carefully compared with data for humans because only 4 animals with conjunctival lymphoma were identified in this study and that problem had a very low prevalence (0.08% of all lymphoma patients at our institution). However, similar to humans, 3 of 4 patients in the present study and 2 domestic animals in other reports 9,12 had conjunctivitis that was unresponsive to topical treatment. Unlike humans, however, T-cell lymphoma was the most common phenotype detected in the present study; 2 dogs had conjunctival CETL.…”

Section: Discussionmentioning

confidence: 41%

“…Although intraocular lymphoma has been described for dogs and cats, [5][6][7][8] a lack of systemic involvement was confirmed by necropsy in only 1 case report for a dog with uveal lymphoma that died as a result of vehicular trauma following enucleation of the neoplastic eye. 5 Conjunctival lymphoma in dogs and cats has also been reported; [9][10][11][12][13][14] however, a lack of systemic involvement was confirmed for dogs in only 2 reports. 11,14 Likewise, intraocular and primary conjunctival lymphomas each represent approximately 1% of non-Hodgkin' s lymphomas in humans.…”

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confidence: 99%

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Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL). Design—Retrospective case series. Animals—7 dogs and 2 cats with PSOL. Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined. Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

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Section: Discussionmentioning

confidence: 41%

mentioning

confidence: 99%

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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“…14 In the current study, there were 1 T-cell lymphoma and 2 B-cell lymphomas. Epitheliotropism was not obvious in any tumor.…”

Section: Discussionmentioning

confidence: 99%

“…17 More recently, there have been isolated case reports and case series describing apocrine hidrocystomas (AHCs), hemangiomas, HSAs, lymphomas, and peripheral nerve sheath tumors (PNSTs) in the eyelids of cats. 3,5,[12][13][14]20,22 The current report describes the feline eyelid tumors submitted to the University of Tennessee between June 1999 and June 2008.…”

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confidence: 99%

A Retrospective Study of Eyelid Tumors from 43 Cats

Newkirk

Rohrbach

2009

Vet Pathol

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Abstract. Submissions to the University of Tennessee pathology service from June 1999 to June 2008 were searched for feline cases of tumors involving the eyelids or nictitans. Forty-three tumors were identified. The average age at diagnosis was 10.4 years. Significantly more males than females had eyelid tumors. There were 12 squamous cell carcinomas (SCCs), 11 mast cell tumors (MCTs), 6 hemangiosarcomas (HSAs), 4 adenocarcinomas (ACAs), 3 peripheral nerve sheath tumors (PNSTs), 3 lymphomas, 3 apocrine hidrocystomas (AHCs), and 2 hemangiomas. Cats with MCTs were significantly younger than cats with all other tumor types combined. In contrast, cats with SCCs were significantly older than cats with other tumor types. The HSAs and SCCs were significantly more likely than other tumors to occur in nonpigmented areas. The MCTs, HSAs, AHCs, and hemangiomas did not recur after surgical excision. In contrast, the lymphomas, ACAs, SCCs, and PNSTs frequently recurred and/or resulted in death or euthanasia of the cat. The SCCs were significantly more likely to recur than the MCTs. The average survival time for cats with SCCs was 7.4 months. Although eyelid MCTs have been reported in cats, the prevalence in this study is much higher than previously described.

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“…6 A cat with a conjunctival Hodgkin's-like lymphoma has also been reported, although this cat had concurrent lymphadenopathy for an unknown reason. 8 Hodgkin's-like lymphoma appears to have a better prognosis than non-Hodgkin's lymphoma, whereby surgical resection of affected lymph nodes has been reported to be curative in both humans and animals. 15,25 The phenomenon of cancer regression in humans is well known; it was first reported in the literature in 1899 with many subsequent reports since then.…”

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confidence: 99%

Extra-nodal subcutaneous Hodgkin’s-like lymphoma and subsequent regression in a cat

Newton

Vicente

Haugland³

et al. 2014

Journal of Feline Medicine and Surgery

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Hodgkin's-like lymphoma is a slow growing neoplasm, usually affecting the lymph nodes of the head and neck, which has been sporadically described in veterinary patients. This report describes the clinical and histopathological features in a 9-year-old male neutered Siamese cat that presented with a 6 week history of mid-dorsocranial swelling. Immunohistochemistry demonstrated positive staining for CD79a, paired box protein and B lymphocyte antigen-36, with variable, weak-to-moderate cytoplasmic staining for human leukocyte antigen-DR and CD18, and negative staining for antimacrophage antibody. The diagnosis based on incisional biopsy was Hodgkin's-like lymphoma; however, no evidence of neoplasia was found following wide surgical excision. This case report demonstrates two unreported items of note: the novel extranodal site of Hodgkin's-like lymphoma in a cat and tumour regression following initial biopsy. It is hypothesised that the surgical trauma of biopsying the lesion or the introduction of foreign material may have caused the regression of the neoplastic cells through induction of an anti-tumour immune or inflammatory response.

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Extranodal conjunctival Hodgkin's‐like lymphoma in a cat

Cited by 19 publications

References 12 publications

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

A Retrospective Study of Eyelid Tumors from 43 Cats

Extra-nodal subcutaneous Hodgkin’s-like lymphoma and subsequent regression in a cat

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