Extra-nodal subcutaneous Hodgkin’s-like lymphoma and subsequent regression in a cat

Abstract

Hodgkin's-like lymphoma is a slow growing neoplasm, usually affecting the lymph nodes of the head and neck, which has been sporadically described in veterinary patients. This report describes the clinical and histopathological features in a 9-year-old male neutered Siamese cat that presented with a 6 week history of mid-dorsocranial swelling. Immunohistochemistry demonstrated positive staining for CD79a, paired box protein and B lymphocyte antigen-36, with variable, weak-to-moderate cytoplasmic staining for human leukocyte antigen-DR and CD18, and negative staining for antimacrophage antibody. The diagnosis based on incisional biopsy was Hodgkin's-like lymphoma; however, no evidence of neoplasia was found following wide surgical excision. This case report demonstrates two unreported items of note: the novel extranodal site of Hodgkin's-like lymphoma in a cat and tumour regression following initial biopsy. It is hypothesised that the surgical trauma of biopsying the lesion or the introduction of foreign material may have caused the regression of the neoplastic cells through induction of an anti-tumour immune or inflammatory response.

Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat

“…[36][37][38] There is no available literature that allows a comparison of this haematic value between non-epitheliotropic cutaneous lymphoma localised in the tarsal region and the form described in this report. As reported for other neoplastic conditions in cats, 39 in our case report radiographs of the thorax and abdomen were unremarkable, as was the abdominal ultrasound. In dogs, the majority of cutaneous non-epitheliotropic lymphomas exhibit rapid progression and metastasis to draining lymph nodes and subsequent systemic involvement.…”

CD30 Cross-Reactivity and Expression in Feline Normal Tissues and Lymphomas

“…4,6,7,17 –19,33,36,42 Although CD30 was variably identified in subsets of human DLBCL and peripheral T-cell lymphoma not otherwise specified, the diagnostic and prognostic role of CD30 in these cases is still a matter of debate. 14,16,18,24…”

“…6,18,26,29,30,32 CD30 expression is consistently included in the diagnostic workup of human lymphomas for the specific identification of 3 groups of lymphoid neoplasms comprising classical Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and primary cutaneous CD30 þ T-cell lymphoproliferative disorders. 6,18,21,24,26,32 Other lymphoma types, such as diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma, peripheral T-cell lymphoma, mycosis fungoides, and adult T-cell leukemia/lymphoma, variably express CD30 with variable diagnostic and prognostic implications. 6,[18][19][20]29,35 Recently, studies regarding CD30 expression in human lymphomas have increased exponentially owing to its relevance as a therapeutic target due to its unique tissue distribution pattern.…”

Temporary spontaneous regression of feline non‐Hodgkin’s lymphoma

“…Among the lymphomas, SR has been reported mostly in patients with low‐grade NHL, but some cases are reported among intermediate or high‐grade Hodgkin’s and non‐Hodgkin’s tumours . Indeed, a case of SR of Hodgkin’s‐like lymphoma has been reported in a cat and in a horse…”

“…3,5 Among the lymphomas, SR has been reported mostly in patients with low-grade NHL, but some cases are reported among intermediate or high-grade Hodgkin's and non-Hodgkin's tumours. 7 Indeed, a case of SR of Hodgkin's-like lymphoma has been reported in a cat 8 and in a horse. 9 To the author's knowledge this is the first reported case of SR of non-feline leukaemia virus (FeLV)-related feline, high-grade NHL.…”