HLA‐DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases

Helenius, L. Miia J.; Hallikainen, Dorrit; Helenius, Ilkka; Meurman, Jukka H.; Koskimies, S.; Tervahartiala, Pekka; Kivisaari, Leena; Hietanen, Jarkko; Suuronen, Riitta; Lindqvist, Christer; Leirisalo‐Repo, Marjatta

doi:10.1080/03009740310004603

Cited by 21 publications

(15 citation statements)

References 23 publications

(19 reference statements)

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“…Two studies have been conducted to analyze the associations of HLA types with temporomandibular dysfunction (TMD). In patients with rheumatic diseases together with TMD and in patients with severe TMD several HLA-A, -B and -DR alleles have been found in increased frequency [27] [30]. In this study, subjective TMD symptoms, mouth opening and ‘clicking’ as a sign of TMD were recorded.…”

Section: Discussionmentioning

confidence: 96%

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

et al. 2014

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Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail. This prospective cross-sectional study examined associations of HLA-A, -B and -DRB1 types with common oral diseases in a healthy Swiss adult population. 257 subjects (107 m, 150 f, mean age: 43.5 yr; range: 21–58 yr) with known HLA-A, -B and -DRB1 profiles and comprehensive medical records were included. A thorough anamnesis was followed by oral examinations including saliva flow measurements, the DMFT score for cariological status, complete periodontal status with plaque and bleeding indexes as well as assessment of mucosal alterations and temporomandibular dysfunction (TMD). Student’s t-test and Pearson chi-square test were utilized to compare the oral diseases between HLA positive and negative subjects. Bonferroni correction for multiple comparisons was used and PBonf<0.05 was considered statistically significant. HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with less periodontal disease manifestations. HLA-A32 had a positive association with TMD dysfunction (PBonf = 0.012). No other statistically significant associations were observed. In conclusion, HLA types may contribute to the development of oral diseases in generally healthy Caucasian adults.

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Section: Discussionmentioning

confidence: 96%

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

et al. 2014

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“…According to another study, Koeppe and colleagues [23] reported that treatment of FM patients with the 5-HT 3 receptor antagonist tropisetron reduced rCBF in the contralateral primary somatosensory (SI), posterior insula, and ACC. Their result is also consistent with our findings of a reduced fMRI signal evoked in the insula, thalamus and precuneus (somatosensory association cortex).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effectiveness of Pregabalin in Alleviating Pain Associated with Fibromyalgia: Using Functional Magnetic Resonance Imaging Study

Kim

Lee

et al. 2013

PLoS ONE

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PurposeTo assess the efficacy of pregabalin by showing differences in the neuronal activities of fibromyalgia (FM) patients before and after longitudinal treatment using functional magnetic resonance imaging (fMRI).Materials and MethodsIn total, 21 female patients with FM and 11 age- and gender-matched healthy controls participated. FM patients underwent fMRI at baseline and following pharmacological therapy with pregabalin to diminish their pain. Pressure-pain stimuli were delivered on the subject’s thumbnail bed during fMRI scans. Brain activation regions in fMRI were evaluated for longitudinal changes using a paired t-test. Changes in clinical features were also assessed with the Fibromyalgia Impact Questionnaire (FIQ), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), Widespread Pain Index (WPI), Symptom Severity Scale Score (SSS), and State-Trait Anxiety Inventory (STAI).ResultsClinical scores were reduced significantly following therapy with five of the six clinical tests (FIQ, BFI, BDI, WPI, SSS; p < 0.05). Brain activation post-treatment was significantly lower than that pre-treatment in 13 regions of the brain (p < 0.001).ConclusionsOur findings confirm that pregabalin influences aspects of the whole pain matrix, using fMRI, inducing longitudinal changes in neuronal activity during the pain state, and that it reduces pain and other core symptoms of FM. This method could be applied to other longitudinal clinical trials of pharmacological treatments for FM.

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“…Initial studies on immune‐related markers explored the possibility of human leukocyte antigens (HLA) (major histocompatibility complex) being associated to TMD with inconclusive results (59). In patients with various rheumatic diseases, HLA antigens were associated with TMD (60, 61). More recently, immune‐inflammatory response genes became a matter of interest.…”

Section: Candidate Genes For Temporomandibular Joint Disordermentioning

confidence: 99%