Therapeutic Potential of Essential Oils Focusing on Diterpenes

Islam, Muhammad Torequl; Mata, Ana M.; Aguiar, Rai Pablo Sousa de; Paz, Márcia Fernanda Correia Jardim; Alencar, Marcus Viní­cius Oliveira Barros de; Ferreira, Paulo Michel Pinheiro; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.1002/ptr.5652

Cited by 78 publications

(68 citation statements)

References 227 publications

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“…25 It has suggested that reducing viral load and cytokines levels by therapy, could prevent or lessen the chances of patients progressing to severe disease. 3,4 Owing to their antiviral and anti-inflammatory properties, [17][18][19] terpenes could have strong potential for being used in the search of new drugs for dengue. This study aimed to evaluate the antiviral activity in vitro of compounds found in essential oils with anti-dengue activity.…”

Section: Discussionmentioning

confidence: 99%

“…There is an increasing interest on these compounds because of their antimicrobial, antitumoral and anti-inflammatory properties. 17,18,19 Thus, terpenes and terpenoids offer a great opportunity to find novel lead molecules with specific inhibitory mechanisms on DENV. Antiviral activity of terpenes against Flavivirus have been demonstrated: citral blocked the Yellow-Fever Virus replication in vitro, 15 and treatment with combined monoterpenes delayed morbidity of mice due to West Nile Virus infection.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Flechas¹,

Ocazionez²,

Stashenko³

2017

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Introduction:There are not effective drugs available for treatment of dengue fever despite intensive research on synthetic inhibitors. The search for active phytochemicals could serve for the discovery of new drugs. This study aims to evaluate the antiviral activity in vitro of compounds found in essential oils from medicinal plants. Materials and Methods: Nine synthetic-derived essential oil compounds were evaluated. Antiviral effect was screened measuring the reduction of viral NS1 and E proteins in HepG-2 and Vero cells. Results: β-Caryophyllene was identified as the most active compound, it reduced the virus serotype-2 replication in HepG-2 cells at IC 50 of 22 ± 5.6 µM, and blocked replication of all four serotypes in Vero cells at IC 50 between 8.0 µM and 15.0 µM. The selectivity indexes were between 5.3 and 10. According to results from time-in-addition assays, the antiviral effect of β-caryophyllene appears to be associated with interruption of early steps of the virus life cycle. Citral revealed modest antiviral effect, it reduced the virus serotype-2 (IC 50 of 31 ± 4.5 µM) replication but not the other three serotypes. Seven terpenes did not reveal antiviral activity at maximum concentration of 30 µM. Conclusion: Research on compounds found in essential oils can contribute to the drug discovery effort for dengue. β-Caryophyllene could serve as a starting point.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Flechas¹,

Ocazionez²,

Stashenko³

2017

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“…According to Islam et al (2016a), about 25% pharmaceutically consumed drugs are derived from natural origins. Plants are the potential sources in this context.…”

Section: Introductionmentioning

confidence: 99%

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

Karim

Islam

Tareq

et al. 2017

IJM

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Solanum violaceum Ortega has been used by the traditional medicine practitioners in pain and fever. This study aimed at investigating anti-nociceptive and antipyretic activities of methanol extract of leaf (MELSV), fruit (MEFSV) and root (MERSV) of S. violaceum in Swiss albino mice. Anti-nociceptive activity was evaluated using hot plate method while antipyretic by brewer's yeast induced hyperpyrexia. In both tests, test animals were divided into eight groups of six in each. The groups were treated as negative control (distilled water), standard and tests (250 and 500 mg/kg of MELSV/ MERSV/ MERSV). Diclofenac sodium (150 mg/kg) and paracetamol (150 mg/kg) were taken as standards for anti-nociceptive and antipyretic tests, respectively. All the treatments were administrated via oral gavages (p.o.). Results suggest that, the plant extracts dose-dependently increased retention time compared to the control groups. MELSV at 500 mg/kg significantly increased retention time on the hot-pate of the test animals than the MEFSV and MERSV treated groups. In the antipyretic test, both 250 and 500 mg/kg of MELSV and 500 mg/kg of MEFSV significantly (p <0.05) decreased temperature to the experimental animals 30, 60, 120 minutes. In conclusion, the crude extracts of S. violaceum exhibited anti-nociceptive and antipyretic activities. S. violaceum may be one of the good sources of anti-nociceptive and antipyretic compounds.

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“…The contribution of medicinal plants in the modern medicines is vast and increasing day by day. It is due to the presence of abundant phytochemicals in a small amount of plant sample (Rao and Arora 2014; Islam et al 2016a). This study aimed to evaluate an antipyretic, analgesic and anti-inflammatory activity of the meth- …”

Section: Introductionmentioning

confidence: 99%

Antipyretic, analgesic and anti-inflammatory activity of the methanol Mimosa himalayana extract

Hossain

Bashar

Ibrahim

et al. 2017

IJM

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The aim of the study was to evaluate antipyretic, analgesic and anti-inflammatory activities of the methanol extract of Mimosa himalayana Gamble (Fabaceae) along with a preliminary phytochemical screening. The antipyretic and analgesic effects were tested in Swiss mice, while anti-inflammatory in egg albumin, taking paracetamol, diclofenac sodium and acetyl salicylic acid as standards, respectively. The results suggest that, the crude stem extract of M. himalayana revealed the presence of alkaloids, glycosides, saponins and gums. It exhibited antipyretic and analgesic activity at 200 and 400 mg/kg, while anti-inflammatory at 40, 80 and 160 µg/mL in the test systems. The activities were significant (p <0.05) in comparison to the negative control group with a high dose/concentration-mediated higher response manner. We suppose the alkaloids and glycosides may contribute its anti-inflammatory potential, which may link to the antipyretic and analgesic effects of the M. himalayana. In conclusion, M. himalayana may be one of the best sources of plant-based medicines, especially anti-inflammatory agents.

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Therapeutic Potential of Essential Oils Focusing on Diterpenes

Cited by 78 publications

References 227 publications

Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

Antipyretic, analgesic and anti-inflammatory activity of the methanol Mimosa himalayana extract

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