Leukaemic Antigens

Pegrum, G. D.

doi:10.1111/j.1365-2141.1973.tb05721.x

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…There is growing evidence of the presence of antigenic determinants on the surface of human leukemic cells which are undetectable on normal cells (Harris 1973, Pegrum 1973. These antigens can stimulate both a specific cell immediated immune response in uiuo (Herberman et al 1973) and a leukemia specific mixed lymphocyte response in uitro (Bach et al 1969, Fridman & Kourilsky 1969, Gutterman et al 1973.…”

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confidence: 99%

Normal Human Sera Cytotoxic to Cells of Human Acute Leukemia

1976

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Eight human sera from healthy individuals with no history of immunization with human transplantation antigens have demonstrated complement dependent cytotoxicity to cells of some patients with active acute leukemia. The antigen(s) detected by these sera are absent from normal and remission lymphocytes and appear most often in ALL patients with a high peripheral lymphoblast count. Some B and T lymphoblastoid cell lines carry the antigen(s) as evidenced by their ability to react with and absorb the antileukemia activity. The data support the existence of at least two overlapping specificities detected by these antileukemia sera. The leukemia antigen(s) show no strong correlation with any known HLA antigen. These observations provide evidence for a human leukemia blast associated antigen or set of antigens which may be immunogenic in man. Their relationship to normal HLA antigens of loci other than A, B or C is unknown.

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Normal Human Sera Cytotoxic to Cells of Human Acute Leukemia

1976

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“…In previous studies, we have shown that the challenge to normal lymphocytes by leukaemic cells will activate both these mechanisms [8,11], and since the response following mixed cell culture (MLC) appears to be greater than could be explained by dif ferences of HL-A antigens alone it may be viewed as indirect evidence of the presence of 'leukaemic antigens' [1,3,4,10,14]. Further evi dence for the presence of such antigens is the atypical response of leu kaemic cells when exposed to the alloantisera used in tissue typing stud ies [6].…”

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Stimulation and Reactivity of Leukaemic Cells in Acute Myeloid Leukaemia

Pegrum¹,

Evans²,

Middleton³

1974

Acta Haematol

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¹⁴C-thymidine incorporation and cytotoxicity to a target cell were used to assess response of peripheral blood leucocytes from patients during the course of acute myeloid leukaemia. Studies were made after mixed culture with allogeneic lymphocytes and stimulation by mitogens. The leukaemic cells were found to respond to both types of stimulus but, just prior to relapse, a fall in reactivity following mixed culture was observed whereas response to mitogens at this time was usually enhanced. The leukaemic leucocytes were found to provoke both marked cytotoxicity and significantly increased ¹⁴C-thyιmidine uptake in normal lymphocytes after mixed culture. The degree of reactivity provoked altered during the course of the disease.

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“…Μεταξύ τών ένοχοποιουμένων παραγόντων είναι μεταβολές στους όμοιοστατικούς μηχανισμούς τού άνθρωπου, (Foster et al, 1971, Mangalic καί Robinson 1972, Robinson et al, 1971, Robinson καί Pike, 1970, Rytomma, 1973, ενδοκρινικές μεταβολές, (Whitmire et al, 1972), ή πολύ συχνότερα ανοσοβιολογικοί μηχανισμοί (Fialkow, 1967, Bach et al, 1969, Gutterman et al, 1973, Pegrum, 1973, Powles et al, 1971).…”

Section: "αλλοι παράγοντες ένοχοποιούμενοι οτήν αιτιολογία τής λευ χαιμίαςunclassified

Η Επιδημιολογια Της Λευχαιμιας Εις Το Olmsted County - Minnesota Η.Π.Α

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Leukaemic Antigens

Cited by 9 publications

References 31 publications

Normal Human Sera Cytotoxic to Cells of Human Acute Leukemia

Normal Human Sera Cytotoxic to Cells of Human Acute Leukemia

Stimulation and Reactivity of Leukaemic Cells in Acute Myeloid Leukaemia

Η Επιδημιολογια Της Λευχαιμιας Εις Το Olmsted County - Minnesota Η.Π.Α

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