Histomorphometric and immunohistochemical assessment of RUNX2 and VEGF of Biogran™ and autogenous bone graft in human maxillary sinus bone augmentation: A prospective and randomized study

Abstract

This study demonstrates that Biogran and its combination with autogenous bone graft 1:1 are good bone substitutes due to their similarity to autogenous bone graft.

Do osteoconductive bone substitutes result in similar bone regeneration for maxillary sinus augmentation when compared to osteogenic and osteoinductive bone grafts? A systematic review and frequentist network meta-analysis

“…For the outcome of overall NBF, the total sample consisted of 1483 biopsies in 52 RCTs on MSA . The grafting materials were AB alone (n = 16 trials; 215 biopsies) 37,39,41,43,44,52,54,58,65,68,71,73,76,80,81,83 , AG alone (n = 6 trials; 78 biopsies) 47,49,57,73,74,83 , XG alone (n = 27 trials; 365 biopsies) 36,38,42,43,45,46,[48][49][50][51]53,55,56,59,60,[62][63][64]66,67,73,75,[77][78][79]82,85 , AP alone (n = 19 trials, 263 biopsies) 35,…”

“…For the mean percentage NBF with a healing time of !6 months, a total of 872 biopsies were included in 37 RCTs consisting of 10 groups. These RCTs compared different bone grafting materials and investigated the amount of new bone after at least 6 months following MS Q16 A 36,38,[40][41][42][43][44][47][48][49][50][51][52][53][54]57,[59][60][61][62][63][64][65]67,[74][75][76][77][78][79][80][81][82][83][84][85][86] . There was statistically significant superiority of AB with respect to AP alone (WMD = À7.06%, 95% CI À 12.59% to À1.52%).…”

“…For the mean percentage CT over a healing time of !6 months, a total of 564 biopsies in 22 RCTs involving 10 groups were included 40,[42][43][44][48][49][50][51]53,57,59,[62][63][64][65]74,75,80,82,83,85,86 . The CT% in the BMP-2 group was significantly lower than that in the AB alone group (WMD = 23.85%, 95% CI 6.42% to 41.27%).…”

In vitro and in vivo effects of a novel bioactive glass‐based cement used as a direct pulp capping agent

“…Bioactive glasses show a clinical ability to bond to bones, which is due to the formation of a biologically active layer of hydroxyapatite on the glass surface without the formation of surrounding fibrous tissue . The bioactive glass compounds have been used in the field of orthopedic surgery for bone engineering and are expected to have application in dental treatment . Furthermore, recent studies indicated that bioactive glass showed same ability with MTA about the induction of reparative dentin formation and exhibited inflammatory pulp responses as the direct pulp capping agent …”

Current and future options for dental pulp therapy

“…Bioactive glasses, one of the bioceramics comprised of silica (SiO 2 ), sodium oxide (Na 2 O), calcium oxide (CaO), and phosphorus pentoxide (P 2 O 5 ), are well-studied biomaterials [48]. Because bioactive glasses show a clinical ability to bond with bone through the formation of a hydroxyapatite layer on the surface [49], [50], they have been used in the field of orthopedic surgery for bone engineering [51], [52]. We hypothesized that bioactive glasses could be used in dental treatment, and we have recently developed bioactive glass-based cement [53].…”