The effect of dexketoprofen on ischemia reperfusion injury

Abstract

Abstract:Objective: The purpose of this study was to demonstrate the effects of dexketoprofen on experimental ischemia/reperfusion injury induced in rat testicles. Methods: Twenty-four male Wistar albino-type rats were randomly separated into three groups. To develop testicular torsion, the right testicle was rotated 720° clockwise. After fi ve hours of rotation, reperfusion was applied for 24 hours. The control group rats (Group C) had no procedures or treatments; basal numbers were used. Intraperitoneal 25 mg/kg dexketoprofen (1 cc) (Group D) or the same volume of serum physiologic (Group SP) were given to the Group D and Group SP rats 40 minutes before and 12 hours after detorsion. Twenty-four hours after detorsion, histopathological evaluation was performed by bilateral orchiectomy. Malondialdehyde (MDA) levels were detected in testicular tissue and in serum. Results: Histopathologic changes in the spermatic cells of torsioned testicles in Group D were signifi cantly less than those of Group SP (p < 0.05). MDA levels in both testicles in Group D were similar to those of the control group. Although they were lower than Group SP, the difference was not statistically signifi cant. Serum MDA levels were lower in Group D compared to the other groups (p < 0.05). Conclusion: We detected that dexketoprofen decreases I/R injury in both the torsion-formed testicle and the contralateral testicle. Thus, in patients who have urgent surgery for testicular detorsion, dexketoprofen can be preferred as an analgesic to reduce I/R injury. Further study is warranted to demonstrate this effect of dexketoprofen (Tab. 3, Fig. 1, Ref. 30). Text in PDF www.elis.sk.

Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

“…When used in a 5‐h testicular ischemia model, it was given twice intraperitoneally, once 40 min before the reperfusion and then 12 h after the reperfusion. In total, 24 h after reperfusion, dexketoprofen significantly decreased lipid peroxidation levels in both testes, and reduced the degeneration, necrosis, disorganization and desquamation observed in the testicular tissue compared with that seen in the control animals …”

“…In total, 24 h after reperfusion, dexketoprofen significantly decreased lipid peroxidation levels in both testes, and reduced the degeneration, necrosis, disorganization and desquamation observed in the testicular tissue compared with that seen in the control animals. 66…”

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

“…Yildirim et al[86] studied the intraperitoneal effect of dexketoprofen in a rat model of I/R injury. Malondialdehyde (MDA) levels were investigated in tissue and serum of torsioned testicles in the dexketoprofen group and control group.…”

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

“…Yazdani et al [ 108 ] revealed that treatment with Cyclosporine A (CsA), a strong agent for closing the mitochondrial permeability transition pore (mPTP), could maintain the antioxidant enzymes, abate oxidative stress-induced cell apoptosis, improve sperm quality, demonstrating CsA as a potential pharmaceutical adjunct for treating and preventing I/R-induced testicular injury in post-conditioning men to enhance fertility. In another investigation, Yildirim et al [ 109 ] investigated the impact of dexketoprofen on ischemia-reperfusion damage. It reduces pathologic alterations in spermatogenic cells and serum MDA levels in testicular torsion, suggesting that it attenuates oxidative stress [ 211 ].…”