Histone Deacetylases as Cancer Chemoprevention Targets for Natural Products

Ho, Raimana; Nievergelt, Andreas; Pires, C. Simoes; Cuendet, Muriel

doi:10.1016/b978-0-444-59530-0.00009-5

Cited by 3 publications

(2 citation statements)

References 153 publications

(163 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some examples are butyrate, organosulfur and organoselenium compounds, as well as polyphenols. 9 Among flavonoids, a common group of plant phenolic compounds, 10 some isoflavones and flavones are known as in vitro HDAC inhibitors. [11][12][13] Considering this, the HDAC inhibitory activity of another flavonoid subgroup, the aurones, was investigated in the present study.…”

Section: Introductionmentioning

confidence: 99%

Aurones as histone deacetylase inhibitors: Identification of key features

Zwick

Chatzivasileiou

Deschamps

et al. 2014

Bioorganic & Medicinal Chemistry Letters

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Aurones as histone deacetylase inhibitors: Identification of key features

Zwick

Chatzivasileiou

Deschamps

et al. 2014

Bioorganic & Medicinal Chemistry Letters

Self Cite

View full text Add to dashboard Cite

“…Particularly salient is SIRT1's adeptness at curtailing ROS levels, fostering cellular survival, and offering defense against oxidative stress by manipulating transcription factors, notably the p53 and FOXO families [ 99 ]. Its anti-apoptotic attributes are further emphasized by its deacetylation of pivotal proteins, among which are Ku70, PARP, Smad7, and HSF1 [ 100 ].…”

Section: Mechanistic Insights Into Lactic Acid Bacteria and Longevity...mentioning

confidence: 99%

Lactic Acid Bacteria and Aging: Unraveling the Interplay for Healthy Longevity

Liu,

Sun

2023

Aging and disease

View full text Add to dashboard Cite

Lactic Acid Bacteria (LAB) are beneficial microorganisms widely utilized in food fermentation processes and as probiotic supplements. They offer multifarious health benefits, including enhancing digestion, strengthening immune mechanisms, and mitigating inflammation. Recent studies suggest that LAB might be instrumental in the anti-aging domain, modulating key molecular pathways involved in the aging continuum, such as IL-13, TNF-α, mTOR, IFN-γ, TGF-β, AMPK, and GABA. The TLR family, particularly TLR2, appears pivotal during the primary cellular interactions with bacteria and their byproducts. Concurrently, the Sirtuin family, predominantly Sirtuin-1, plays diverse roles upon cellular stimuli by bacterial components. The potential anti-aging benefits postulated include restoring gut balance, enhancing antioxidant potential, and fortifying cognitive and mental faculties. However, the current body of evidence is still embryonic and calls for expansive human trials and deeper mechanistic analyses. The safety and optimal consumption metrics for LAB also warrant rigorous evaluation. Future research trajectories should identify specific LAB strains with potent antiaging properties and unravel the underlying biological pathways. Given the promising implications, LAB strains stand as potential dietary contenders to foster healthy aging and enrich the quality of life among the elderly population.

show abstract