Bedeutung von Streptokokken für die Psoriasispathogenese

Prinz, Jörg C.

doi:10.1007/s00105-008-1661-5

Cited by 19 publications

(5 citation statements)

References 61 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in Streptococcaceae has been observed in psoriatic subject, confirming data of previous works, in which the presence of Streptococcus spp was linked to the pathogenesis of psoriasis [ 20 , 21 ]. Streptococcaceae are highly relevant among the environmental factors that are involved in the development of psoriasis [ 21 ]. Different mechanisms, such as molecular mimicry, superantigens and the ability of streptococci for intracellular uptake and persistence in skin cells, may be involved in the pathogenesis of the disease.…”

Section: Discussionsupporting

confidence: 89%

Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

Drago

Grandi

et al. 2016

Clin Mol Allergy

View full text Add to dashboard Cite

Background Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria in worsening the symptomatology of AD and psoriasis. In the present study we evaluated the skin microbiota composition in accurately selected subjects affected by (AD) and psoriasis.Methods Three first cousins were chosen for the study according to strict selection of criteria. One subject was affected by moderate AD, one had psoriasis and the last one was included as healthy control. Two lesional skin samples and two non-lesional skin samples (for AD and psoriatic subjects) from an area of 2 cm2 behind the left ear were withdrawn by mean of a curette. For the healthy control, two skin samples from an area of 2 cm2 behind the left ear were withdrawn by mean of a curette. DNA was extracted and sequencing was completed on the Ion Torrent PGM platform. Culturing of Staphylococcus aureus from skin samples was also performed.ResultsThe psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance. Moreover, an increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject, if compared with AD individual and control. Finally, AD individual showed a larger abundance of S. aureus than psoriatic and healthy subjects. Moreover, the microbiota composition of non-lesional skin samples belonging to AD and psoriatic individuals was very similar to the bacterial composition of skin sample belonging to the healthy control.ConclusionSignificant differences between the skin microbiota of psoriatic individual and healthy and AD subjects were observed.

show abstract

Section: Discussionsupporting

confidence: 89%

Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

Drago

Grandi

et al. 2016

Clin Mol Allergy

View full text Add to dashboard Cite

show abstract

“…E. coli has been reported as one of the related microorganisms that may cause psoriasis [ 51 ]. Streptococcus is a well-recognized reason for acute guttate psoriasis [ 52 ], which is highly correlated with first onset/relapse in individuals who are prone to psoriasis [ 53 ]. So some scholars believe that long-term prevention and treatment of Streptococcus pyogenes infection are very important in the management of chronic plaque psoriasis [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

RETRACTED: Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel

Zhu

Xie

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Psoriasis is a long-lasting and recurrent autoimmune disease which is incurable so far. Dead Sea water (DSW) therapy is an effective approach to help control the symptoms of psoriasis due to the abundant mineral ions in DSW, which inspired the material formulation in this study. Rubidium–Sodium alginate/Polyacrylamide hydrogels (Rb-SA/PAAm gels) composed of sodium alginate and polyacrylamide interpenetrating network structure with different concentrations of rubidium and certain magnesium and zinc content were prepared for the treatment of psoriasis. The obtained results suggest the good mechanical properties of the Rb-SA/PAAm gels including toughness and swelling performance. In terms of in vitro tests, the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line (Hacats) but also inhibits the activity against inflammatory NF-κβ signaling pathway. Meanwhile, they can release Rb + which enable the Rb-SA/PAAm gels have better antibacterial ability to Streptococcus and Escherichia coli. The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod (IMQ) in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen. In conclusion, the 100Rb-SA/PAAm gel has demonstrated great potential to be a topical wettable dressing for psoriasis treatment.

show abstract

“…tempered skin inflammation with lymphocytes leaving the skin (15-17); impaired adhesion molecule expression [e.g. CLA-counterligand E-selectin) on skin microvasculature (18,19); relapsing patients: IFN-alphamediated disease relapse with skin-infiltrating lymphocytes (20)(21)(22)(23), provoking role of underlying infections (24)(25)(26)(27)(28)]. We recommend further investigations to find clear elucidation for our observations and confirm our primary results establishing a potential role of CLA in predicting long-term effectiveness of TNFalpha inhibitor therapy in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous lymphocyte‐associated antigen as a novel predictive marker of TNF‐alpha inhibitor biological therapy in psoriasis

Jókai

Szakonyi

Kontár

et al. 2013

Experimental Dermatology

View full text Add to dashboard Cite

system and IL-13, IL-17E/IL-25 as well as COX-2 might be key factors to aggravate Ag-induced AD-like symptoms. AcknowledgementsThis study was supported by a grant from the Korean Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A091121). Author contributionsJi-Yun Kim performed the research, designed the research study, analysed the data and wrote the paper; Mi Sook Jeong performed the research and analysed the data; Kui Young Park designed the research study and analysed the data; Seong Jun Seo designed the research study, analysed the data and wrote the paper. Ethics approval for animal careAll experiments with mice were performed in accordance with the regulations and the approval of the Institutional Animal Care and Use Committee of Chung-Ang University (Approval No. 10-1011) and Korea Conformity Laboratories (KCL). Conflict of interestsThe authors have declared no conflicting interests. Supporting InformationAdditional Supporting Information may be found in the online version of this article: Data S1. Supplementary Materials and Methods. Figure S1. Effects of FA inhalation on the clinical skin severity score and the infiltration of inflammatory cells in ear skin of NC/Nga mice. Table S1. Effect of FA inhalation on the production of total levels of immunoglobulin (Ig) isotypes in plasma. Table S2. Effect of FA inhalation on the protein expressions of cytokines in splenocytes. Abstract: A considerable number of patients with psoriasis show secondary resistance during long-term TNF-alpha inhibitor therapy, necessitating the identification of reliable predictive markers. Predictive role of cutaneous lymphocyte-associated antigen (CLA) was investigated. Thirty-eight severe patients with psoriasis were treated for a 24-week-long study period. Clinical responsiveness (PASI) and changes in flow cytometry-measured peripheral lymphocyte CLA expression (week 0-2-6) were statistically analysed. Regarding 24-week-long treatment outcome patients were divided into two groups: During the first 6 weeks, mean CLA expression showed significant (P = 0.034604) increase among responders (32/38), while after a preliminary increase, it was significantly (P = 0.012539) decreasing in the relapsing group (6/38). Pearson's correlation analysis showed significant negative correlation between PASI and CLA changes. Responders showed (not significantly) lower initial CLA expression than relapsing patients. Our observations suggest change in CLA expression during the first 6 weeks of induction period to serve as a potential predictive marker of TNF-alpha inhibitor therapy in psoriasis.

show abstract

Bedeutung von Streptokokken für die Psoriasispathogenese

Cited by 19 publications

References 61 publications

Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

Skin microbiota of first cousins affected by psoriasis and atopic dermatitis

RETRACTED: Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel

Cutaneous lymphocyte‐associated antigen as a novel predictive marker of TNF‐alpha inhibitor biological therapy in psoriasis

Contact Info

Product

Resources

About