Histology with immunohistochemistry of the fistula region in female anorectal malformation: Can it be used for neo‐anus reconstruction?

Pandey, Anand; Pandey, Pinki; Singh, Shailendra; Agarwal, Savita; Gupta, Viney; Verma, Rajesh

doi:10.1111/jpc.13691

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In addition, several studies also reported that the density and distribution of ganglia gradually decreased distally along the rectum, consistent with reports by others. [ 27 , 28 ] Kenny et al [ 29 ] observed alteration in density and distribution of ICC in most of their cases with 16% of cases showing complete absence of these cells. In our study, the expression of C-kit in ARM group is significantly decreased compared with that in control group, and there exists significant alteration in density and distribution of ICC in ARM group.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic and immunohistochemical findings in congenital anorectal malformations

Xiao

Huang²,

Cui³

et al. 2018

Medicine

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Section: Discussionmentioning

confidence: 99%

Histopathologic and immunohistochemical findings in congenital anorectal malformations

Xiao

Huang²,

Cui³

et al. 2018

Medicine

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“…Requirements for lipids or other nutritional components may also contribute to these effects. In a recent cohort study, higher early lipid intake and enteral feed volumes were associated with improved outcome to 2 years in girls, but not boys [189]. Preterm girls were more likely to achieve survival free from neurodevelopmental impairment (147 (82%) vs. 156 (72%), p = 0.02).…”

Section: Possible Reasons Why Research Has Not Yet Shown Whether mentioning

confidence: 99%

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

et al. 2019

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Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses.

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“…The other factor for delayed diagnosis includes financial issues and ignorance on the part of parents. [11]. Of the five patients waiting for PSARP, one is 12-year-old.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and management of rectovaginal fistula in anorectal malformation: an observational study

et al. 2021

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Purpose The rectovaginal fistula (RVF) is a type of female ARM in which the rectum terminates in the vagina. Due to its rarity, there are limited reports on its presentation, management, and follow-up. This paper deals with the clinical presentation, management, and outcome of RVF. Methods It was a retrospective cohort study of 10 years. The patients were evaluated for age, clinical presentation, associated anomalies, any prior surgical interventions performed elsewhere, and complications. After workup, the patients underwent three stages of surgery. Results Fifty-six patients of RVF were managed. The median age was 13.48 months. The associated anomalies were present in 37 (66%) patients. Posterosagittal and anterosagittal anorectoplasty (PSARP and ASARP) were performed in 29 and 6 patients, respectively. Abdominoperineal pull-through (APPT) was performed in 16 patients of congenital pouch colon. The complications of the first stage included stomal stenosis (4) and stomal prolapse (3). Constipation was present in 39 patients 2 years after the third surgery. Conclusions RVF is a distinct entity, which needs careful clinical examination. With proper planning for diagnosis and treatment, it can be managed at specialized centers. Care may be needed for the associated anomalies. The follow-up is an integral part of its management.

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Histology with immunohistochemistry of the fistula region in female anorectal malformation: Can it be used for neo‐anus reconstruction?

Abstract: The fistula region in VF and AEA patients appears to be an abnormal structure. Rather than preservation of the terminal fistulous region, resection followed by anoplasty may be a viable option.

Cited by 7 publications

References 15 publications

Histopathologic and immunohistochemical findings in congenital anorectal malformations

Histopathologic and immunohistochemical findings in congenital anorectal malformations

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

Evaluation and management of rectovaginal fistula in anorectal malformation: an observational study

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