HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine

Yao, Yufeng; Yang, Huijuan; Shi, Lei; Liu, Shuyuan; Li, Chuanying; Chen, Jun; Zhou, Ziyun; Sun, Mingzhe; Shi, Li

doi:10.3389/fimmu.2019.00428

Cited by 15 publications

(21 citation statements)

References 39 publications

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“…In this way, we observed two particularly interesting immune genes (HLA-DPB1 and IL6) that contained multiple DMPs differing between high and low vaccine responders. Hypomethylation of HLA-DPB1 as found in high compared with low vaccine responders may indeed strengthen the overall immune response as previously demonstrated by the contribution of HLA to cellular host immunity in response to anthrax vaccine adsorbed [33]; rubella vaccine [34]; hepatitis B vaccine; and the inactivated Japanese encephalitis vaccine [35]. Additional evidence connecting HLA genotype and expression to vaccine immune responses was found in measles seropositive and seronegative individuals [36].…”

Section: Discussionsupporting

confidence: 60%

Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination

et al. 2021

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Background Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests a key role for epigenetics in the maturation and regulation of the immune system in health and disease. The study aimed to investigate epigenetic changes in early life and to understand the relationship between the epigenome and antigen-specific antibody responses to pneumococcal vaccination. Methods The epigenetic profiles from 24 healthy children were analyzed at 12 months prior to a booster dose of the 13-valent pneumococcal conjugate vaccine (PCV-13), and at 24 months of age, using the Illumina Methylation 450 K assay and assessed for differences over time and between high and low vaccine responders. Results Our analysis revealed 721 significantly differentially methylated positions between 12 and 24 months (FDR < 0.01), with significant enrichment in pathways involved in the regulation of cell–cell adhesion and T cell activation. Comparing high and low vaccine responders, we identified differentially methylated CpG sites (P value < 0.01) associated with HLA-DPB1 and IL6. Conclusion These data imply that epigenetic changes that occur during early childhood may be associated with antigen-specific antibody responses to pneumococcal vaccines.

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Section: Discussionsupporting

confidence: 60%

Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination

et al. 2021

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“…As Japanese encephalitis vaccine be considered, our previous study investigated the association of HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by the inactivated Japanese encephalitis vaccine (IJEV) and showed that HLA-DQB1 * 02:01 was significantly associated with JEV seropositivity (P < .05), while HLA-DQB1 * 02:02 was significantly associated with JEV seronegativity (P < .05). 14 In addition, we found that certain HLA-DRB1 and HLA-DPB1 alleles were associated with higher geometric mean titers (GMTs) than others. 14 The association study of cytokine gene variations with vaccine antibody response are particularly important in developing countries where JE is still a major health issue, because it may provide a clue for vaccine efficacy evaluation and new vaccine development.…”

Section: Introductionmentioning

confidence: 87%

“…14 In addition, we found that certain HLA-DRB1 and HLA-DPB1 alleles were associated with higher geometric mean titers (GMTs) than others. 14 The association study of cytokine gene variations with vaccine antibody response are particularly important in developing countries where JE is still a major health issue, because it may provide a clue for vaccine efficacy evaluation and new vaccine development.…”

Section: Introductionmentioning

confidence: 87%

“…JEV-specific NAbs were determined by the National Institute for Food and Drug Control using the 50% plaque-reduction neutralization test according to the requirement of the Pharmacopoeia of the People's Republic of China 17 as previously reported. 14 As the NAbs at 50% plaque-reduction neutralization titer (PRNT50) of at least 10 have been established as a correlate of protection against development of JE disease in humans, 3 PRNT50 <10 or a PRNT50 increased less than fourfold after vaccination indicated negative seroconversion, while PRNT50 > 10 or a PRNT50 with at least a fourfold increase after vaccination indicated positive seroconversion.…”

Section: Japanese Encephalitis Vaccine Neutralization Antibody Detectionmentioning

confidence: 99%

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Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the TNF-α, IL-2, IL-4 and IL-10 genes with the antibody response to inactivated Japanese encephalitis vaccine

Yao

et al. 2020

Human Vaccines & Immunotherapeutics

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To investigate whether the TNF-α, IL-2, IL-4 and IL-10 genes contribute to variations in vaccine-induced immune responses after immunization with the inactivated Japanese encephalitis vaccine (IJEV), a total of 369 individuals who received the IJEV were enrolled. Based on Japanese encephalitis virus (JEV) neutralization antibodies (NAbs), the individuals were divided into seropositive (SP) and seronegative (SN) groups. Then, 17 SNPs in the TNF-α, IL-2, IL-4 and IL-10 genes were genotyped using the TaqMan method. Although there was no association of the TNF-α, IL-2, IL-4 and IL-10 genes with JEV seropositivity triggered by JEV vaccination when all the individuals in the SP and SN groups were compared, differences were observed in a subgroup analysis. In the male group, rs2243291 in the IL-4 gene showed a difference between the JEV SP and SN groups with the overdominant model (P = .045), and the C/G genotypes conferred more JEV seropositivity (OR = 1.87; 95% CI: 1.01-3.49); the CT genotype of rs3093726 in the TNF-α gene showed higher JEV NAbs geometric mean titer (GMT) than the TT genotype (P = .018, CT: 1.677 ± 0.144 vs TT: 1.271 ± 0.039). Furthermore, the rs1800629 genotype in the TNF-α gene and the rs1800896 genotype in the IL-10 gene exhibited a trend of association with JEV seropositivity in the female group, but the difference was not significant. The present study suggested that the polymorphisms in the cytokine genes could be associated with sex-specific JEV NAbs seroconversion. However, more samples should be studied, and further functional verification should be performed.

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“…Molecular genetic variations exert distinct influences on antigenspecific immune responses (29,32). The role of HLA genes as regulators of immune responses may also depend on the nature of the immune responses induced by different antigens (38,39). However, the identification of causal variants within the HLA region is intrinsically difficult due to the complex polymorphisms found in this region.…”

Section: The Role Of Hla Molecules As Immune Response Genes and The mentioning

confidence: 99%

Personalized Human Papillomavirus Vaccination for Persistence of Immunity for Cervical Cancer Prevention: A Critical Review With Experts' Opinions

2020

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The development of cervical cancer has been shown to involve both viral and host factors. The host factors are those that determine the specific response to human papillomavirus (HPV) infection by the patient's immune system. The immune responses to vaccines have been shown to be influenced by polymorphisms in genes involved in innate and adaptive immunity. The specific genetic variants that may influence the immune responses to HPV vaccine which may contribute to persistence of immunity (POI) have not been widely studied yet. In order to address the question as to "is it right to vaccinate all children, and all with equal dose?" we have critically examined the knowledge of common immunogenetic and immunogenomic variations that may influence the HPV vaccine POI across various populations. We have also identified a number of specific research questions that need to be addressed in future research into host molecular genetic variations and HPV vaccine POI in order to afford life-long protection against the development of cervical cancer. This work informs future insights for improved HPV vaccine designs based on common host molecular genetic variations.

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HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine

Cited by 15 publications

References 39 publications

Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination

Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination

Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the TNF-α, IL-2, IL-4 and IL-10 genes with the antibody response to inactivated Japanese encephalitis vaccine

Personalized Human Papillomavirus Vaccination for Persistence of Immunity for Cervical Cancer Prevention: A Critical Review With Experts' Opinions

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