1986
DOI: 10.1590/s0037-86821986000200007
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Histopatologia da esquistossomose mansoni em fígado de Mus musculus infectado por amostras humanas de fase aguda e crônica da periferia de Belo Horizonte, Minas Gerais

Abstract: Exemplares de Biomphalaria glabrataforam infectados com miracídios obtidos de ovos de Schistosoma mansoni, encontrados em fezes de indivíduos de 7 a 18 anos, da região de Lagoa da Pampulha, Belo Horizonte, MG. Os pacientes de fase aguda se infectaram em uma primeira visita ao foco. Os da fase crônica eram moradores próximos aos focos. Para cada caso clínico, isolou-se a respectiva amostra do parasita. Foram infectados pela cauda 55 camundongos fêmeas com 70 ± 10 cercárias. Cortes histológicos de fígados, corad… Show more

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Cited by 5 publications
(8 citation statements)
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References 12 publications
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“…Our measurements of hepatic granulomas differed from those obtained by Carvalho et al (1986), Coelho et al (1989), and Domingo and Warren (1968), presumably due to factors such the immunological reaction of the host to different strains, number of cercariae used to infected mice, different dates of sacrifice, and differing method of measuring the granulomas. Andrade and Warren (1964) and Raso (2000) described granulomas as initially bulky, with intense cellularity (predominently macrophages, lymphocytes, and eosinophyls); later, the exudate decreases and is substituted by conjunctive tissue until the formation of a fibroid nodule.…”
Section: Discussioncontrasting
confidence: 90%
See 1 more Smart Citation
“…Our measurements of hepatic granulomas differed from those obtained by Carvalho et al (1986), Coelho et al (1989), and Domingo and Warren (1968), presumably due to factors such the immunological reaction of the host to different strains, number of cercariae used to infected mice, different dates of sacrifice, and differing method of measuring the granulomas. Andrade and Warren (1964) and Raso (2000) described granulomas as initially bulky, with intense cellularity (predominently macrophages, lymphocytes, and eosinophyls); later, the exudate decreases and is substituted by conjunctive tissue until the formation of a fibroid nodule.…”
Section: Discussioncontrasting
confidence: 90%
“…In work published by Carvalho et al (1986), the maximum weight of mice found in the study at ten weeks p.i. had decreased.…”
Section: Discussionmentioning
confidence: 89%
“…Macro and microscopic analysis revealed changes on the liver surface (whitish areas, fibrosis, and granulomas) similar to the results of experimental studies with Mus musculus (CARVALHO et al, 1986;AMARAL et al, 2017) and Mus spretus (PÉREZ DEL VILLAR et al, 2013). The liver is the most affected organ by the infection and presence of of S. mansoni eggs (SILVA-SOUZA & VASCONCELOS, 2005;LOPES et al, 2006;SILVA et al, 2012;PÉREZ DEL VILLAR et al, 2013).…”
Section: Introductionsupporting
confidence: 75%
“…Thus, the mesenteric vasodilatation of the abdominal viscera observed macroscopically in the present study can be related to circulatory system changes caused by this drug. With progression of the pathological process, modifications in the cell constitution and aspect of the granulomas occur, and they become more fibrous and concentric (Raso et al, 1978;Carvalho et al, 1986;Silva et al, 2000;Tristão et al, 2000). However, a slight worm reduction in infected mice after prolonged PTX treatment (8 weeks) has been reported (El-Lakkany & Nosseir, 2007).…”
Section: Discussionmentioning
confidence: 99%
“…Macrophages are the most common cells observed in chronic disease, and the eggs progressively acquire a growing fibrous component (Andrade & Warren, 1964;Carvalho et al, 1986;Silva et al, 2000;Tristão et al, 2000). Macrophages are the most common cells observed in chronic disease, and the eggs progressively acquire a growing fibrous component (Andrade & Warren, 1964;Carvalho et al, 1986;Silva et al, 2000;Tristão et al, 2000).…”
Section: Introductionmentioning
confidence: 99%