HIV neuropathy in pre-HAART patients and it′s correlation with risk factors in Central India

Dubey, T. N.; Raghuvanshi, Somnath Singh; Sharma, Himanshu; Saxena, Rita

doi:10.4103/0028-3886.121912

Cited by 10 publications

(5 citation statements)

References 17 publications

(25 reference statements)

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“…In our study, there was no association between gender and PN and is similar to previous studies. [ 23 , 24 ] Likewise, we did not find an association with SSW-EMLA test in detecting PN in our study, although other studies have shown the incidence of HIV PN was associated with increased age. [ 4 ] This is likely related to the poor immunological status found in our patients as shown in lower CD4+ finding.…”

Section: Discussioncontrasting

confidence: 75%

Early detection of peripheral neuropathy using stimulated skin wrinkling test in human immunodeficiency virus infected patients

et al. 2018

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Peripheral neuropathy is a common condition of human immunodeficiency virus (HIV)-infected patients, which often remains undetected. We assessed the performance of stimulated skin wrinkling-eutectic mixture of local anesthetic (SSW-EMLA) test compared with brief peripheral neuropathy screening (BPNS) to detect HIV neuropathy.This is a cross-sectional study conducted in HIV-positive patients. A modified skin wrinkling grading was used to assess SSW-EMLA effect. BPNS-detectable neuropathy was assessed by a combination of neuropathy severity scoring scale (subjective) and objective method of sensory and tendon reflex examination. The SSW-EMLA test accuracy with reference to BPNS was assessed using sensitivity and specificity and predictive values.In a total of 99 HIV patients, 61.6% were males and the majority age group were between 30 and 40 years (52%). The neuropathy detection was SSW-EMLA test 36.4% versus BPNS 15.2% (P = .04). The sensitivity of SSW-EMLA test was 60.0% [95% confidence interval (95% CI) 34.5–81.7], specificity 67% (95% CI 63.3–3–71.7), and overall accuracy of 66.7% (95% CI 58.9–73.2).The SSW-EMLA test detected many more peripheral neuropathy cases than BPNS in HIV patients and has potential as an alternative test for screening for HIV neuropathy in resource-constraint hospitals in Indonesia.

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Section: Discussioncontrasting

confidence: 75%

Early detection of peripheral neuropathy using stimulated skin wrinkling test in human immunodeficiency virus infected patients

et al. 2018

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“…The participants in whom the ARV regimen was not changed were also likely to improve. This is possible because it is either that the PN was not severe, the PN had just started or it was not suspected to be augmented with a particular toxic ARV type (Dubey et al 2013).…”

Section: Discussionmentioning

confidence: 99%

The effects of a physiotherapist-led exercise intervention on peripheral neuropathy among people living with HIV on antiretroviral therapy in Kigali, Rwanda

Tumusiime

Stewart

Venter

et al. 2019

South African Journal of Physiotherapy

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BackgroundHIV-associated peripheral neuropathy (PN) is common in people living with HIV. Its management is mostly symptomatic utilising pharmacological approaches.ObjectivesThis study determined the effects of an exercise intervention on PN among Rwandan people living with HIV receiving antiretroviral therapy (ART).MethodsA 12-week single-blinded randomised controlled trial using the Brief Peripheral Neuropathy Screen (BPNS) as the assessment tool tested the effects of an exercise intervention on PN, followed by a 12-week non-intervention period. A total of 120 people with HIV- associated PN on ART were randomised to an exercise or no exercise group. Both groups continued receiving routine care. A bivariate analysis using Pearson’s chi-square test for significant differences in PN symptoms and signs, between groups, at baseline, after the 12 weeks intervention and 12 weeks post-intervention using generalised linear regression models to determine predictors of treatment outcomes was undertaken, utilising an intention-to-treat analysis (alpha p ≤ 0.05).ResultsAt 12 weeks, the intervention group compared to the control: neuropathic pain 70% versus 94% (p < 0.005), PN symptoms severity – mild and/or none in 85% versus 60% (p < 0.001) and radiation of PN symptoms reduced, 80% versus 37% (p < 0.001). There were no differences in PN signs at 12 weeks intervention and at 12 weeks post-intervention. Having changed the antiretroviral (ARV) and having developed PN symptoms after the start on ARVs predicted treatment improvement, while demographic factors did not predict any treatment outcome.ConclusionA physiotherapist-led exercise intervention improved PN symptoms, but with non-significant improvement in PN signs. Factors related to early diagnosis and treatment of PN were facilitators for the improvement of PN symptoms.Clinical implicationsPhysiotherapist-led exercises should be integrated into the routine management of people living with HIV on ART with PN symptoms.

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“…In an Indian study on 75 patients, 40% had clinical HIV-associated sensory neuropathy (HIV-SN). [ 49 ] HIV-SN considerably affects their quality of life. Symptomatic relief therapy is usually not satisfactory.…”

Section: N Europathy D Ue To I mentioning

confidence: 99%

“…[ 54 ] According to a Western study, two-thirds of HIV-SN is subclinical,[ 55 ] which was less common (around 16%) in Indian study. [ 49 ]…”

Section: N Europathy D Ue To I mentioning

confidence: 99%

Epidemiology of peripheral neuropathy: An Indian perspective

Trivedi

Pandit

Ganguly

et al. 2017

Ann Indian Acad Neurol

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HIV neuropathy in pre-HAART patients and it′s correlation with risk factors in Central India

Cited by 10 publications

References 17 publications

Early detection of peripheral neuropathy using stimulated skin wrinkling test in human immunodeficiency virus infected patients

Early detection of peripheral neuropathy using stimulated skin wrinkling test in human immunodeficiency virus infected patients

The effects of a physiotherapist-led exercise intervention on peripheral neuropathy among people living with HIV on antiretroviral therapy in Kigali, Rwanda

Epidemiology of peripheral neuropathy: An Indian perspective

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