Histopathologic evaluation of the effects of propolis (cape) in the experimental spinal cord injury

Abstract

CAPE has a positive effect on spinal cord injuries by preventing apoptosis.

CAPE and Neuroprotection: A Review

“…Another study compared the effects of CAPE with those of methylprednisolone (MP) in the prevention of neurological deficits caused by secondary spinal cord injury. CAPE has been found to be superior to MP in preventing apoptosis without showing the latter side effects-namely, gastrointestinal hemorrhage and infection [70]. The effects of intrathecal CAPE administration following SCI were investigated as an alternative approach in CNS diseases because the systemic administration of pharmacological agents does not guarantee the attainment of the maximum effective dose in the damaged area.…”

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

“…In the last two years, many research studies, focusing on the identification of drugs potentially effective in SCI treatment, have been published [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ,…”

“…Histopathological evaluation and neurological examination demonstrated that GL polysaccharides have in the SCI animal model an effect comparable to that obtained in an animal control group treated with intraperitoneal injection of MP [ 44 ]. Also Caffeic acid and Mangiferin show comparable in vivo effects to MP [ 36 , 48 ].…”

Effects of intrathecal caffeic acid phenethyl ester (cape) on il-6 and tnf-α levels and local inflammatory responses in spinal cord injuries

“…They reported that CAPE contributes to the healing process by suppressing the levels of pro-inflammatory cytokines. In addition, Aydin et al observed that intraperitoneal CAPE administration had a positive effect on spinal cord injury models by preventing apoptosis (2). No previous studies have evaluated the effects of intrathecal CAPE administration on IL-6 and TNF-α levels following traumatic SCI as well as on inflammation-induced edema and microhemorrhage.…”