HLA-DRB1*03 And DRB1*15 Frequency In Helicobacter Pylori Superficial Gastritis

Salih, Wafaa Hazim

doi:10.47723/kcmj.v13i2.97

Cited by 1 publication

(1 citation statement)

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“…This may result fromthe central role of helper T cell (Th)1-mediated autoimmune responses in MS pathogenesis and the dominance of regulatory responses in favor of Th2 profile in H. pylori infection. On the other hand, several HLA alleles, such as DRB1*15 and DQB1*06 contribute to an increased risk of both H. pylori infection and MS [17][18][19][20] . We designed this crosssectional study to explore the distributions of HLA-DRB1 and HLA-DQB1 allele families and haplotypes in a group of Iranian MS patients with gastrointestinal manifestations related to H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and disease severity in multiple sclerosis patients: Is there a link with HLA alleles?

Mazaheri

Heshmati

Vazifehdaryazd

et al. 2022

MRAJ

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Backgrounds: Environmental factors such as bacterial infections, as well as genetic factors—in particular the human leukocyte antigen (HLA) alleles—have been implicated in the etiology of multiple sclerosis (MS). This study aims to explore the relationship between Helicobacter pylori infection, HLA alleles, and disease severity in Iranian MS patients. Methods: The study population comprised 125 MS patients and 153 ethnically matched healthy controls. Stool antigen test was used to detect H. pylori, and the expanded disability status scale (EDSS) scores were assessed in the patients. HLA-DRB1 and DQB1 alleles and haplotypes were determined in both the patients and the controls. The relationships between H pylori infection, HLA alleles, and EDSS were also analyzed. Results: HLA-DRB1*15 and DQB1*06 alleles families and the DRB1*15~DQB1*06 haplotype were significantly more frequent in MS patients, whereas HLA-DRB1*14 and DRB1*14~DQB1*05 haplotype were less frequent. Of the 125 MS patients, 38 were diagnosed with active H. pylori infection. We found lower frequencies of HLA-DRB1*15 (P = .08) and DRB1*16 (P = .05) alleles and a higher frequency of DQB1*02 (P = .06) in the H. pylori-positive patients. HLA-DRB1*07 was more prevalent in patients with EDSS≤3.0 (P = .06). More severe MS cases (EDSS>3.0) were linked to H pylori positivity (P = .02), disease chronicity (P = .001), receiving non-steroidal anti-inflammatory drugs (P = .02), and female gender (P = .05). Conclusion: These preliminary findings suggest a link between H. pylori infection and the severity of MS H. pylori-positive patients regardless of the type of HLA carriage.

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Section: Introductionmentioning

confidence: 99%