HL‐A Antigens in Hodgkin's Disease and Other Lymphomas

Sybesma, J. P. H. B.; Borst-Eilers, E; Holtzer, J. D.; Moes, Mieke; Pielage, Els; Planque, B.A. de

doi:10.1111/j.1423-0410.1972.tb03974.x

Cited by 9 publications

(3 citation statements)

References 10 publications

(4 reference statements)

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“…Enhanced susceptibility has been suggested in certain haplotypes (Walford et al, 1970;Thorsby et ai, 1971) but this is also contested (Lawler et a2, 1971). A similar discrepancy is found in Hodgkin's disease where a positive correlation with HL-A 5 has been found (Amiel, 1967), and confirmed (Zervas et al, 1970), only to be questioned in a larger series (Sybesma et al, 1972). Several factors may account for these differences.…”

Section: Leukaemic Antigenssupporting

confidence: 51%

Leukaemic Antigens

Pegrum

1973

Br J Haematol

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Section: Leukaemic Antigenssupporting

confidence: 51%

Leukaemic Antigens

Pegrum

1973

Br J Haematol

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“…When the results of various investigations (showing apart a high HL-A5 or W5 frequency in several cases) are pooled together, no correlation between Hodgkin's disease and a high HL-A5 or W5 frequency appears [3]. In our series of patients with Hodgkin's disease, we previously found a normal HL-A5 frequency [24].…”

Section: Discussionmentioning

confidence: 59%

“…Persons with sufficient antibody formation are called 'responders', while patients without sufficient antibody formation are called 'non-responders'. Details on methods and sera used for HL-A typing have been published elsewhere [24].…”

Section: Methodsmentioning

confidence: 99%

Antibody Response in Hodgkin’s Disease and Other Lymphomas Related to HL-A Antigens, Immunoglobulin Levels and Therapy

Sybesma¹,

Holtzer²,

Borst-Eilers³

et al. 1973

Vox Sanguinis

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A group of 38 patients with lymphomas (29 with Hodkin’s disease and 9 with other lymphomas) and a control group of 27 healthy individuals were vaccinated with an influenza vaccine, containing influenza A Hong Kong virus. Eight patients (6 with Hodgkin’s disease and 2 with other lymphomas) did not respond with a fourfold raise in titre or greater as measured by haemagglutination inhibition assay. In the healthy control group, everyone showed an adequate antibody response. In the patients, incapacity of antibody formation was not associated with cytostatic therapy, treatment with prednisone or the combination of the two, but a correlation was found with radiation therapy during the ‘immunization period’. HL-A typing and determination of serum immunoglobulin levels were performed both in the patients and in the healthy controls. A significant difference in HL-A12 frequency was found between patients with adequate antibody response to influenza vaccination (HL-A12 frequency 13%) and those without demonstrable antibody formation (HL-A12 frequency 62%). No significant differences in serum immunoglobulin levels were noted between the patients and the control persons.

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