Cancer chemopreventive diterpenes from Salvia corrugata

Giacomelli, Emanuela; Bertrand, Samuel; Nievergelt, Andreas; Zwick, Vincent; Simões-Pires, Cláudia A.; Marcourt, Laurence; Rivara‐Minten, Elisabeth; Cuendet, Muriel; Bisio, Angela; Wolfender, Jean‐Luc

doi:10.1016/j.phytochem.2013.09.011

Cited by 25 publications

(22 citation statements)

References 44 publications

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“…Fruticulin A is a rare compound and was reported in only two other species of Salvia, S. fruticulosa [28] and S. corrugata [29]. Previous studies showed antibacterial [29, 30] and cancer chemopreventive activities of fruticulin A [31], but anti-inflammatory assays had not been performed with this compound. To test the contribution of fruticulin A to the activities observed in the extract, we tested the compound for anti-inflammatory and antihyperalgesic activities.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Piccinelli

Aquino

Morato

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The anti-inflammatory and analgesic effects of the ethanolic extract (SLEE) and fruticulin A from the leaves of Salvia lachnostachys were evaluated in mice, using experimental models of inflammation (paw oedema and pleurisy induced by carrageenan injection) and hyperalgesia (electronic Von Frey). Oral administration of SLEE (30, 100, and 300 mg/kg) and fruticulin A (0.3 and 3.0 mg/kg) decreased the total leucocytes number in pleural lavage, protein extravasation, and paw oedema. SLEE (100 mg/kg) and fruticulin A (3 mg/kg) also exhibited antihyperalgesic activity in carrageenan induced mechanical hyperalgesia. In addition, fruticulin A (3 mg/kg) prevented mechanical hyperalgesia, inhibiting TNF but not L-DOPA-induced mechanical hyperalgesia. In conclusion, SLEE and fruticulin A display anti-inflammatory and analgesic properties. Therefore, fruticulin A is at least partially responsible for the activity observed in the ethanolic extract of Salvia lachnostachys.

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Piccinelli

Aquino

Morato

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Chemopreventive Salvia corrugata Fruticulin C, 7α-methoxy-19-acetoxyroyleanone, 7α,19-diacetoxy-royleanone, and 7-dehydroxy-conacytone exhibited chemopreventive activity (IC 50 : 0.06-59.5 μM) by quinone reductase induction activity and histone deacetylase inhibition tests. Giacomelli et al [2013] Hedychium coronarium Isocoronarin D, methoxycoronarin D, ethoxycoronarin D and benzoyl eugenol inhibited NF-kB, COX-1 and COX-2 (IC 50 : 0.9-57.6 μM).…”

Section: Zhan Et Al [2015]mentioning

confidence: 98%

Therapeutic Potential of Essential Oils Focusing on Diterpenes

et al. 2016

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Among all plant derivates, essential oils (EOs) have gained the attention of many scientists. Diterpenes, a family of components present in some EO, are becoming a milestone in the EOs world. The goal of this review is to describe a scenario of diterpenes taking into health-consumption deportment. Previous studies revealed that diterpenes have antioxidant, antimicrobial, antiviral, antiprotozoal, cytotoxic, anticancer, antigenotoxic, antimutagenic, chemopreventive, antiinflammatory, antinociceptive, immunostimulatory, organoprotective, antidiabetic, lipid-lowering, antiallergic, antiplatelet, antithrombotic, and antitoxin activities. In conclusion, diterpenes may be an immense featuring concern in pharmaceutical consumption from a drug discovery point of view. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Moreover, the detection of the level of oxidative stress is crucial prior to a particular antioxidant therapy (Islam et al, 2016c). It is mentioned that, to date, a number of diterpenes such as fruticulin C, 7α-methoxy-19acetoxy-royleanone, 7α,19-diacetoxy-royleanone, 7dehydroxy-conacytone (Giacomelli et al, 2013), isocoronarin D, methoxycoronarin D, ethoxycoronarin D and benzoyl eugenol (Endringer et al, 2014) have been reported to have chemopreventive capacity in a number of human cells. In a study, cafestol palmitate and kahweol palmitate at 75 and 100 μM did not disturb the angiogensis and proliferation in normal human microvascular dermal endothelial cells (Moeenfard et al, 2016).…”

Section: Challenges and Safety Promises Of Diterpenesmentioning

confidence: 99%

Diterpenes and Their Derivatives as Potential Anticancer Agents

Islam

2017

Phytotherapy Research

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As therapeutic tools, diterpenes and their derivatives have gained much attention of the medicinal scientists nowadays. It is due to their pledging and important biological activities. This review congregates the anticancer diterpenes. For this, a search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases from January 2012 to January 2017 for the published articles. A total 28, 789 published articles were seen. Among them, 240 were included in this study. More than 250 important anticancer diterpenes and their derivatives were seen in the databases, acting in the different pathways. Some of them are already under clinical trials, while others are in the nonclinical and/or pre-clinical trials. In conclusion, diterpenes may be one of the lead molecules in the treatment of cancer. Copyright © 2017 John Wiley & Sons, Ltd.

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Cancer chemopreventive diterpenes from Salvia corrugata

Cited by 25 publications

References 44 publications

Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Therapeutic Potential of Essential Oils Focusing on Diterpenes

Diterpenes and Their Derivatives as Potential Anticancer Agents

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