The many faces of the genetics contribution to temporomandibular joint disorder

Abstract

Most of the studies on genetic variation contributing to TMD are approaching the disease mainly from an immune-inflammatory perspective. Recent investigations of the genetic variables which may predict identifiable levels of pain perception may uncover new approaches to our traditional treatment modalities for the chronic pain patient.

Temporomandibular Disorders in German and Chinese Adolescents

“…Gegenwärtig richtet sich daher ein stärkerer Fokus auf biologische (d.h. hormonelle oder genetische) Faktoren als Ursache für die Entstehung von CMD [6,31,36,42]. Naturgemäß wirken diese allgemein auf den gesamten Organismus und haben quasi nur mittelbar Auswirkungen auf das Kausystem.…”

“…Hence there is currently stronger focus on biological (i.e. hormonal or genetic) factors as the cause of TMD [6,31,36,42]. They naturally have a general effect on the entire body -their impact is only indirect, as it were, on the masticatory system.…”

Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction

“…[112][113][114][115] The exact etiology of TMJD is largely unknown due to the number of suspected causes and their multifactorial nature. Symptoms of TMJD range from mild pain and clicking of the joint to chronic, intractable pain and limited jaw motion.…”

The Role of Electromyography in Temporomandibular Joint Diseases

“…Tüm bu problemlerin tan›s›n›n koyulmas›nda ve ayr›c› tan›s›n›n yap›l-mas›nda; anamnez, fizik muayene, radyoloji ve biyokimya ile elektromyografiyi (EMG) içine alan laboratuvar tetkikleri yard›mc› olmaktad›r (10). Bu yard›mc› tetikler içerisinde bulunan EMG özellikle kaslar›n-sinirlerin çal›flmas›n› muayene etmede ve bu bölgelere ait ay›r›c› tan›da en etkili yöntemlerdendir (8).…”