Hodgkin's disease in patients with antibodies to human immunodeficiency virus a study of 22 patients

Serrano, Manuel; Bellas, Carmen; Campo, Elı́as; Ribera, Josep‐Marǐa; Martín, Carmen; Rubio, Rafael; Moreno, Carmen; Ocaña, Inmaculada; Buzón, L; Yebra, Miguel; Font, Miguel Echemendía; Martı́nez, Miguel-Angel

doi:10.1002/1097-0142(19900515)65:10<2248::aid-cncr2820651015>3.0.co;2-w

Cited by 78 publications

(15 citation statements)

References 32 publications

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“…Following these inclusion criteria, 19 articles [1,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27] on HD and AIDS published in the English literature between 1988 and 1998 were the subject of our review. Seventeen articles [1,10,11,12,13,14,15,16,17,18,20,22,23,24,25,26,27], for a total of 532 patients, reported data on the histological distribution of HD in the setting of HIV infection, according to the Rye modifications of the classification of Lukes and Butler.…”

Section: Selection Of the Papersmentioning

confidence: 99%

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Rapezzi

Ugolini

Ferraris

et al. 2001

Annals of Hematology

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The relative incidence of Hodgkin's disease (HD) has been found to have increased approximately seven times in HIV-infected patients. We analyzed the histological distribution of HIV-associated HD with the aim of clarifying purported difference(s) from de novo HD. References on HIV/AIDS-associated HD were retrieved from the most complete databases. Nineteen articles were the subject of our analysis. Seventeen of them reported data on the histological type of HIV/AIDS-associated HD patients; the route of infection and age of the patients were also considered when available. According to the Peto's methodology, histological types were compared with those from two large studies in the United States on de novo HD: 3,245 cases from the Surveillance, Epidemiology, and End Results (SEER) and 1,140 from Stanford University. The analysis of the two groups showed statistically significant differences (p<0.001) in the percentage of all histological types and odds ratios (OR) of the pooled effect of 0.4 (95% CI: 0.3-0.6) for lymphocyte predominance (LP), 0.3 (95% CI: 0.2-0.4) for nodular sclerosis (NS), 3.2 (95% CI: 2.6-3.8) for mixed cellularity (MC), and 6.3 (95% CI: 4.5-8.8) for lymphocyte depletion (LD). Comparison with the Stanford University series yielded similar results. Whilst retrospective and based on a limited number of cases, our data confirm a higher incidence of unfavorable histological subtypes in HIV-infected patients and show a reduction in the observed cases of good prognosis subtypes. Prospective studies, with careful histological observations, are required to better evaluate the characteristics of the LP subtype in the special setting of HIV infection.

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Section: Selection Of the Papersmentioning

confidence: 99%

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Rapezzi

Ugolini

Ferraris

et al. 2001

Annals of Hematology

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“…The median age of our patients is more advanced than the one reported in HIV-associated HL cases (35 years versus 29 to 31 years, respectively; 11, 12). Moreover, peripheral blood cytopenia is found in all six patients, whereas this feature seems to occur less frequently in HIV-related HL patients with bone marrow involvement (7 3 ; 11, 13, 14). Finally, median survival of our IBM-HIV-HL patients was very short (4 mo), compared with usual HIV-HL Italian population (15 mo) or when the analysis was restricted to Italian HIV-HL patients with CD4 count of Ͻ200 cells/mm 3 (11 months; 12).…”

Section: Discussionmentioning

confidence: 82%

“…The occurrence of Hodgkin lymphoma (HL; 1) in human immunodeficiency virus (HIV)-infected individuals is a well-known phenomenon (2), although its inclusion in acquired immunodeficiency syndrome (AIDS)-defining illnesses is still a matter of debate (3,4). In contrast to the case of HL unrelated to HIV infection, HL in HIV patients most often shows an altered natural history (5) and is characterized by disseminated disease, with bone marrow involvement being a relatively common feature (6,7). The bone marrow may be the primary manifestation of disease, although a subsequent nodal biopsy usually shows tumor localization, even in the absence of obvious lymphadenopathy or organomegaly (8).…”

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confidence: 99%

Isolated Bone Marrow Manifestation of HIV-Associated Hodgkin Lymphoma

et al. 2002

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Human immunodeficiency virus-associated Hodgkin lymphoma frequently involves the bone marrow and is usually recognized at staging after Hodgkin lymphoma diagnosis on a lymph node or other tissue biopsies, but occasionally the marrow involvement is the only apparent manifestation of disease. In the latter setting, diagnosis can be problematic. From a total of 42 patients with newly diagnosed human immunodeficiency virus-associated Hodgkin lymphoma, 22 subjects had positive marrow involvement at diagnosis; 16 of them had additional substantial histological and/or clinical extramedullary Hodgkin lymphoma. In the remaining 6 patients the bone marrow was the only site of disease at diagnosis. In all six cases, bone marrow biopsy revealed obvious lymphomatous involvement. Reed-Sternberg cells were identified both morphologically and immunophenotypically in all cases. Spared marrow tissue consistently showed fibrosis. All patients were males with a median age of 35 years (range, 31-58 years). All presented with fever, blood cytopenias, and severe CD4؉ lymphocyte depletion (median, 70 cells/mm 3 ). After diagnosis, all staging procedures were negative, and all patients were treated with chemotherapy. Median survival was 4 months (range, 2-118 mo). Longer survival was achieved in the patients who completed chemotherapy regimens; three subjects, however, died shortly before the full completion of chemotherapy, two of them from Hodgkin lymphoma. Isolated bone marrow HIV-associated Hodgkin lymphoma may be an underestimated condition in HIV-infected patients; in those individuals with unexplained fever and blood cytopenias, bone marrow biopsy should be performed with the aim of assessing for Hodgkin lymphoma, even in the absence of nodal and visceral lymphomatous involvement. A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy.

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“…Histological examination is essential for diagnosis and staging. Prognosis is poor, with mean survival time of less than one year, despite treatment with multi-drug chemotherapy 3,24 .…”

Section: Non-hodgkin's Lymphoma (Nhl)mentioning

confidence: 99%

Oral Cavity: A Mirror to Hiv Manifestations

Grover¹,

Bhardwaj²,

Gupta³

2013

Int. Res. J. Pharm.

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A multitude of oral lesions have been described in individuals infected with the human immunodeficiency virus. Human immunodeficiency virus infection is a major interest and concern to dentists and other health care workers because of the many varieties of oral lesions often associated with Human immunodeficiency virus infection. Individual's tested seropositive for Human immunodeficiency virus infections are more susceptible to occurrence of lesions in oral cavity. This review covers the clinical and therapeutics aspects of Human immunodeficiency virus associated oral diseases. Data was collected from detailed search through research and review articles of scientific journals and magazines as well as through Pubmed and National medical library database.

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Hodgkin's disease in patients with antibodies to human immunodeficiency virus a study of 22 patients

Cited by 78 publications

References 32 publications

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Isolated Bone Marrow Manifestation of HIV-Associated Hodgkin Lymphoma

Oral Cavity: A Mirror to Hiv Manifestations

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