History of the discovery of thinlayer chromatography

Shostenkot, Yu. V.; Georgievskii, V. P.; Levin, M. G.

doi:10.1007/bf02757859

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…They coated microscope slides with a suspension of various adsorbents (calcium, magnesium, and aluminum oxide), deposited one drop of the sample solution on this layer and added one drop of the solvent. The separated sample components appeared as concentric rings that fluoresced in various colors under a UV lamp, and from that reason one of their conclusions was described as follows: “ A spot chromatographic method of analysis was developed; this method consists in that the separation of substances into zones is observed in thin layers of adsorbents using a drop of the substance ” [25]. In 1947 T.I.…”

Section: History and Development Of Microfluidic Devicesmentioning

confidence: 99%

Microfluidic Paper-Based Analytical Devices (μPADs) and Micro Total Analysis Systems (μTAS): Development, Applications and Future Trends

2013

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Microfluidic paper-based analytical devices and micro total analysis systems are relatively new group of analytical tools, capable of analyzing complex biochemical samples containing macromolecules, proteins, nucleic acids, toxins, cells or pathogens. Within one analytical run, fluidic manipulations like transportation, sorting, mixing or separation are available. Recently, microfluidic devices are a subject of extensive research, mostly for fast and non-expensive biochemical analysis but also for screening of medical samples and forensic diagnostics. They are used for neurotransmitter detection, cancer diagnosis and treatment, cell and tissue culture growth and amplification, drug discovery and determination, detection and identification of microorganisms. This review summarizes development history, basic fabrication methods, applications and also future development trends for production of such devices.

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Section: History and Development Of Microfluidic Devicesmentioning

confidence: 99%

Microfluidic Paper-Based Analytical Devices (μPADs) and Micro Total Analysis Systems (μTAS): Development, Applications and Future Trends

2013

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“…His breakthrough work countered genetic fatalism by demonstrating that dietary changes and nutritional supplementation can treat human behavioral disorders of obscure etiology, including alcoholism and schizophrenia. The advent of paper and notably 2D thin layer chromatography (TLC) , further improved peak capacity for resolution of hundreds of “spots” from complex biofluids that were detected by their intrinsic UV absorbance and/or reaction with specific colorimetric reagents. , However, the low separation efficiency, poor automation, and lack of quantitative analyses limited the applicability of planar chromatography for routine metabolite profiling applications …”

Section: Introduction: Separation Principles For Metabolite Profilingmentioning

confidence: 99%