RETRACTED: Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel

Abstract

Psoriasis is a long-lasting and recurrent autoimmune disease which is incurable so far. Dead Sea water (DSW) therapy is an effective approach to help control the symptoms of psoriasis due to the abundant mineral ions in DSW, which inspired the material formulation in this study. Rubidium–Sodium alginate/Polyacrylamide hydrogels (Rb-SA/PAAm gels) composed of sodium alginate and polyacrylamide interpenetrating network structure with different concentrations of rubidium and certain magnesium and zinc content were prepared for the treatment of psoriasis. The obtained results suggest the good mechanical properties of the Rb-SA/PAAm gels including toughness and swelling performance. In terms of in vitro tests, the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line (Hacats) but also inhibits the activity against inflammatory NF-κβ signaling pathway. Meanwhile, they can release Rb + which enable the Rb-SA/PAAm gels have better antibacterial ability to Streptococcus and Escherichia coli. The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod (IMQ) in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen. In conclusion, the 100Rb-SA/PAAm gel has demonstrated great potential to be a topical wettable dressing for psoriasis treatment.

Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases

“…Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor which activates by inflammatory cytokines or growth factors and then translocates to the nucleus, where it is involved in the regulation of DNA transcription ( Yu et al, 2009 ). Stat3 has become a research hotspot because of its essential function during diverse biological processes such as proliferation, differentiation, anti-apoptosis, inflammatory response, and angiogenesis ( Cheng et al, 2020 ; Tian et al, 2020 ; He et al, 2021 ). In previous researches, Stat3 was considered as a critical signaling molecule for immune escape, atherosclerosis, malignancy and cardiac injury ( Huynh et al, 2017 ; Chen et al, 2019 ; Comita et al, 2021 ; Zhang et al, 2022 ).…”

Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment

“…Inflammatory mediators including IL-17A, IL-1β, and TNF-α, play important roles in the occurrence and development of psoriatic inflammation and excessive proliferation of keratinocytes. − Consistently, our results showed the mRNA expression of the proinflammatory cytokines IL-17A, IL-1β, and TNF-α were dramatically increased in the psoriatic skin but were downregulated in all QT-treatment groups, and the inhibitory effect of HPCD/QT Lipo@gel was superior to the other QT formulations (Figure E–G). HPCD/QT Lipo@gel treatment also efficiently inhibited over-reactive immune responses (Figure B,C), which could be represented by the reduced spleen index . It was noteworthy that although DEX treatment had a high therapeutic potency, it also induced substantial side effects.…”

“…HPCD/QT Lipo@gel treatment also efficiently inhibited over-reactive immune responses (Figure 5B,C), which could be represented by the reduced spleen index. 57 It was noteworthy that although DEX treatment had a high therapeutic potency, it also induced substantial side effects. For example, DEX resulted in a weight loss of 12.8% compared to the control group (Figure 5D).…”

In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy

“…Then, CRT, HSP-70 and HSP-90 on the surface of dying cells activate the “eat-me” of APCs [ 74 ]. As a topical immune response modifier against malignant skin tumors in clinical practice [ 75 ], Imiquimod (R837) is incorporated in various types of hydrogels to control the scarring process [ 76 ], treat skin diseases [ 77 ] and cure malignant tumors [ 78 ]. Therefore, to strengthen the immune response and ICD induced by the Dox/hydrogel delivery system, we added the immune adjuvant R837 into the delivery system.…”