Abstract:Lymph node biopsy and histopathological examination (HPE) is an extremely important investigation helpful in differentiating between reactive and neoplastic states including lymphomas, sarcomas, histiocytosis and leukemias. Lymph node biopsy is also helpful in differentiating between primary and secondary malignant lesions of the lymph node. The present study was carried out in the Department of Pathology, Kannur Medical College, Kannur, on patients with clinically palpable lymph nodes i.e. either localised or generalised lymphadenopathy. The cervical lymph node was excised in preference to axillary and inguinal nodes. Among the non-neoplastic lesions tuberculous lymphadenitis (34.2%) and among the neoplastic lesions, metastatic carcinomas (19.90%) were the most common. Lymphomas comprised approximately 4% of the cases. Non-neoplastic lesions were most common in the 20-30 year age group whereas neoplastic lesions were most common in the 51-60 year age group. HPE on properly selected and excised lymph nodes enables one to arrive at an accurate diagnosis.
Endometrial Stromal Sarcomas (ESS) are rare tumours arising from the endometrial stroma. The present retrospective study was conducted jointly at the Malabar Cancer Centre, Thalassery and Kannur Medical College, Kannur, Kerala, between June 2011 and June 2015. AIMTo study the age distribution, Histo-morphological features of ESS and to evaluate the prognostic factors of ESS. MATERIALS AND METHODSAll the cases diagnosed as ESS during study period were included and other endometrial malignancies were excluded. Of the 11 cases of ESS, 10 cases were detected at Malabar Cancer Centre, Thalassery, and 1 case at Kannur Medical College, Kannur. OBSERVATIONSThe frequency distribution of the tumour with relation to age is also evaluated. In addition to the classical morphological features, IHC for CD10 is of high value in diagnosis. ER and PR positivity may provide an avenue for hormonal therapy. RESULTSSignificant association was observed between FIGO staging and survival of subjects. As these tumours have tendency for late recurrence, long-term follow-up is essential; i.e. once in 3 months for first year, half yearly for next 4 years and annually thereafter. CONCLUSIONSESS is a rare entity and in addition to the classical morphological features, immune-staining for CD10 is of high value in its diagnosis. ER and PR positivity shows these tumours are amenable to hormonal therapy.
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