Histology of the Parapapillary Region in High Myopia

Jonas, Jost B.; Jonas, Shefali B.; Jonas, Rahul A.; Holbach, Leonard M.; Panda‐Jonas, Songhomitra

doi:10.1016/j.ajo.2011.05.006

Cited by 119 publications

(96 citation statements)

References 28 publications

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“…Beta zone was characterized by visible sclera and visible large choroidal vessels and a location between the peripapillary scleral ring and alpha zone. Correspondingly, histological studies in human eyes and monkey globes confirmed in clinical histological correlations that alpha zone corresponded histologically to irregularities in the retinal pigment epithelium (RPE), and that beta zone showed a complete loss of RPE cells and an almost complete loss of photoreceptors and a closure of the choriocapillaris [2][3][4][5]. This scheme of only two zones in the parapapillary region has recently been challenged.…”

Section: Introductionmentioning

confidence: 92%

Parapapillary atrophy: histological gamma zone and delta zone

Jonas¹,

Jonas²,

Jonas³

et al. 2012

Acta Ophthalmologica

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Section: Introductionmentioning

confidence: 92%

Parapapillary atrophy: histological gamma zone and delta zone

Jonas¹,

Jonas²,

Jonas³

et al. 2012

Acta Ophthalmologica

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“…[10][11][12]34,39,[53][54][55][56][57][58] The models in this study did not account for LC microarchitecture, which in humans is not fully characterized, 44 but that animal models suggest may alter the local levels of IOPinduced stress and strain(Kodiyalam S, et al IOVS 2009;50:AR-VO E-Abstract 4893). 17,18 The authors are developing FE models that incorporate more realistic anatomies (like the variations in scleral shell thickness 59 ), material properties (anisotropic and nonlinear scleral properties, 29,33,49 lamina cribrosa anisotropy and inhomogeneity 17,43,45 ), and loading (larger IOP insult and cerebrospinal fluid pressure 57,[60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

The Optic Nerve Head as a Robust Biomechanical System

Sigal

Bilonick

Kagemann

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Understanding the effects of IOP on the optic nerve head (ONH) is important in understanding glaucoma and ONH structure and function. The authors tested the hypothesis that the ONH is a robust biomechanical structure wherein various factors combine to produce a relatively stable response to IOP. METHODS.The authors generated two populations of 100,000 ONH numerical models each with randomly selected values, but controlled distributions, either uniform or Gaussian, of ONH geometry and mechanical properties. The authors predicted the lamina cribrosa displacement (LCD), scleral canal expansion (SCE), and the stresses (forces) and deformations (strains) produced by a 10 mm Hg increase in IOP. The authors analyzed the distributions of the responses.RESULTS. The responses were distributed nonuniformly, with the majority of the models having a response within a small region, often less than 30% of the size of the overall response region. This concentration of responses was more marked in the Gaussian population than in the uniform population. All the responses were positively skewed. Whether a particular case was typical or not depended on the response used for classification and on whether the decision was made using onedimensional or two-dimensional criteria. CONCLUSIONS. Despite wide variations in ONH characteristicsand responses to IOP, some responses were much more common than others. This supports conceiving of the eye as a robust structure, particularly for LCD and SCE, which is tolerant to variations in tissue geometry and mechanical properties. The authors also provide the first estimates of the typical mechanical response of the ONH to variations in IOP over a large population of ONHs. (Invest Ophthalmol Vis Sci.

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“…8(d)]. This high birefringence originate from the dura mater that is known to extend from the ONH towards the temporal direction in highly myopic eyes [55,56]. scleral in the yellow and red boxes in Fig.…”

Section: Myopic Choroidal Neovascularization With Choroidal Atrophymentioning

confidence: 99%

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Sugiyama

Hong

Kasaragod

et al. 2015

Biomed. Opt. Express

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Abstract:A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1-µm wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines/s, and 6.6 µm in tissue, respectively. Normal and pathologic eyes are examined and several clinical features are revealed, which includes high birefringence in the choroid and lamina cribrosa, and birefringent layered structure of the sclera. The theoretical details of the depth-localized birefringence imaging and conventional phase retardation imaging are formulated. This formulation indicates that the birefringence imaging correctly measures a depth-localized single-trip phase retardation of a tissue, while the conventional phase retardation can provide correct single-trip phase retardation only for some specific types of samples.

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Histology of the Parapapillary Region in High Myopia

Cited by 119 publications

References 28 publications

Parapapillary atrophy: histological gamma zone and delta zone

Parapapillary atrophy: histological gamma zone and delta zone

The Optic Nerve Head as a Robust Biomechanical System

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

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