HLA and Disease Associations in Iraq

Jabbar, A.

doi:10.1155/1993/192019

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…A comprehensive Medline search was conducted and no data was found concerning the prevalence of CD among the adult Bedouin population. There are only few known research investigations regarding CD in Arabic populations, and those were primarily interested in children [ 3 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of the Celiac Disease Among Urban Bedouin Population in Israel

Inna

Andrew

Hanna

et al. 2012

Gastroenterology Research

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BackgroundCeliac disease (CD) is a common, but often under-diagnosed condition with possible serious complications. CD, having a prevalence of about 1% is more common than once thought. Only limited research is available comparing differences between adults and children. A comprehensive Medline search was conducted. No data was found concerning the prevalence of CD among the adult Bedouin population.MethodsThe research is retrospective and descriptive. The objective of our research was to determine the prevalence of the CD within adult and child Bedouin populations in urban Israel. A report of all of diagnosed CD patients extracted from the medical computerized information system (“Clicks”).ResultsIn our sample we found the prevalence was 0.51% in children and 0.12% in adults.ConclusionIn our opinion, one of reasons for the low prevalence level in the Bedouin community might be that typical CD symptoms are less prominent in Bedouin communities than in other communities. But no doubt hypo-diagnosis does exist. We suppose more advanced research about the nature and typical clinical manifestations of CD within the Bedouin population need to be investigated. Medical personnel working within the Bedouin community needs information concerning CD and the characteristics of diagnosis and treatment in the Bedouin community. The Bedouin community itself needs more information concerning CD and the importance of treatment, which could also improve early diagnosis and compliance.

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Section: Introductionmentioning

confidence: 99%

The Prevalence of the Celiac Disease Among Urban Bedouin Population in Israel

Inna

Andrew

Hanna

et al. 2012

Gastroenterology Research

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“…Thus, early detection of atrophic gastritis and gastric cancer can be done using multiple markers like HLA-DR, HLA-DQ, age, sex and H pylori infection (17). Other studies done in Iraq showed that there is an association between HLA and different diseases in Iraq (18) like DR3 and DR4 is common in Insulin dependent diabetes mellitus (19,20), Inflammatory bowel disease was associated with DR8 (21). In conclusion, our results, together with other studies , support that genetic constitution through HLA-DR locus determines the mechanism and pathogenesis of disease as well as clinical and pathologic outcomes, triggered by the interaction between environmental factors and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

HLA-DRB103 And DRB115 Frequency In Helicobacter Pylori Superficial Gastritis

Salih¹

2019

Al-Kindy Col. Med. J

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Background: Background: Helicobacter pylori is an important gastrointestinal bacteria related to the development of superficial atrophic gastritis, peptic ulcer and gastric cancer. Human leukocyte antigens (HLA) may play an important roles in host immune responses to H pylori antigens. Aim of the study: to investigate the association between HLA-DRB1 genotypes and superficial gastritis with H. pylori infection in an Iraqi patients. Patients and methods: Sixty patients with superficial gastritis and 100 individuals with apparently normal results after endoscopic examination were recruited from Al-Kindy Teaching Hospital - Gastrocolonoscope Unit between January 2014 and July 2016. All study patients and controls group underwent upper gastrointestinal endoscopic examinations. They were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori and HLA Class II genotyping (HLA-DRB1). Results: Patients with superficial gastritis with H pylori. The infection showed significant expression (P=0.0001) DRB1*03:01 genotypes and DRB1*15:01 (P= 0.004) as compared to control group. Conclusions: Genetic factor may play a role in gastritis. HLA-DRB1*03 and HLA-DRB1*15 may increased the susceptibility to superficial gastritis in H pylori infected patients.

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