Histopathological spectrum of cervical biopsies – a 5 year retrospective study

Kumari, Kanya; Umarani, M K; Bharathi, M

doi:10.17511/jopm.2017.i01.08

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…The cervix is vulnerable to many pathological changes such as non-neoplastic and neoplastic lesions. (1,2). The nonneoplastic cervical lesions are distributed across all age groups, more commonly in sexually active women.…”

Section: Introductionmentioning

confidence: 99%

Histopathological study of cervical lesions: a hospital based study in teaching hospital Batticaloa, Sri Lanka

Thirukumar¹,

Ahilan

2020

Jaffna Med. J.

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The uterine cervix is prone for infections and malignancies. The cervical cancer is fourth most common cancer in the world and second common female cancer in Sri Lanka. This hospital based retrospective study was done on 586 cervical specimens. This study was aimed for the histomorphology patterns of cervical lesions. Results; There were 10.2% malignant cases and 68.90% were non-neoplastic cervical specimens. Majority of the non-neoplastic cervical lesions were inflammation and polyp, constitute 37.2% and 17.7% of the total study samples. Majority of patients with cervical carcinoma (36.5%) presented with blood-stained, whitish per vaginal discharge and it is followed by (32.7%) abnormal uterine bleeding. The peak age incidence of cervical cancer was 50-59 years. Squamous cell carcinoma was by far the most common histological type accounting for 84.6%, followed by adenocarcinoma 11.5%. Squamous cell cervical carcinoma classified according to Broder's grading system into well, moderately and poorly differentiated at the time of initial diagnosis and constituting cases as 20%, 71.1% and 8.9% respectively. The chronic nonspecific cervicitis was the most common inflammatory lesion constituting 86.2% of nonneoplastic cases.The main presenting complaints of blood-stained vaginal discharge or abnormal uterine bleeding, especially in the age group of 50-59 years, should be investigated to exclude malignancy. Public health education should be intensified to encourage early health seeking behavior in order to diagnose cervical malignancy at an early age especially when they have clinical symptoms of blood-stained vaginal discharge or abnormal uterine bleeding.

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Section: Introductionmentioning

confidence: 99%

Histopathological study of cervical lesions: a hospital based study in teaching hospital Batticaloa, Sri Lanka

Thirukumar¹,

Ahilan

2020

Jaffna Med. J.

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“…Cervicitis, in the index study, was the most common non-neoplastic lesion with most cases occurring in the fourth decade of life. Kumari et al also observed that cervicitis was the most common nonneoplastic lesion with majority of cases identified within 30-41 years of age [64]. Craig and Lowe, 2003, revealed a similar result with rarity of the lesion in females below twenty years in contrast to the report presented by Omoniyi-Esan et al, whose findings showed that 10% of cervicitis was observed in adolescence [65,66].…”

Section: Discussionmentioning

confidence: 88%

A 10-Year Histopathologic Audit of Uterine Cervical Biopsies in Warri, Nigeria

Odokuma

2019

Galician med. j.

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The objective of the research was to determine the types, patterns of uterine cervical lesions and specific age distributions in which they occur. Methods. The data for this study were obtained from the records of patients seen in consultations in the Department of Histopathology, Central Hospital Warri during the 10-year period from 2007 to 2016. Relevant clinical information was extracted from the available histopathology records and permission for this study was conformed with the provision of the Declaration of Helsinki in 1995. Results. The study revealed that the peak age range for malignant neoplasm was between 40-49 years (27.52%) with the general age range between (20-80 years) mean age 52.39±13.69. Non-keratinizing squamous cell carcinoma constituted majority of squamous cell tumours (55.05%), while the keratinising variety was the second most common (26.61%) one. The study further revealed that ectocervical fibroepithelial polyps were more common than endocervical tumours especially in the reproductive years (30-50 years) with only one case of atrophic polyp recorded in a woman in the sixth decade. The study documented that 58 (22.48%) of the cervical biopsies were inflammatory with most cases occurring in the ectocervix (94.80%). Most cases of inflammation of the cervix (cervicitis) were disposed between 30 and 59 years with the peak age group occurring in the 4th age group (30-39 years). Conclusions. This audit of uterine cervical biopsies established that malignant tumours were the most common neoplasms. Squamous cell carcinomas accounted for most carcinomas. Similarly, leiomyoma was demonstrated as predominant stromal tumour.

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“…In recent years, it has become clear that HPV plays a critical role in the pathogenesis of nearly all cervical squamous cell carcinomas [9]. In the study, lesions were classified as non-neoplastic, premalignant, or malignant, as in previous studies [7,8,[10][11][12].…”

Section: Discussionmentioning

confidence: 99%

A Study of Cervical Lesions in Correlation With Human Papillomavirus Analysis by Immunohistochemical Assay

REDDY,

NEERAJA,

KALAVATHI

2023

Asian J Pharm Clin Res

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Background: It has become clear that human papillomavirus (HPV) plays a critical role in the pathogenesis of nearly all cervical squamous cell carcinomas. Because HPV causes a variety of cervix lesions, including benign, premalignant, and malignant lesions, early detection of this infection benefits the patient. Objective: The goal of this study is to identify neoplastic and non-neoplastic cervix lesions, to study neoplastic and non-neoplastic cervix lesions caused by HPV in correlation with HPV analysis by immunohistochemistry (IHC), and to understand the significance of HPV in screening cervical lesions. Methods: The current study evaluated and compared HPV cocktail expression in 100 samples collected from 100 cases with cervical lesions. A semi-quantitative method was used to determine the positivity of the HPV cocktail. Comparison of expression of HPV cocktail IHC and histopathology was carried out. Results: Of the 100 cases, 30 were carcinoma cervix (CC), 4 were carcinoma in situ (CIS), 22 were squamous intraepithelial lesions (SIL), 20 were chronic cervicitis, 16 were chronic cervicitis with Koilocytic change, 7 were Koilocytic change, and 1 was Inflammatory polyp. SIL and CIS have a mean age of 46.8 and 44.5 years, respectively. There was a 42% incidence of carcinoma cases seen in the fourth decade, with a mean age of 45.9 years. The most common complaint presented by CC patients is AUB, with postmenopausal bleeding being the most common complaint. Seven patients with Squamous cell carcinoma present with postmenopausal bleeding. There were neoplastic lesions in 56% of the cases and non-neoplastic lesions in 44% of the cases. Premalignant cervix lesions include low grade squamous intra epithelial lesion, high grade squamous intra epithelial lesion, and CIS, which account for 46.42% of all cases. Non-neoplastic lesions such as chronic cervicitis account for 45.55% of all cases, followed by chronic cervicitis with Koilocytic change (36.36%), Koilocytic change (15.91%), and Polyp (2.27%). There were 28 Squamous cell carcinomas and 2 Adenocarcinomas among the 30 cases of CC. Squamous cell carcinoma accounted for 93.33% of all cases, while adenocarcinoma accounted for 6.67%. Moderately differentiated squamous cell carcinomas account for 86.66% of the cases, followed by well differentiated squamous cell carcinomas and poorly differentiated squamous cell carcinomas, which account for 6.66% of the cases. 26 (86.6%) of 30 squamous cell carcinomas tested positive for IHC. All two Adenocarcinoma cases (100%) and all CIS cases (100%) were positive. Out of the 22 SIL cases, 18 (81.81%) were positive. Out of 16 cases of chronic cervicitis with Koilocytic change, 14 (87.5%) were positive. Out of 20 chronic cervicitis cases, 12 (60%) were positive. 5 (71.43%) of the 7 cases of Koilocytic change were positive. Cervical lesions (benign, premalignant, and malignant) have a significant correlation with HPV cocktail IHC (p=0.01). Conclusion: The expression of the HPV cocktail was associated with clinical and histopathologic parameters in benign, premalignant, and malignant cervical lesions. Periodic follow-up allows patients to be better managed by providing vital data on the incidence of HPV infection in various cervical lesions. Low-grade SILs and high-grade SILs with HPV +ve infection can be monitored by HPV once a year instead of every 6 months. Patients over the age of 30 years with HPV-positive non-neoplastic cervical lesions can be monitored once every three years rather than annually. HPV is a biomarker for a better prognosis in cervical cancer, regardless of age, International Federation of Obstetricians and Gynecologists stage, or histologic type. HPV-positive tumors have a better prognosis.

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Histopathological spectrum of cervical biopsies – a 5 year retrospective study

Cited by 5 publications

References 7 publications

Histopathological study of cervical lesions: a hospital based study in teaching hospital Batticaloa, Sri Lanka

Histopathological study of cervical lesions: a hospital based study in teaching hospital Batticaloa, Sri Lanka

A 10-Year Histopathologic Audit of Uterine Cervical Biopsies in Warri, Nigeria

A Study of Cervical Lesions in Correlation With Human Papillomavirus Analysis by Immunohistochemical Assay

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