HLA Cw*06 is not essential for streptococcal-induced psoriasis

Fry, Lionel; Powles, A.V.; Corcoran, Sean; Rogers, Sarah; Ward, Jennifer; Unsworth, D J

doi:10.1111/j.1365-2133.2005.07101.x

Cited by 20 publications

(24 citation statements)

References 24 publications

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“…Note in this context that we selected M protein and keratin peptides that were predicted to bind relatively strongly with HLACw*0602, which is carried by ,50% of patients with chronic psoriasis (27), although this may vary between populations (28,29). Second, we selected for this study patients who reported aggravation of their disease in association with sore throat, which only applies to ∼40% of patients with chronic psoriasis in Iceland (R.H. Thorleifsdottir, J.H.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Thorleifsdottir

Sigurðardóttir

Sigurgeirsson

et al. 2012

The Journal of Immunology

105

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Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients’ blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasis. Twenty-nine patients with chronic psoriasis and history of exacerbation after sore throat were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and monitored for 2 y clinically and by enumeration of circulating skin homing T cells that respond to short homologous M protein or keratin peptides. Thirteen patients (86%) showed sustained improvement after tonsillectomy ranging from 30 to 90% reduction in disease severity. Furthermore, there was a close correlation between the degree of clinical improvement in individual patients and reduction in the frequency of peptide-reactive skin-homing T cells in their circulation. No corresponding clinical or immunologic changes were observed among the controls. These findings indicate that tonsillectomy may have a beneficial effect on chronic psoriasis because the palatine tonsils generate effector T cells that recognize keratin determinants in the skin.

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Section: Discussionmentioning

confidence: 99%

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Thorleifsdottir

Sigurðardóttir

Sigurgeirsson

et al. 2012

The Journal of Immunology

105

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“…Aber auch akut-exanthematische Schübe einer chronischen Plaquepsoriasis werden vornehmlich durch Streptokokkeninfektionen getriggert [54], und Patienten mit chronischer Plaquepsoriasis zeigen eine höhere Inzidenz streptogener Pharyngitiden oder Kolonisierung [17]. Dabei ist v. a. die HLA-Cw6-assoziierte Typ-1-Psoriasis mit frühem Erkrankungsbeginn und positiver Psoriasisfamilienanamnese mit Streptokokkeninfektionen assoziiert, während diese für Typ-2-Psoriasis (spä-ter Erkrankungsbeginn, negative Familienanamnese, kein HLA-Cw6) keine oder kaum eine Rolle spielen [15,60].…”

Section: Tab 1 Häufigkeit Von Streptokokkeninfektionen Bei Psoriasisunclassified

Bedeutung von Streptokokken für die Psoriasispathogenese

Prinz

2009

Hautarzt

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Infections with Streptococcus pyogenes are highly relevant among the environmental factors that contribute to first onset or relapses of psoriasis in predisposed individuals. Streptococcal angina or pharyngitis, but also perianal streptococcal dermatitis, vulvovaginitis or balanoposthitis are potential causes. Several mechanisms such as molecular mimicry or superantigens may be involved. Many patients develop a chronic streptococcal infection or colonization that may result from the ability of streptococci for intracellular uptake and persistence in epithelial cells. Whether and under what conditions a curative treatment of streptococcal infection by tonsillectomy or antibiotic treatment may affect the course of psoriasis, as proposed by several observations, needs to be determined in more detail by clinical trials.

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“…A number of clinical reports suggest that bacterial infection can trigger psoriasis, and it has been known for a long time that acute exacerbation of psoriasis may follow streptococcal infection [18,19,20,21]. The resulting psoriasis is commonly of the guttate pattern, but existing plaque psoriasis may also be exacerbated [3, 21].…”

Section: Discussionmentioning

confidence: 99%

“…The resulting psoriasis is commonly of the guttate pattern, but existing plaque psoriasis may also be exacerbated [3, 21]. …”

Section: Discussionmentioning

confidence: 99%

Medical History, Drug Exposure and the Risk of Psoriasis

et al. 2008

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Background/Aims: To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Methods: Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. Results: The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5–1.3) in hypertensive subjects, 1.1 (95% CI 0.6–2.0) in diabetics and 1.1 (95% CI 0.7–1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1–0.8). Conclusion: Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.

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HLA Cw*06 is not essential for streptococcal-induced psoriasis

Abstract: Thus, not all patients with streptococcal-related psoriasis carry Cw06. The role of Cw06 in psoriasis, if any, has yet to be determined.

Cited by 20 publications

References 24 publications

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Bedeutung von Streptokokken für die Psoriasispathogenese

Medical History, Drug Exposure and the Risk of Psoriasis

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HLA Cw*06 is not essential for streptococcal-induced psoriasis

Abstract: Thus, not all patients with streptococcal-related psoriasis carry Cw*06. The role of Cw*06 in psoriasis, if any, has yet to be determined.

Cited by 20 publications

References 24 publications

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

Bedeutung von Streptokokken für die Psoriasispathogenese

Medical History, Drug Exposure and the Risk of Psoriasis

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Product

Resources

About

Abstract: Thus, not all patients with streptococcal-related psoriasis carry Cw06. The role of Cw06 in psoriasis, if any, has yet to be determined.