Effects of intrathecal caffeic acid phenethyl ester (cape) on il-6 and tnf-&amp;#945; levels and local inflammatory responses in spinal cord injuries

Akgun, Bekir; Öztürk, Sait; Artaş, Gökhan; Erol, Fatih Serhat

doi:10.5137/1019-5149.jtn.20011-17.1

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Intrathecal injection of 1 μg/kg caffeic acid phenethyl ester after SCI led to a decrease in MDA, LPO, and total oxidant activity. It increased antioxidative agents [109], while decreasing tissue and serum levels of IL-6 post-SCI [110]. In this line, Ak et al confirmed the effects of i.p.…”

Section: Caffeic Acid Phenethylmentioning

confidence: 95%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

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Section: Caffeic Acid Phenethylmentioning

confidence: 95%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…MDA, LPO, and total oxidant action were reduced after SCI with an intrathecal infusion of 1 g/kg caffeic acid phenethyl ester. After SCI, it boosted antioxidative mediators [ 240 ], even as it decreased IL-6 levels in tissue and serum [ 241 ]. In a similar vein, Ak et al found that caffeic acid phenethyl ester (10 g/kg) infusions lowered TNF- α and IL-1 β levels after SCI [ 179 ].…”

Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

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A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration’s extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.

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“…Although no significant decrease was identified in the TNF-α level, CAPE led to a decrease in the edema and microhemorrhage that developed in association with a local inflammatory response in the damaged area. In addition, CAPE was more effective than MP in decreasing microhemorrhage [71]. Interestingly, the intratechal administration of CAPE and MP decreased also the MDA, TOA, and SOD levels, with a greater effect in the CAPE group [72].…”

Section: Cape Protective Effects Against Injurymentioning

confidence: 99%

CAPE and Neuroprotection: A Review

et al. 2021

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Propolis, a product of the honey bee, has been used in traditional medicine for many years. A hydrophobic bioactive polyphenolic ester, caffeic acid phenethyl ester (CAPE), is one of the most extensively investigated active components of propolis. Several studies have indicated that CAPE has a broad spectrum of pharmacological activities as anti-oxidant, anti-inflammatory, anti-viral, anti-fungal, anti-proliferative, and anti-neoplastic properties. This review largely describes CAPE neuroprotective effects in many different conditions and summarizes its molecular mechanisms of action. CAPE was found to have a neuroprotective effect on different neurodegenerative disorders. At the basis of these effects, CAPE has the ability to protect neurons from several underlying causes of various human neurologic diseases, such as oxidative stress, apoptosis dysregulation, and brain inflammation. CAPE can also protect the nervous system from some diseases which negatively affect it, such as diabetes, septic shock, and hepatic encephalopathy, while numerous studies have demonstrated the neuroprotective effects of CAPE against adverse reactions induced by different neurotoxic substances. The potential role of CAPE in protecting the central nervous system (CNS) from secondary injury following various CNS ischemic conditions and CAPE anti-cancer activity in CNS is also reviewed. The structure–activity relationship of CAPE synthetic derivatives is discussed as well.

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Effects of intrathecal caffeic acid phenethyl ester (cape) on il-6 and tnf-α levels and local inflammatory responses in spinal cord injuries

Abstract: Intrathecal CAPE administration following SCI decreases tissue and serum IL-6 levels as well as decreases spinal cord edema and microhemorrage.

Cited by 4 publications

References 9 publications

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

CAPE and Neuroprotection: A Review

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