Histological study of the effect of potassium dichromate on the thyroid follicular cells of adult male albino rat and the possible protective role of ascorbic acid (vitamin C)

Elbakry, Reda H.; Tawfik, Sadika M.

doi:10.1016/j.jmau.2014.04.003

Cited by 17 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The referred cause might be related to increased demand to thyroid hormones which stored in thyroid colloid and the empty thyroid lumenae might be due to more extraction of stored thyroid colloid to meet the hypothyroidism state. The findings of the present study were similar to Rubin and Strayer (2008) [21] and El Bekry and Tawfik (2014) [22] . In toludine blue stained thyroid sections of this group, there were many mast cells in the interstitial tissue mainly around the blood capillaries.…”

Section: Discussionsupporting

confidence: 92%

“…These finding might be due to loss of cell support and hydropic degeneration of the interstitial tissue with the presence of interstitial oedema. Another explanation was reported by El Bekry and Tawfik (2014) [22] who mentioned that collapse of some follicles or necrosis of the other follicles leaving empty spaces lead to widening in the interstitial spaces.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Role of Stem Cells in Management of Experimentally Induced Hypothyroidism in Albino Rat

Abd-El-Aty¹,

Arafa

2019

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Hypothyroidism is a common condition with potentially devastating health consequences that spread worldwide. Stems cells (SCs) based therapy had showed promising benefits in treatment of many diseases on animal models and applied on some human clinical issues. Aim of Study: To investigate the effect of bone marrow mesenchymal stem cells (BM-MSCs) on the biochemical and histological structures of the thyroid gland after experimentally induced hypothyroidism in adult male albino rats. Material and Methods: Forty five adult male Sprague-Dawley albino rats were divided into 3 equal groups: Control group (Group I), Hypothyroidism induced group (Group II); received orally carbimazole 45mg/kg of rat/day for 5 days/week for 4 weeks and Induced hypothyroidism treated with BM-MSCs group (Group III); received oral dose of carbimazole 45mg/kg of rat/day for 5 days/week for 4weeks then received single intravenous injection of 1x10 6 cells of BM-MSCs. This group was subdivided into three equal subgroups according to the time of scarification; Subgroup III6: Scarified at the end of 6th week, Subgroup III8: Scarified at the end of 8 th week and Subgroup III10: Scarified at the end of 10 th week. At the end of the experiment, the hormones of thyroid function were measured and histological examination of the thyroid tissue were done. In addition to morphometric study and statistical analysis. Results: BM-MSCs injection to the induced hypothyroidism rats showed that after 6 and 8 weeks, there were highly significant increase (p<0.01) of freeT3 and T4 values and highly significance decrease of TSH compared to the induced hypothyroidism group. On the other hand, after 10 weeks from injection of BM-MSCs, there were insignificant differences (p>0.05) of free T3, T4 and TSH compared to the induced hypothyroidism group. The histological examination of the induced hypothyroidism after 6 weeks of BM-MSCs injection showed variable degree of response. However, after 8 weeks of BM-MSCs injection, there was universal improve

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%