Hodgkin's disease in association with human immunodeficiency virus infection. Pathologic and immunologic features

Pelstring, Richard J.; Zellmer, Richard B.; Sulak, Laura E.; Banks, Peter M.; Clare, Nanette

doi:10.1002/1097-0142(19910401)67:7<1865::aid-cncr2820670709>3.0.co;2-f

Cited by 40 publications

(10 citation statements)

References 43 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We confirmed previous findings of a severely altered microenvironment in HIV-associated Hodgkin lymphoma with decreased CD4 numbers in the tissue. [6][7][8][9] Although previous studies observed an inverted CD4/CD8 T-cell ratio, we showed that this is merely due to decreased CD4 numbers, whereas the absolute number of CD8 þ T-cells was stable in HIV-positive and HIV-negative cases. Interestingly, this study showed significantly increased numbers of CD163 þ macrophages in HIV-related Hodgkin lymphoma, whereas the numbers of S100 þ dendritic cells and Hodgkin-and Reed-Sternberg cells were similar between HIV-positive and HIV-negative cases.…”

Section: Discussioncontrasting

confidence: 67%

“…5 As HIV infection usually involves decreased CD4 þ T-cell counts in the peripheral blood, several studies have addressed the issue of the microenvironment in HIV-associated Hodgkin lymphoma and have found the CD4/CD8 T-cell ratio to be inverted. [6][7][8][9] However, the number of cases examined was very small in the majority of the studies 6,8,9 (o10 HIV-positive classical Hodgkin lymphoma cases each). Thompson et al 7 analyzed 47 HIV-positive Hodgkin lymphoma cases and found a 'sarcomatoid' pattern of the reactive microenvironment to be significantly associated with an adverse clinical outcome.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma

et al. 2013

View full text Add to dashboard Cite

Combination antiretroviral therapy is highly effective in HIV infection, leading to decreased incidences of AIDSdefining neoplasms. However, HIV patients still have a 10-fold increased risk of developing classical Hodgkin lymphoma compared with the general population. As Hodgkin-and Reed-Sternberg cells represent only a minority in the tumor infiltrate, the aim of the present study was to characterize the microenvironment of HIV-related classical Hodgkin lymphoma and compare it with classical Hodgkin lymphoma cases of immunocompetent individuals. The major morphologic differences were the presence of necrotic foci and the absence of epithelioid cell formation in HIV-related Hodgkin lymphoma. We observed a significantly decreased number of CD4 þ T-cells and a significantly increased number of CD163 þ macrophages in HIVrelated Hodgkin lymphoma. Cases exhibiting a 'sarcomatoid' pattern of the reactive infiltrate exhibited significantly greater numbers of macrophages, associating the 'sarcomatoid' pattern to the presence of spindle-shaped macrophages. Whereas, rosetting of CD4 þ T-cells around Hodgkin-and Reed-Sternberg cells was frequently observed in classical Hodgkin lymphoma in immunocompetent persons; rosetting in a subset of HIV-related Hodgkin lymphoma cases appeared to involve cytoplasmic protrusions of spindle-shaped macrophages. HIV-related Hodgkin lymphoma, therefore, is characterized by unique morphologic features, which should be recognized by pathologists.

show abstract

Section: Discussioncontrasting

confidence: 67%

mentioning

confidence: 99%

Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Following these inclusion criteria, 19 articles [1,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27] on HD and AIDS published in the English literature between 1988 and 1998 were the subject of our review. Seventeen articles [1,10,11,12,13,14,15,16,17,18,20,22,23,24,25,26,27], for a total of 532 patients, reported data on the histological distribution of HD in the setting of HIV infection, according to the Rye modifications of the classification of Lukes and Butler.…”

Section: Selection Of the Papersmentioning

confidence: 93%

“…Seventeen articles [1,10,11,12,13,14,15,16,17,18,20,22,23,24,25,26,27], for a total of 532 patients, reported data on the histological distribution of HD in the setting of HIV infection, according to the Rye modifications of the classification of Lukes and Butler. We assumed that the Lukes and Butler classification was a valid instrument to provide as much uniformity as possible to retrospective histological data from the literature.…”

Section: Selection Of the Papersmentioning

confidence: 98%

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Rapezzi

Ugolini

Ferraris

et al. 2001

Annals of Hematology

View full text Add to dashboard Cite

The relative incidence of Hodgkin's disease (HD) has been found to have increased approximately seven times in HIV-infected patients. We analyzed the histological distribution of HIV-associated HD with the aim of clarifying purported difference(s) from de novo HD. References on HIV/AIDS-associated HD were retrieved from the most complete databases. Nineteen articles were the subject of our analysis. Seventeen of them reported data on the histological type of HIV/AIDS-associated HD patients; the route of infection and age of the patients were also considered when available. According to the Peto's methodology, histological types were compared with those from two large studies in the United States on de novo HD: 3,245 cases from the Surveillance, Epidemiology, and End Results (SEER) and 1,140 from Stanford University. The analysis of the two groups showed statistically significant differences (p<0.001) in the percentage of all histological types and odds ratios (OR) of the pooled effect of 0.4 (95% CI: 0.3-0.6) for lymphocyte predominance (LP), 0.3 (95% CI: 0.2-0.4) for nodular sclerosis (NS), 3.2 (95% CI: 2.6-3.8) for mixed cellularity (MC), and 6.3 (95% CI: 4.5-8.8) for lymphocyte depletion (LD). Comparison with the Stanford University series yielded similar results. Whilst retrospective and based on a limited number of cases, our data confirm a higher incidence of unfavorable histological subtypes in HIV-infected patients and show a reduction in the observed cases of good prognosis subtypes. Prospective studies, with careful histological observations, are required to better evaluate the characteristics of the LP subtype in the special setting of HIV infection.

show abstract

“…In addition, single cases from small series showing features potentially similar to IBM-HIV-HL as defined in the present study have been reported (17,18), although selection criteria were not clearly specified. All cases hereby reported were diagnosed on the basis of detection of classical ReedSternberg cells with typical immunophenotype in the bone marrow; furthermore, strict selection criteria for isolated bone marrow involvement were adopted, and the single patient (Case 2) who, despite the lack of clinically evident lymphadenopathy, underwent a lymph node biopsy failed to show nodal HL.…”

Section: Discussionmentioning

confidence: 99%

Isolated Bone Marrow Manifestation of HIV-Associated Hodgkin Lymphoma

et al. 2002

View full text Add to dashboard Cite

Human immunodeficiency virus-associated Hodgkin lymphoma frequently involves the bone marrow and is usually recognized at staging after Hodgkin lymphoma diagnosis on a lymph node or other tissue biopsies, but occasionally the marrow involvement is the only apparent manifestation of disease. In the latter setting, diagnosis can be problematic. From a total of 42 patients with newly diagnosed human immunodeficiency virus-associated Hodgkin lymphoma, 22 subjects had positive marrow involvement at diagnosis; 16 of them had additional substantial histological and/or clinical extramedullary Hodgkin lymphoma. In the remaining 6 patients the bone marrow was the only site of disease at diagnosis. In all six cases, bone marrow biopsy revealed obvious lymphomatous involvement. Reed-Sternberg cells were identified both morphologically and immunophenotypically in all cases. Spared marrow tissue consistently showed fibrosis. All patients were males with a median age of 35 years (range, 31-58 years). All presented with fever, blood cytopenias, and severe CD4؉ lymphocyte depletion (median, 70 cells/mm 3 ). After diagnosis, all staging procedures were negative, and all patients were treated with chemotherapy. Median survival was 4 months (range, 2-118 mo). Longer survival was achieved in the patients who completed chemotherapy regimens; three subjects, however, died shortly before the full completion of chemotherapy, two of them from Hodgkin lymphoma. Isolated bone marrow HIV-associated Hodgkin lymphoma may be an underestimated condition in HIV-infected patients; in those individuals with unexplained fever and blood cytopenias, bone marrow biopsy should be performed with the aim of assessing for Hodgkin lymphoma, even in the absence of nodal and visceral lymphomatous involvement. A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy.

show abstract

Hodgkin's disease in association with human immunodeficiency virus infection. Pathologic and immunologic features

Cited by 40 publications

References 43 publications

Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma

Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma

Histological subtypes of Hodgkin's disease in the setting of HIV infection

Isolated Bone Marrow Manifestation of HIV-Associated Hodgkin Lymphoma

Contact Info

Product

Resources

About