Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Abstract

Objective To evaluate contralateral testicular blood flow eral testes of the torsion group were collapsed. The diÂerence between the contralateral testes of the two by histological examination of arterioles during ipsilateral testicular torsion.groups and between the ipsilateral and contralateral testes in the torsion group were significant. The diamMaterials and methods The study comprised two groups of 20 male albino rats (weight 250-270 g). The eter of uncollapsed arterioles did not diÂer significantly among either testes of the control and torsion groups control group underwent a sham operation, while in the second group the left testes were twisted clockwise and either testes in each group. Both testes in the torsion group had significantly more arterioles conby 720°. All rats underwent bilateral orchidectomy 24 h after the initial intervention. Three slides for taining blood cells than those in the control group. The diÂerence between the testes in the torsion group each testis (n=240) were evaluated randomly while unaware of treatment to determine the total number was also significant, but was not in the control group. Conclusion There was histological evidence of decreased of arterioles, the percentage of collapsed and open arterioles, the diameter of open arterioles and the blood flow in the contralateral testis during unilateral testicular torsion; contralateral testicular damage presence or absence of blood cells in the lumen. DiÂerences were assessed using t-tests for paired and during unilateral testicular torsion may result from hypoxia caused by decreased blood flow. independent samples. Results Very few arterioles were collapsed in both testes Keywords Spermatic cord torsion, testicular injury, contralateral of the control group and in the ipsilateral testes of the torsion group, but half the arterioles in the contralatepisodes of contralateral testicular torsion and underlying

Rosiglitazone, an Agonist of Peroxisome Proliferator‐activated Receptor‐gamma, Prevents Contralateral Testicular Ischaemia–reperfusion Injury in Prepubertal Rats

“…Several mechanisms, including an immunological phenomenon, release of acrosomal enzymes, blood flow alterations, an underlying congenital testicular defect, presence of underlying defect of spermatogenesis, paired neuroendocrine or vasomotor response during torsion and subclinical attacks of contralateral testicular torsion, are claimed to be responsible on this issue. 2,4,[20][21][22][23][24][25] In the testicular tissue, MTBS is used to assess histopathological damage. It is based on the evaluation of progressive degeneration of the germinal epithelium.…”

The protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsion

“…There have been several recent clinical and experimental studies of contralateral testicular injury after UTT; most of these studies [1±12] reported contralateral testicular damage, with speci®c histological [1,3,9±11] and biochemical [5] changes after UTT, although others disagree [13±17]. Of the several proposed causes for such damage, a re¯ex decrease in contralateral testicular blood¯ow is probably the most likely [2,5, 12,18].…”

The effect of dexketoprofen on ischemia reperfusion injury

“…It has been suggested that ipsilateral testicular torsion may cause oxidative stress and injury in the contralateral testicle. Several mechanisms, such as an increase in biomarkers that cause DNA changes (21), apoptosis (22), free oxygen radical secretion from the testicle (23), refl ex decrease in contralateral testicle blood fl ow (24), and autoimmunization by the destroyed blood-testicle barrier (25), have been described. However, other studies were unable to show injury in the contralateral testicle (26,27).…”