HLA-G coding region and 3′untranslated region (3′UTR) in two Chinese Han populations

Wang, Wen Yi; Tian, Wei; Liu, Xue Xiang; Li, Lixin

doi:10.1016/j.imlet.2016.05.017

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…The HLA-E and HLA-G alleles exhibit limited polymorphisms, with only ten 4-digit HLA-E alleles and twenty-two 4-digit HLA-G alleles (IMGT/HLA, http://www.ebi.ac.uk/ipd/ imgt/hla/, Release 3.36.0, 2019 April). In this study, the distributions of HLA-E and HLA-G alleles in the control group are similar to those in the normal Chinese Han population (Table 4) (21,24,29).…”

Section: Discussionsupporting

confidence: 76%

The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

Huang

Chen

et al. 2019

Ann Transl Med

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Background: The polymorphisms of classical HLA-Ia and HLA-II loci have been associated with Posner-Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical HLA-Ib (e.g., HLA-E and HLA-G) loci with PSS have not been reported for in the southern Chinese population. This study aimed to evaluate the associations of the HLA-E and HLA-G loci with PSS in a southern Chinese Han population group. Methods: Ninety-seven unrelated patients with PSS and 90 ethnically matched control subjects were recruited from the Shenzhen Eye Hospital in China. The full-length sequences of HLA-E and HLA-G genes were amplified by long-range high-fidelity PCR, and the third exon of the HLA-E gene and the coding region of the HLA-G gene were sequenced.

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Section: Discussionsupporting

confidence: 76%

The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

Huang

Chen

et al. 2019

Ann Transl Med

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“…Not only 5' URR and 3' UTR are important, also the amino acid differences in the alpha2 domain have been found to influence the peptide binding repertoire resulting in functional differences between different HLA-G subtypes (234). Typing to identify the HLA-G alleles has mainly been performed in the framework of population and evolutionary studies and studies on reproduction, infection and disease associations, often limited to sequencing of exons 2-4 (230,235,236), sometimes combined with identification of the 14 bp insertion/deletion in the 3' UTR region (237)(238)(239). Recently, also NGS has been used to identify the HLA-G alleles present (212,215,(240)(241)(242).…”

Section: Non-classical Hla Class I Determinationmentioning

confidence: 99%

HLA Class I Molecules as Immune Checkpoints for NK Cell Alloreactivity and Anti-Viral Immunity in Kidney Transplantation

et al. 2021

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Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines upon activation. NK cells also contribute to the allo-immune response upon kidney transplantation either by promoting allograft rejection through lysis of cells of the transplanted organ or by promoting alloreactive T cells. In addition, they protect against viral infections upon transplantation which may be especially relevant in patients receiving high dose immune suppression. NK cell activation is tightly regulated through the integrated balance of signaling via inhibitory- and activating receptors. HLA class I molecules are critical regulators of NK cell activation through the interaction with inhibitory- as well as activating NK cell receptors, hence, HLA molecules act as critical immune checkpoints for NK cells. In the current review, we evaluate how NK cell alloreactivity and anti-viral immunity are regulated by NK cell receptors belonging to the KIR family and interacting with classical HLA class I molecules, or by NKG2A/C and LILRB1/KIR2DL4 engaging non-classical HLA-E or -G. In addition, we provide an overview of the methods to determine genetic variation in these receptors and their HLA ligands.

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Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: Implications for HLA-G transcriptional control and for case-control association studies

et al. 2018

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HLA-G coding region and 3′untranslated region (3′UTR) in two Chinese Han populations

Cited by 3 publications

References 33 publications

The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

HLA Class I Molecules as Immune Checkpoints for NK Cell Alloreactivity and Anti-Viral Immunity in Kidney Transplantation

Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: Implications for HLA-G transcriptional control and for case-control association studies

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HLA-G coding region and 3′untranslated region (3′UTR) in two Chinese Han populations

Cited by 3 publications

References 33 publications

The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

HLA Class I Molecules as Immune Checkpoints for NK Cell Alloreactivity and Anti-Viral Immunity in Kidney Transplantation

Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: Implications for HLA-G transcriptional control and for case-control association studies

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Product

Resources

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The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

The genetic contribution of HLA-E01:03 and HLA-E01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese