35 patients with Hodgkin’s disease, 13 patients with other lymphomas and
26 control subjects have been typed for 8 HL-A antigens.
The frequency of HL-A8 and HL-A7 was higher among the patients with Hodgkin’s
disease and other lymphomas than among control subjects. In contrast to findings reported
by others we did not find any difference in HL-A5 frequency between patients
with Hodgkin’s disease and control subjects.
A group of 38 patients with lymphomas (29 with Hodkin’s disease and 9 with other lymphomas) and a control group of 27 healthy individuals were vaccinated with an influenza vaccine, containing influenza A Hong Kong virus. Eight patients (6 with Hodgkin’s disease and 2 with other lymphomas) did not respond with a fourfold raise in titre or greater as measured by haemagglutination inhibition assay. In the healthy control group, everyone showed an adequate antibody response.
In the patients, incapacity of antibody formation was not associated with cytostatic therapy, treatment with prednisone or the combination of the two, but a correlation was found with radiation therapy during the ‘immunization period’.
HL-A typing and determination of serum immunoglobulin levels were performed both in the patients and in the healthy controls. A significant difference in HL-A12 frequency was found between patients with adequate antibody response to influenza vaccination (HL-A12 frequency 13%) and those without demonstrable antibody formation (HL-A12 frequency 62%). No significant differences in serum immunoglobulin levels were noted between the patients and the control persons.
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