Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the
            <i>TNF-α, IL-2, IL-4</i>
            and
            <i>IL-10</i>
            genes with the antibody response to inactivated Japanese encephalitis vaccine

Yao, Yufeng; Xu, Xiaofei; Li, Yaheng; Wang, Xiaona; Yang, Huijuan; Liu, Shuyuan; Deng, Yan; Zhao, Zhihui; Yin, Qiongzhou; Sun, Mingzhe; Shi, Li

doi:10.1080/21645515.2020.1724743

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…As a result, genome-wide association studies (GWAS) and other genetic investigations have focused on large panels of genes, including genetic variants of HLA, PAMPs, cytokines, chemokines, and receptor molecules, as possible causes of variability in the response to antiviral vaccines against hepatitis B, measles, rubella, influenza A, smallpox, anthrax, and mumps [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Similar results were obtained studying the association of antiviral vaccine response with polymorphic variants in cytokine genes, such as TNF-α, IL-2, IL-4 IL-10, IL-28, IFNγ [ 13 , 14 , 15 , 16 ].…”

Section: Introductionsupporting

confidence: 75%

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

et al. 2023

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The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotypes of IL-1R1 rs2234650 or the GG homozygous genotype of IL-6 rs1800795 SNP. T-positive genotypes are also significantly more common in subjects with higher titers at day 105. In addition, in this group of subjects, the frequency of the CT genotype of IL-4 rs2243250 is higher among those vaccinated with higher titers. Moreover, these SNPs and TNFA rs1800629 are differently distributed in a group of subjects that were found infected by SARS-CoV-2 at day 105 of evaluation. Finally, subjects that were found to be infected by SARS-CoV-2 at day 105 were significantly older than the uninfected subjects. Taken together, these data seem to suggest that age and polymorphisms of key cytokines, which regulate inflammation and humoral immune response, might influence the magnitude of the antibody response to vaccination with BNT162B2, prompting speculation about the possible benefit of a genetic background-based assessment of a personalized approach to the anti-COVID vaccination schedule.

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Section: Introductionsupporting

confidence: 75%

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

et al. 2023

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“…Moreover, PPARG rs17793951 AG + GG genotype was associated with a higher risk of low responsiveness to influenza vaccine in males and females, but this effect was significant only in females. An article also reported gender difference in the association of genetic polymorphisms with immune response to Japanese encephalitis vaccine (Yao et al, 2020). We speculated that some immune-suppressive behaviors more commonly in men may mask the correlation of genotypes with response to influenza vaccine, such as smoking (Godoy et al, 2018).…”

Section: Discussionmentioning

confidence: 91%

Association of Single Nucleotide Polymorphisms in LEP, LEPR, and PPARG With Humoral Immune Response to Influenza Vaccine

Wei

Zhong

et al. 2021

Front. Genet.

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Background: Although previous studies have proposed leptin plays an important role in energy metabolism as well as in immune response, the effects of leptin-related genes on influenza vaccine-induced immune response remain unexplored. In this study, we aimed to investigate the potential association of leptin gene (LEP), leptin receptor gene (LEPR), and peroxisome proliferator activated receptor gamma gene (PPARG) polymorphisms with humoral immune response to influenza vaccine.Methods: Based on the seroconversion to influenza vaccine, 227 low-responders and 365 responders were selected in this study, and 11 candidate single nucleotide polymorphisms (SNPs) were genotyped using the MassARRAY technology platform. Univariate and multivariate logistic regression analyses were used to explore the association of SNPs in LEP, LEPR, and PPARG with humoral immune response to influenza vaccine. We also conducted a stratified analysis by gender to further clarify this association. The haplotypes analysis was performed using SNPStats.Results: Significant differences were observed in the genotypic distribution of PPARG rs17793951 between the two groups (p = 0.001), and the PPARG rs17793951 AG + GG genotype was associated with a higher risk of low responsiveness to influenza vaccine adjusted for gender and age (additive genetic model: OR = 2.94, 95% CI = 1.67–5.19, dominant genetic model: OR = 2.81, 95% CI = 1.61–4.92). No significant association of other SNPs in LEP and LEPR with immune response to influenza vaccine was found. The stratified analysis found the gender difference in the association of LEPR and PPARG variants with immune response to influenza vaccine. We found that LEPR rs6673591 GA + AA genotype was correlated with low responsiveness to influenza vaccine only in males (OR = 1.96, 95% CI = 1.05–3.67), and PPARG rs17793951 AG + GG genotype was associated with low responsiveness to influenza vaccine in females (OR = 3.28, 95% CI = 1.61–6.67). Compared with the CGGAGGC haplotype composed of LEPR rs1327118, rs7602, rs1137101, rs1938489, rs6673591, rs1137100, and rs13306523, the CAAAAAC haplotype was positively correlated with immune response of influenza vaccine (OR = 0.34, 95% CI = 0.15–0.77). Haplotype TG comprised of PPARG rs796313 and rs17793951 was associated with a 2.85-fold increased risk of low responsiveness to influenza vaccine.Conclusion: Our study identified that PPARG rs17793951 variants were significantly associated with the immune response to influenza vaccine.

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“…In 12 studies, there were neither qualitative reports of cytokine levels nor were there quantitative data of cytokine concentrations; therefore, they did not meet our inclusion criteria [ 41 , 48 , 56 , 58 , 60 , 62 , 70 , 77 , 87 , 88 , 91 , 92 ]. Two studies measured the efficacy and side effects of vaccines [ 43 , 96 ]. The full-text article could not be found in 21 studies (_((((xxx))))_)[ 80 , 104 – 123 ].…”

Section: Resultsmentioning

confidence: 99%

Cytokines and chemokines profile in encephalitis patients: A meta-analysis

et al. 2022

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Background Encephalitis is caused by autoimmune or infectious agents marked by brain inflammation. Investigations have reported altered concentrations of the cytokines in encephalitis. This study was conducted to determine the relationship between encephalitis and alterations of cytokine levels in cerebrospinal fluid (CSF) and serum. Methods We found possibly suitable studies by searching PubMed, Embase, Scopus, and Web of Science, systematically from inception to August 2021. 23 articles were included in the meta-analysis. To investigate sources of heterogeneity, subgroup analysis and sensitivity analysis were conducted. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42021289298. Results A total of 23 met our eligibility criteria to be included in the meta-analysis. A total of 12 cytokines were included in the meta-analysis of CSF concentration. Moreover, 5 cytokines were also included in the serum/plasma concentration meta-analysis. According to the analyses, patients with encephalitis had higher CSF amounts of IL-6, IL-8, IL-10, CXCL10, and TNF-α than healthy controls. The alteration in the concentration of IL-2, IL-4, IL-17, CCL2, CXCL9, CXCL13, and IFN-γ was not significant. In addition, the serum/plasma levels of the TNF-α were increased in encephalitis patients, but serum/plasma concentration of the IL-6, IL-10, CXCL10, and CXCL13 remained unchanged. Conclusions This meta-analysis provides evidence for higher CSF concentrations of IL-6, IL-8, IL-10, CXCL10, and TNF-α in encephalitis patients compared to controls. The diagnostic and prognostic value of these cytokines and chemokines should be investigated in future studies.

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Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the TNF-α, IL-2, IL-4 and IL-10 genes with the antibody response to inactivated Japanese encephalitis vaccine

Cited by 11 publications

References 40 publications

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

Association of Single Nucleotide Polymorphisms in LEP, LEPR, and PPARG With Humoral Immune Response to Influenza Vaccine

Cytokines and chemokines profile in encephalitis patients: A meta-analysis

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