Histopathological study of lymph node biopsy

Vachhani, Anand B; Bhuva, Kaushik; Jasani, Jasmin; Tandon, Rakesh

doi:10.7439/ijbar.v4i11.537

Cited by 11 publications

(11 citation statements)

References 9 publications

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“…In our study predominant site of lymph node biopsy was cervical followed by axillary lymph nodes. This observation was consistent with most of the recent studies like OluEddo AN [9] , Saraswat A et al [10] and Vachhani A [11] .…”

Section: Discussionsupporting

confidence: 82%

“…In present study non-neoplastic lesions (80.0%) were much more common than neoplastic lesions (19.93%) and these results were consistent with Kamat GC et al (88.92%) [5] , Rahman Md A (70.2%) [8] Saraswat A et al (90.9%) [10] , Vacchani A et al (75%) [11] , and Rao MN et al (56%) [12] . Reactive lymphadenitis (52.87%) comprised of the predominant pattern in non-neoplastic lesions.…”

Section: Discussionsupporting

confidence: 82%

“…Majority of cases were seen in 51-60 years followed by 31-40years of age group. In comparision to various studies in the literature our findings were similar to findings of Vachhani A et al (23%) and Tiwari M et al (11%) [11,6].…”

Section: Discussionsupporting

confidence: 81%

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A Descriptive Study of Histopathological Patterns of Lymph Node Biopsies In A Tertiary Care Hospital

Damle

Suryawanshi²,

Dravid³

et al. 2017

APALM

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and included 331 cases of lymph node biopsies. Detailed clinical history like age, sex, site, presenting complaints and clinical diagnosis was noted. Relevant findings and investigations were recorded. The study was approved by institutional ethical committee.Eligibility criteria adopted in our study: 1) Inclusion criteria: all type of lymph node specimens and all age groups.2) Exclusion criteria: inadequate samples and poorly preserved tissue were excluded.All cases of lymph node biopsies were received in 10% formalin. The gross morphological features like size of node, shape, color, consistency, presence of necrosis and matting were noted and taken sections from each. The specimens were processed in automated tissue processor and 4-5 micron thick paraffin embedded sections were taken and stained by Haematoxylin and ABSTRACTBackground: Lymph node is affected by various types of lesions, both non-neoplastic (inflammatory) or neoplastic. Due to non-specific symptoms, the clinical diagnosis are usually delayed thus lymph node biopsy is mandatory to arrive at specific diagnosis for appropriate management.Objective: 1) To study the spectrum of lymph node pathology with clinical correlation. 2) To study the different histological patterns of lymph node lesions and classify them into major categories. Methods:The present study was a prospective observational type of study and included 331 patients who presented with lymph node enlargement in a tertiary care hospital over a period of 3 years from Jan 2013 to Dec 2015. Detailed clinical history was noted. The specimens were routinely processed and stained by Haematoxylin and eosin. Special stains along with immunohistochemistry were done whenever required.Result: A total of 331 lymph node biopsies were studied. Age distribution varied from 4 to 81 years with male to female ratio of 1:1.4. Non -neoplastic lesions comprised of maximum cases (80.06%) while neoplastic lesion were present in (19.93%) cases. Reactive lymphadenitis was the predominant non-neoplastic finding followed by granulomatous lymphadenitis. Neoplastic lesions were included 3.61% cases of lymphoma and 16.31% cases of metastatic lesions. Conclusion:Lymphadenopathy is not uncommon in our region so lymph node biopsy is an important tool for early diagnostic and prognostic purpose. Reactive lymphadenitis was the most common cause of lymphadenopathy followed by granulomatous lymphadenitis. Keywords

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

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A Descriptive Study of Histopathological Patterns of Lymph Node Biopsies In A Tertiary Care Hospital

Damle

Suryawanshi²,

Dravid³

et al. 2017

APALM

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“…This observation was consistent with most of the recent studies. [9][10][11] The most common benign cause of lymphadenopathy was 66.9% (87 cases), and these results were agreed with the previous results. 4,7,10,11 Chronic, non-specific lymphadenitis comprised 46.9% (61 cases) of the predominant pattern in non-neoplastic lesions.…”

Section: Discussionsupporting

confidence: 82%

Patterns of lymph node pathology using biopsy evaluation tool for lymphadenopathy: a retrospective descriptive study conducted at Al Hussein Medical City 2014–2016

Alali

2017

IMJ

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Objective The study was assumed to determine the histopathological spectrum of lymphadenopathic specimens and showed the age and gender variation of these lesion. Methods It was a descriptive retrospective study wherein 130 cases of lymph node biopsy reports of specimens from patients 3 months to 81 years at Al Hussein Medical City between 1 January 2014 and 31 December 2016 were studied. Results A total of 130 lymph node biopsies were received of which female 58.46% (76 cases) and male 41.53% (54 cases), a male to female ratio of 1:1.4 and the P value 0.011 with significance difference. The age range was from 3 months to 81 years. Most cases were seen in the age group of 21-30 years (25 cases 19.23%). The non-neoplastic lesions were more common comprising 66.9% (87 cases) included 46.9% (61 cases) of chronic nonspecific lymphadenitis, tuberculosis lymphadenitis 18.46% (24 cases) and other lesions 1.5%, while the neoplastic lesions 33.07% (43 cases) included non-Hodgkin lymphoma 13.07% (17 cases), Hodgkin lymphoma 12.30% (16 cases) and secondary metastasis 7.69% (10 cases). The more common site was cervical 93.07% (121 cases), axillary 4.6% (6 cases), inguanal 1.5% (2 cases) and mesenteric 0.7% (1 case). Conclusions The most common pathological pattern seen was chronic nonspecific lymphadenopathy (46.6%) followed by tuberculosis lymphadenitis 18.46%, non-Hodgkin lymphoma 13.07%, Hodgkin lymphoma 12.30%, and secondary metastasis 7.69% and others 1.5%. It is more common in female than male, and the more common site is cervical lymphadenopathy 93.07%. The earlier diagnosis and management of tuberculosis and earlier diagnosis of malignancies before the onset of nodal metastases may explain the result.

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“…In the study by Panchal J et al 15 31.2% cases were tuberculous lymphadenitis, 15.6% were suppurative lymphadenitis, 20% were reactive hyperplasia, 11.1% BCG adenitis, 2.2% Kimura's disease, 15.6% were lymphoma and 4.4% were metastasis in lymph nodes (which is much lower than in the present study). In a recent study by Vachhani AB et al 16 the incidence of granulomatous lymphadenitis (24%) and lymphomas (2%) were lower, and nonspecific lymphadenitis (51%) and metastatic deposits (23%) were higher than in the present study. In a similar study by Ochicha et al 17 malignancies were higher comprising 43% of peripheral lymph nodes, with lymphomas predominating, accounting for 24 % compared to 4.47% in the present study.…”

Section: Discussioncontrasting

confidence: 51%

Histopathological study of Lymph node lesions

Vidyadhar¹,

S²,

K³

2014

JIMD

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Abstract:Lymph node biopsy and histopathological examination (HPE) is an extremely important investigation helpful in differentiating between reactive and neoplastic states including lymphomas, sarcomas, histiocytosis and leukemias. Lymph node biopsy is also helpful in differentiating between primary and secondary malignant lesions of the lymph node. The present study was carried out in the Department of Pathology, Kannur Medical College, Kannur, on patients with clinically palpable lymph nodes i.e. either localised or generalised lymphadenopathy. The cervical lymph node was excised in preference to axillary and inguinal nodes. Among the non-neoplastic lesions tuberculous lymphadenitis (34.2%) and among the neoplastic lesions, metastatic carcinomas (19.90%) were the most common. Lymphomas comprised approximately 4% of the cases. Non-neoplastic lesions were most common in the 20-30 year age group whereas neoplastic lesions were most common in the 51-60 year age group. HPE on properly selected and excised lymph nodes enables one to arrive at an accurate diagnosis.

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Histopathological study of lymph node biopsy

Cited by 11 publications

References 9 publications

A Descriptive Study of Histopathological Patterns of Lymph Node Biopsies In A Tertiary Care Hospital

A Descriptive Study of Histopathological Patterns of Lymph Node Biopsies In A Tertiary Care Hospital

Patterns of lymph node pathology using biopsy evaluation tool for lymphadenopathy: a retrospective descriptive study conducted at Al Hussein Medical City 2014–2016

Histopathological study of Lymph node lesions

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