The high rate of psoriasis patients with NRRs, especially among women, less educated and elderly patients, indicates a content validity problem of the measure. A reconsideration of the use of the DLQI for medical and financial decision-making in psoriasis patients is suggested.

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11 Background There is a growing interest in policy making 12 for using utility measures and identifying algorithms to 13 convert disease-specific measures into utilities. 14 Objectives To analyse the relationship between EQ-5D, 15 Dermatology Life Quality Index (DLQI) and Psoriasis 16 Area and Severity Index (PASI) in psoriasis. To transform 17 DLQI scores, and key clinical, demographic and health 18 service utilisation variables into utilities. 19 Methods A cross-sectional questionnaire survey of 200 20 consecutive adult patients with moderate to severe psoria-21 sis was carried out in two Hungarian university clinics. The 22 relationship between the outcome measures were analysed 23 with correlations and with the known-groups method. 24 Bivariate and multivariate regression algorithms on EQ-5D 25 scores were formulated. 26Results The mean age of respondents was 51 years 27 (SD = 12.9), 68.5 % were male, and 51.5 % received 28 biological therapy. Median EQ-5D, DLQI, and PASI scores 29 were 0.73, 3.0, and 3.45, respectively. EQ-5D showed a 30 moderate correlation with the DLQI and with the PASI 31 (r s = -0.48 and -0.43, p \ 0.05). Strong correlation was 32 found between DLQI and PASI (r s = 0.81, p \ 0.05). 33 DLQI and PASI discriminated better among groups cate-34 gorised by the localisation of the lesions than EQ-5D.

The spectrum of the clinical manifestation and the course of folliculotropic mycosis fungoides are broad and differ from classic mycosis fungoides. Folliculotropic neoplastic T-cell proliferation is associated with activation of inflammatory reactive T- and B-lymphoid cells, mesenchymal cells and changes in the hair follicle.

T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cellmediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases.