Histopathological Features of Nasal Polyps with Asthma Association: An Immunohistochemical Study

Haruna, Shinichi; Nakanishi, Márcio; Otori, Nobuyoshi; Moriyama, Hiroshi

doi:10.1177/194589240401800307

Cited by 61 publications

(49 citation statements)

References 19 publications

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“…A correlation was found between deposition of collagen type I and expression of IL‐11,9 and in another study IL‐17A was found to correlate with the degree of epithelial damage and BM thickness 25. CRS patients with concomitant asthma and/or aspirin intolerance have the highest grades of eosinophilic inflammation 26–30. A markedly thickened BM was also found to be associated with this group 31.…”

Section: Collagen Deposition and Fibrosis As An Irreversible End Stagmentioning

confidence: 86%

Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

2011

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Mucosal remodeling in the sinuses is a recently described phenomenon in which the mucosa undergoes potentially irreversible changes as a result of ongoing underlying inflammatory processes. Research into remodeling that occurs in the bronchial airways in asthmatic patients has led to modification of asthma treatment guidelines. However, remodeling in the sinuses has still not led to changes in current medical or surgical management of chronic rhinosinusitis. Upper airway remodeling constitutes a new area of research that poses many unanswered clinical questions and may potentially alter the management of patients with severe chronic rhinosinusitis.

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Section: Collagen Deposition and Fibrosis As An Irreversible End Stagmentioning

confidence: 86%

Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

2011

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“…Their activation induced significantly higher rate of proteoglycan synthesis (93). In nasal polyps, the increased number of myofibroblasts in asthmatics may be responsible for the ECM accumulation, polyp formation and recurrence (94). Compared with normal nasal tissue, collagen types I, III and V were significantly more abundant in the submucosal connective tissue and in the basement zone on nasal polyps, this deposition being irreversible after treatment with topical glucocorticosteroids (95).…”

Section: Fibroblasts In Pathological Airwaysmentioning

confidence: 96%

Tissue remodelling in upper airways: where is the link with lower airway remodelling?

Watelet

Zele

Gjomarkaj

et al. 2006

Allergy

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Tissue remodelling reported in upper airways include epithelial hyperplasia, increased matrix deposition in the nasal or paranasal lining, matrix degradation and accumulation of plasma proteins. Genetic influences, foetal exposures and early life events may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of the disease and long-term uncontrolled inflammation. Structural changes may increase alteration of the protective functions of the upper airways namely by affecting mucociliary clearance and conditioning of inspired air. The sequences of tissue changes during wound repair of upper airway mucosa after surgery are illustrative of the complexicity of tissue modelling and remodelling and could be considered as an important source of information for a better understanding of the complex relationship between inflammatory reaction, of the subsequent tissue damages and fibroblast metabolism of upper airways

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“…10 Moreover, it has also been shown that eosinophil recruitment plays an essential role in the inflammatory response that characterizes AERD. 11,12 For example, eosinophil numbers obtained in bronchial biopsy specimens and NPs derived from AERD patients are fourfold greater than in airway biopsy specimens from aspirin-tolerant asthmatic patients and 15-fold more numerous than in healthy subjects. 13 Because there is limited literature concerning the incidence of AERD among the Chinese CRS population, it is difficult to draw a solid conclusion on risk factors underlying AERD development.…”

Section: Discussionmentioning

confidence: 99%

Aspirin-exacerbated Respiratory Disease in China: A Cohort Investigation and Literature Review

Fan

Feng

Xia

et al. 2012

Am J Rhinol�Allergy

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Histopathological Features of Nasal Polyps with Asthma Association: An Immunohistochemical Study

Abstract: The increased number of myofibroblasts in the nasal polyps of the asthma group may be responsible for the extracellular matrix accumulation, polyp formation, and polyp recurrence.

Cited by 61 publications

References 19 publications

Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

Tissue remodelling in upper airways: where is the link with lower airway remodelling?

Aspirin-exacerbated Respiratory Disease in China: A Cohort Investigation and Literature Review

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