“…In a recent random sample survey study with over 52,000 adults aged 18 to 75 years in 12 European countries, the prevalence of self-reported current asthma (5.1-16.8%) was found to be strongly associated with CRS appropriate symptoms (adjusted OR, 3.47; 95% CI, 3.20 to 3.76) in all ages, in both men and women, irrespective of smoking behavior. 293 The reported incidence of asthma varies from 2% to 38% in patients with CRS, [294][295][296][297][298][299] 2% to 66% in CRSwNP, 289, and 68% to 91% in refractory CRSwNP. 290,299 Among these reports, the prevalence of asthma in patients with CRSsNP or CRSwNP appears to be lower in Asians than whites.…”
Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS).
Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus.
Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS.
Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC.
Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery
List of Abbreviations Used
“…In a recent random sample survey study with over 52,000 adults aged 18 to 75 years in 12 European countries, the prevalence of self-reported current asthma (5.1-16.8%) was found to be strongly associated with CRS appropriate symptoms (adjusted OR, 3.47; 95% CI, 3.20 to 3.76) in all ages, in both men and women, irrespective of smoking behavior. 293 The reported incidence of asthma varies from 2% to 38% in patients with CRS, [294][295][296][297][298][299] 2% to 66% in CRSwNP, 289, and 68% to 91% in refractory CRSwNP. 290,299 Among these reports, the prevalence of asthma in patients with CRSsNP or CRSwNP appears to be lower in Asians than whites.…”
Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS).
Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus.
Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS.
Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC.
Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery
List of Abbreviations Used
“…Specifically, in some regions of Asia, it has recently been shown that some CRSwNP cases (nearly 50%) are more likely to be associated with a noneosinophilic or neutrophilic infiltrate and Th1/17 cytokine skewing [41][42][43][44]. In correlation with reduced eosinophilic inflammation, we also observed a very low rate of concomitant asthma and aspirin-exacerbated respiratory disease in Chinese CRSwNP patients [45,46]. It is also interesting to note that over a 12-year period (from 1999 to 2011), a shift from predominantly neutrophilic to eosinophilic inflammation was recently reported in Asian (Thai) patients with CRSwNPs in association with an increase in the intramucosal presence of Staphylococcus aureus [47].…”
Section: Endotypes Of Chronic Rhinosinusitis: Eosinophilic Versus Nonmentioning
These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS. Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function and enhanced bacterial colonization. The use of SPLUNC1 as a therapeutic target for CRSwNP remains to be determined.
“…These observations would in turn suggest that Asian patients, given their relative paucity of tissue eosinophils, might be less likely to have AERD. This is supported by one small study from China that found the prevalence of AERD to be 0.57% among patients evaluated with CRSwNP 48 , which is must lower than the 9–10% estimated in a meta-analysis of patients predominantly of European descent 6 . Second generation Asians with CRSwNP in the US also had less atopy and less comorbidity with asthma than non Asian Americans.…”
Section: Disease Pathophysiologymentioning
confidence: 74%
“…mast cells, eosinophils, and basophils), it is not surprising that there are elevations in levels of traditional type-2 inflammatory mediators in AERD and also in CRSwNP nasal polyps when compared to healthy sinonasal tissue (e.g. IL-5, IL-4, IL-13, Eotaxin-1 Eotaxin-2) 43, 4448, 45, 75, 76 .…”
Synopsis
Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both diseases characterized by the presence of chronic sinonasal inflammation and nasal polyps. Both diseases are associated with asthma; AERD by definition and CRSwNP by common comorbidity (~50%). Therefore, the most prominent clinical feature distinguishing patients with AERD from those with CRSwNP remains the development of an upper or lower respiratory tract reaction following the ingestion of a COX-1 inhibitor. However, even in the absence of COX-1 inhibitors, there are other notable clinical and pathophysiological differences between AERD and CRSwNP patients. Patients with AERD on average have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to patients with CRSwNP. While no single genetic factor has been identified in either CRSwNP or AERD pathogenesis to date, many studies have evaluated whether there are differences in the underlying cellular and molecular mechanisms that account for the observed clinical variations. Studies from several laboratories have discovered important differences in the metabolism of arachidonic acid, including increased activity of the 5-lipoxygenase pathway and decreased levels of the anti-inflammatory prostanoid PGE2. Clear evidence for activation of platelets in AERD also distinguishes it from CRSwNP. Nasal polyp tissues from both AERD and CRSwNP are characterized by type-2 inflammation but there are significantly increased levels of eosinophil and mast cell degranulation products in AERD sinonasal tissue, and recent evidence suggesting that spontaneous activation of eosinophils, basophils and mast cells occurs.
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