Histological subtypes of Hodgkin's disease in the setting of HIV infection

Rapezzi, Davide; Ugolini, Donatella; Ferraris, AM; Racchi, Omar; Gaetani, Gian Franco

doi:10.1007/s002770100294

Cited by 18 publications

(3 citation statements)

References 35 publications

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“…Whereas MCCHL and LDCHL were strongly associated with HIV infection, all NSCHL, the most commonly diagnosed HL type in Rwanda, were HIV negative. This is consistent with studies in high‐income settings,21, 22, 23 but is the first formal report from sub‐Saharan Africa.…”

Section: Discussionsupporting

confidence: 91%

A case–control study of HIV infection and cancer in the era of antiretroviral therapy in Rwanda

Mpunga

Znaor

Uwizeye³

et al. 2018

Intl Journal of Cancer

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The aim of this study was to assess the association between HIV infection and cancer risk in Rwanda approximately a decade after the introduction of antiretroviral therapy (cART). All persons seeking cancer care at Butaro Cancer Center of Excellence (BCCOE) in Rwanda from 2012 to 2016 were routinely screened for HIV, prior to being confirmed with or without cancer (cases and controls, respectively). Cases were coded according to ICD‐O‐3 and converted to ICD10. Associations between individual cancer types and HIV were estimated using adjusted unconditional logistic regression. 2,656 cases and 1,196 controls differed by gender (80.3% vs. 70.8% female), age (mean 45.5 vs. 37.7 years), place of residence and proportion of diagnoses made by histopathology (87.5% vs. 67.4%). After adjustment for these variables, HIV was significantly associated with Kaposi Sarcoma (n = 60; OR = 110.3, 95%CI 46.8–259.6), non‐Hodgkin lymphoma (NHL) (n = 265; OR = 2.5, 1.4–4.6), Hodgkin lymphoma (HL) (n = 76; OR = 5.2, 2.3–11.6) and cancers of the cervix (n = 560; OR = 5.9, 3.8–9.2), vulva (n = 23; OR = 17.8, 6.3–50.1), penis (n = 29; OR = 8.3, 2.5–27.4) and eye (n = 17; OR = 4.7, 1.0–25.0). Associations varied by NHL/HL subtype, with that for NHL being limited to DLBCL (n = 56; OR = 6.6, 3.1–14.1), particularly plasmablastic lymphoma (n = 6, OR = 106, 12.1–921). No significant associations were seen with other commonly diagnosed cancers, including female breast cancer (n = 559), head and neck (n = 116) and colorectal cancer (n = 106). In conclusion, in the era of cART in Rwanda, HIV is associated with increased risk of a range of infection‐related cancers, and accounts for an important fraction of cancers presenting to a referral hospital.

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Section: Discussionsupporting

confidence: 91%

A case–control study of HIV infection and cancer in the era of antiretroviral therapy in Rwanda

Mpunga

Znaor

Uwizeye³

et al. 2018

Intl Journal of Cancer

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“…Similar proportions of death due to HIV were observed in these subgroups. These results are consistent with many prior studies that have shown mixed cellularity and lymphocyte-depleted HL to be more common among HIV-infected individuals, and have shown the risk of these subtypes is particularly high (5, 9, 23, 24). These subtypes are also known to have the strongest association with EBV (25).…”

Section: Discussionsupporting

confidence: 92%

Prevalence of HIV Infection among U.S. Hodgkin Lymphoma Cases

Shiels

Koritzinsky

Clarke

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Hodgkin Lymphoma (HL) is uncommon in the U.S. general population; however, HL risk is elevated in people with human immunodeficiency virus (HIV) infection. Thus, despite the low HIV prevalence in the U.S, the HIV epidemic may have contributed substantially to the general population burden of HL. Methods We used data from 14 U.S. cancer registries in the Surveillance, Epidemiology and End Results Program that recorded HIV status of HL cases at diagnosis during 2000–2010. We computed the HIV prevalence in HL cases by demographic and tumor characteristics, the proportion of deaths among HL cases due to HIV, and 5-year mortality by HIV status. Results Of 22,355 HL cases, 848 (3.79%) were HIV-infected at diagnosis. HIV prevalence in HL cases was greater among males than females (6.0 vs. 1.2%). Among males, HIV prevalence was greatest among 40–59 year-olds (14.2%), non-Hispanic blacks (16.9%), Hispanics (9.9%) and among cases of lymphocyte-depleted (15.1%) and mixed cellularity HL (10.5%). Eight percent of male and 1.5% of female HL cases died from HIV. Five-year mortality was two-fold higher in HIV-infected HL cases (36.9 vs. 17.5%). Conclusions In the U.S., a substantial proportion of lymphocyte-depleted and mixed cellularity HL cases and HL cases among non-Hispanic black, Hispanic and middle-aged men are HIV-infected. Additionally, HIV is an important cause of death among HL cases. Impact Clinicians should be aware of the high prevalence of HIV in certain subgroups of HL patients and routine HIV testing should be recommended for all patients presenting with HL.

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“…Coinfection with EBV occurs in 90–100% of cases, compared to 30–40% in HIV-negative patients) [ 172 ]. In HIV-related cHL, mixed cellularity is the most common subtype, followed by lymphocyte depletion and nodular sclerosis [ 29 , 35 , 173 ].…”

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

Verdu-Bou

Tapia

Hernández-Rodríguez

et al. 2021

Cancers

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The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein–Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed.

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Histological subtypes of Hodgkin's disease in the setting of HIV infection

Cited by 18 publications

References 35 publications

A case–control study of HIV infection and cancer in the era of antiretroviral therapy in Rwanda

A case–control study of HIV infection and cancer in the era of antiretroviral therapy in Rwanda

Prevalence of HIV Infection among U.S. Hodgkin Lymphoma Cases

Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

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